Cell Therapy Using Cultivated Oral Mucosal Epithelial Transplant (COMET)

  • Roberto Fernández Buenaga
  • Sajjad Ahmad
Part of the Essentials in Ophthalmology book series (ESSENTIALS)


A significant proportion of patients with limbal stem cell failure (LSCF) have bilateral disease. In these cases, there is most often no area of healthy limbus in either eye to use a source of donor limbal stem cells. Therefore, limbal allograft procedures (either allogeneic whole limbal tissue grafting, allo-CLET, or allo-SLET) become the only valid treatment options. However, these procedures are accompanied by the risk of rejection and the requirement of potent systemic immune suppression. The rationale of COMET is to overcome these drawbacks by means of using autologous mucosal epithelium of non-ocular surface origin.


Limbal failure COMET Chemical burn Cicatrising conjunctivitis 


Compliance with Ethical Requirements

Sajjad Ahmad and Roberto Fernandez Buenaga declare that they have no conflict of interest. No human or animal studies were carried out by the authors for this chapter.


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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Roberto Fernández Buenaga
    • 1
  • Sajjad Ahmad
    • 2
  1. 1.Cornea, Cataract and Refractive Surgery DepartmentVissum MadridMadridSpain
  2. 2.Cornea and External Diseases DepartmentMoorfields Eye HospitalLondonUK

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