Physical Exercise and Heat Shock Proteins

  • Amin IsanejadEmail author
  • Hamid Amini
Part of the Heat Shock Proteins book series (HESP, volume 16)


Molecular chaperones consist of several highly conserved families of proteins, many of which consist of heat shock proteins. Heat shock proteins (HSP) are a group of cytoprotective proteins critical in the maintenance of protein and cellular homeostasis and protect the cell against further insults. HSP also can actively release to circulation and function as chaperokine. It has become suggested that they induced or activated with acute exercise or after chronic exercise training. It seems that a combination of thermal, oxidative and metabolic stress and muscle damage involved in exercise-induced HSP. These chaperones can play important role in biological response and adaptation by exercise. It is well known that the levels of certain molecular chaperones are elevated during stress to provide protection to the cell. For example stress response get disturbed in some conditions such as, cancer, diabetes and Alzheimer’s, furthermore in conditions that may stimulated disease such as aging. In the present chapter we discussed the role of exercise on these classes of chaperones in biology of exercise and human diseases. Exercise training, by improving the level of HSP, can help to amplify the stress response. These observations provided an opportunity to exploit protective role of HSP health and physical performance. Therefore, identifying the biological effects of these chaperons in exercise can lead to a greater understanding of the mechanisms of exercise in medicine and exercise adaptation biology.


Chaperones HSP Muscle adaptation Exercise training ROS Aging 



Androgen deprivation therapy


Immunoglobulin binding protein


Chaperonin containing TCP-1 beta subunit


Creatine kinase


C reactive protein


Endoplasmic reticulum


Extracellular signal-regulated kinase


Forkhead box protein O1


Glucose-regulated protein 75


Glycogen synthase


Glycogen synthase kinases α


Heat shock factor


Heat shock factor1


Heat shock proteins


Inhibitor of NF-kb kinase




Inositol-requiring transmembrane kinase/endonuclease-1


c-Jun NH2-terminal kinase


Nuclear factor kappa-light-chain-enhancer of activated B cells


Nuclear genes encoding mitochondrial proteins


Neuronal protein 22


Phosphoinositide 3-kinase-Akt

p38 MAPK

P38 mitogen-activated protein kinases


Peroxisome proliferator-activated receptor gamma coactivator 1-alpha


Reactive nitrogen species


Reactive oxygen species


Silent mating type information regulation 2 homolog


Superoxide dismutase


Tumor necrosis factor alpha


Toll like receptor


Unfolded protein response



This work was supported by the Shahed University, Tehran, Iran.


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© Springer Nature Switzerland AG 2019

Authors and Affiliations

  1. 1.Immunoregulation Research CenterShahed UniversityTehranIran
  2. 2.Sport Sciences DepartmentShahed UniversityTehranIran
  3. 3.Department of Physical Education and Sports Sciences, Yadegar-e-Imam Khomeini (RAH) Shahre Rey BranchIslamic Azad UniversityTehranIran

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