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Treatment of ANCA-Associated Vasculitides

  • Loïc GuillevinEmail author
  • Loïc Raffray
  • Yann Nguyen
  • Benjamin Chaigne
  • Benjamin Terrier
Chapter
Part of the Rare Diseases of the Immune System book series (RDIS)

Abstract

A subgroup of systemic necrotizing vasculitides, antineutrophil cytoplasm antibody (ANCA)-associated vasculitides (AAVs), are known to have circulating ANCA in >30–90% of the affected patients. Granulomatosis with polyangiitis (GPA, formerly Wegener’s granulomatosis), eosinophilic granulomatosis with polyangiitis (EGPA, formerly Churg–Strauss syndrome), and microscopic polyangiitis (MPA) are AAVs [1]. Renal-limited vasculitis, another AAV, is a bit of a question mark, as it is a disease that initially affects the kidney but could then evolve to become MPA or GPA. All AAVs affect small-sized vessels, and ANCA are thought to play a role in their pathogeneses. Due to our improved understanding of AAV pathophysiological mechanisms and identification of their cellular and molecular targets, AAV treatments are now more specific than they had been in the past.

Keywords

Vasculitis ANCA Corticosteroids Immunosuppressants Plasma exchange Rituximab Mepolizumab 

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Copyright information

© Springer Nature Switzerland AG 2020

Authors and Affiliations

  • Loïc Guillevin
    • 1
    Email author
  • Loïc Raffray
    • 2
  • Yann Nguyen
    • 1
  • Benjamin Chaigne
    • 1
  • Benjamin Terrier
    • 1
  1. 1.Department of Internal Medicine, Referral Center for Rare Systemic and Autoimmune Diseases, Hôpital CochinUniversité Paris DescartesParisFrance
  2. 2.Department of Internal MedicineFélix-Guyon University Hospital of La RéunionSaint Denis, Réunion IslandFrance

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