Simple Limbal Epithelial Transplantation: An Update
Limbal stem cell deficiency (LSCD) is a condition characterized by the delay or failure of normal corneal epithelialization. This aberrant process can lead to conjunctivalization, superficial corneal neovascularization, and ultimately poor healing of the corneal surface, resulting in corneal blindness. The treatment of LSCD can be complex and can range from conservative approaches to surgical interventions. Recently, simple limbal epithelial transplantation (SLET) has emerged as a novel surgical technique for the treatment of unilateral LSCD with promising results. In this chapter, we review the SLET surgical technique and discuss the advantages and drawbacks of this surgical modality.
KeywordsLimbal stem cell deficiency Simple limbal epithelial transplantation
We would like to thank Dr. Anat Galor MD MSPH for assistance in obtaining clinical photographs used in this publication.
Compliance with Ethical Requirements
Conflict of InterestNandini Venkateswaran and Guillermo Amescua declare that they have no conflict of interest.
Informed ConsentNo human studies were carried out by the authors for this article.
No animal studies were carried out by the authors for this article.
- 2.Atallah MR, Palioura S, Perez VL, Amescua G. Limbal stem cell transplantation: current perspectives. Clinical Ophthalmol (Auckland, NZ). 2016;10:593–602.Google Scholar
- 11.Arora R, Dokania P, Manudhane A, Goyal JL. Preliminary results from the comparison of simple limbal epithelial transplantation with conjunctival limbal autologous transplantation in severe unilateral chronic ocular burns. Indian J Ophthalmol. 2017;65(1):35–40.PubMedPubMedCentralCrossRefGoogle Scholar
- 23.Bhalekar S, Basu S, Lal I, Sangwan VS. Successful autologous simple limbal epithelial transplantation (SLET) in previously failed paediatric limbal transplantation for ocular surface burns. BMJ Case Reports. 2013;2013:bcr2013009888. https://doi.org/10.1136/bcr-2013-009888.PubMedPubMedCentralCrossRefGoogle Scholar
- 24.Nair D, Mohamed A, Sangwan VS. Outcome of cataract surgery following simple limbal epithelial transplantation for lime injury-induced limbal stem cell deficiency. BMJ Case Rep. 2015;2015.Google Scholar