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The Robustness/Sensitivity Paradox: An Essay on the Importance of Phase Separation

  • Alessandro GiulianiEmail author
Chapter
Part of the History, Philosophy and Theory of the Life Sciences book series (HPTL, volume 23)

Abstract

Considering biological systems at different levels of organization as complex networks in which nodes (genes, proteins, metabolites…) are each other connected by (co-expression, physical interactions) is a very natural way of reasoning. Network approach allows scientist to make sense of the intricacies of biological regulation and, for the same mathematical nature of graphs, to obtain a multilevel description linking single node and whole network topological features. This paradigm allows for the detection of a clear signature of robustness: the ability of a system to keep separate different scales of response to environmental stimuli. A case study on the immune system allows for an immediate appreciation of this point.

Keywords

Self-organization Gene expression regulation Networks Systems biology Innate immunity 

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Copyright information

© Springer Nature Switzerland AG 2018

Authors and Affiliations

  1. 1.Environment and Health DepartmentIstituto Superiore di SanitàRomeItaly

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