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Derivatives of 2,5-Diaryl-1,3-Oxazole and 2,5-Diaryl-1,3,4-Oxadiazole as Environment-Sensitive Fluorescent Probes for Studies of Biological Membranes

  • Yevgen O. Posokhov
  • Alexander Kyrychenko
  • Yevgen Korniyenko
Chapter
Part of the Reviews in Fluorescence book series (RFLU)

Abstract

In this review, we present the progress in design and applications of fluorescent membrane probes, based on derivatives of diaryloxazole and diaryloxadiazole. We illustrate the use of the mentioned fluorescent probes for the spectroscopic visualization of pathological changes in human platelet membranes during atherosclerosis and in membranes of intestinal enterocytes of rats in the course of chronic carrageenan-induced gastroenterocolitis. Also, the use of the fluorescent probes for monitoring of the changes in physico-chemical properties of biological membranes under the action of volatile organic solvents, low molecular weight cryoprotectants and weak constant magnetic field is discussed.

Keywords

Fluorescence spectroscopy Fluorescent probe Spectroscopic visualization Atherosclerosis Human platelets Gastroenterocolitis Enterocyte Biological membrane Lipid bilayer 

Notes

Acknowledgments

We are grateful to Prof. A.O. Doroshenko for gifting us with supplies of derivatives of diaryloxazole and diaryloxadiazole; to M.D. I.V. Reminyak for valuable comments and for supplying us with the samples of blood platelets from the patients and from healthy volunteers; to M.D. A.S. Tkachenko for valuable comments and for supplying us with the samples of intestinal enterocytes of rats; and also to Dr. D.A. Bevziuk for supplying us with the samples of the cells of olfactory analyzer of rats and for valuable comments.

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Copyright information

© Springer Nature Switzerland AG 2018

Authors and Affiliations

  • Yevgen O. Posokhov
    • 1
  • Alexander Kyrychenko
    • 2
  • Yevgen Korniyenko
    • 3
  1. 1.Department of Organic Chemistry, Biochemistry and MicrobiologyThe National Technical University “Kharkiv Polytechnic Institute”KharkivUkraine
  2. 2.Institute of Chemistry and School of ChemistryV. N. Karazin Kharkiv National UniversityKharkivUkraine
  3. 3.Department of Human and Animal PhysiologyV. N. Karazin Kharkiv National UniversityKharkivUkraine

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