fMRI and Tractographic Studies of Cognitive Systems in the Human Brain at the Norm and the Paranoid Schizophrenia
This study is aimed at a systematic study of the work of neural networks of the human brain and their architecture in norm and in schizophrenia. To obtain the neurophysiological data, a unique complex of experimental equipment for world-class neurocognitive studies was used. The data obtained showed a significant decrease in the structural connectivity relationships for the rich club coefficient for a group of schizophrenic patients compared with the norm. Perception of emotionally negative visual and audio stimuli related to delusions in patients with schizophrenia does not lead to a significant decrease in BOLD signal as compared with the norm in Calcarine_L, Cerebelum_4_5_R, ParaHippocampal_LR, Precuneus_L, Temporal_Sup_R areas. The differences found in the structural and functional patterns of cognitive-affective disorders can serve as prognostic biomarkers in patients with schizophrenia and will make a significant contribution to the development of high-tech diagnostics in the early stages of mental illness.
KeywordsfMRI Rich-club Cognitive architecture Connectome Schizophrenia Hallucinatory-paranoid syndrome
This study was partially supported by RFBR Grant ofi-m 17-29-02518 (the cognitive-effective structures of the human brain) and by the NRC “Kurchatov Institute” (11.07.2018 № 1649, MR compatible polygraphy). The authors are grateful to the MEPhI Academic Excellence Project for providing computing resources and facilities to perform experimental data processing.
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