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Hydroporphyrins in Fluorescence In Vivo Imaging

  • Marcin PtaszekEmail author
Chapter
Part of the Reviews in Fluorescence book series (RFLU)

Abstract

Over the last several years significant progress has been made on the development of near infrared (near-IR) organic, inorganic, and nanomaterial fluorophores for diagnostic and therapeutic applications (Ptaszek M, Prog Mol Biol Transl Sci 113:59–108, 2013; Chernov KG, Redchuk TA, Omelina ES, Verkusha VV, Chem Rev 117:6423–6446, 2017; Chen G, Qiu H, Prasad PN, Chen X, Chem Rev 114:5161–5214, 2014; Dong H, Du S-R, Zheng X-Y, Lyu G-M, Sun L-D, Li L-D, Zhang P-Z, Zhang C, Yan C-H, Chem Rev 115:10725–10815, 2015; Smith BR, Gambhir SS, Chem Rev 117:901–986, 2017; Xu G, Zeng S, Zzhang B, Swihart MT, Yong K-T, Prasad P, Chem Rev 117:901–986, 2017; Zhou J, Yang Y, Zhang C-y, Chem Rev 115:11669–11717, 2015; Hong G, Diao S, Antaris AL, Dai H, Chem Rev 117:6423–6446, 2017) .Among them, hydroporphyrins have emerged as a class of photonic agents, with a set of unique properties, which may expand the frontiers of fluorescence medicinal imaging. This article discusses basic optical and photochemical properties of hydroporphyrins, reviews their applications as contrast agents for in vivo fluorescence imaging, and highlights recent advances in the development of hydroporphyrin energy transfer arrays with potential applications in fluorescence imaging.

Keywords

Near-IR fluorophores Chlorins Bacteriochlorins Fluorescence bioimaging Multicolor fluorescence imaging 

Notes

Acknowledgment

Author thanks National Cancer Institute of the National Institutes of Health (award U01CA181628) for supporting his work on near-IR fluorophores for in vivo imaging, and Mr. Adam Meares for valuable discussion.

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Authors and Affiliations

  1. 1.Department of Chemistry and BiochemistryUniversity of Maryland, Baltimore CountyBaltimoreUSA

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