Secondary Metabolites of Endophytic Actinomycetes: Isolation, Synthesis, Biosynthesis, and Biological Activities

  • Darlon Irineu Bernardi
  • Fernanda Oliveira das Chagas
  • Afif Felix Monteiro
  • Gabriel Franco dos Santos
  • Roberto Gomes de Souza BerlinckEmail author
Part of the Progress in the Chemistry of Organic Natural Products book series (POGRCHEM, volume 108)


Endophytic Actinobacteria are a microbial group that is still poorly investigated. Their association with plants constitutes a unique trait conferring specific biological and chemical features to endophytic Actinobacteria. This contribution discusses aspects of endophytic actinobacterial biology and chemistry comprehensively, including the biosynthesis and total synthesis of secondary metabolites produced in culture. It also presents perspectives for the future of microbial bioactive natural products discovery, with emphasis on the secondary metabolism of endophytic Actinobacteria.


Endophytic actinobacteria Biosynthesis Polyketide total synthesis Alkaloid total synthesis 



The authors thank Professor Heinz Falk (Johannes Kepler Universität Linz) for many suggestions that improved the manuscript. Financial support was provided by Fundação de Amparo à Pesquisa do Estado de São Paulo to RGSB (2013/50228-8), as well as a Ph.D. scholarship awarded to DIB (2016/21341-9). The Brazilian funding agency Conselho Nacional de Desenvolvimento Científico e Tecnológico is also gratefully acknowledged for postdoctoral fellowships awarded to AFM and GFS.


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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Darlon Irineu Bernardi
    • 1
  • Fernanda Oliveira das Chagas
    • 2
  • Afif Felix Monteiro
    • 1
  • Gabriel Franco dos Santos
    • 1
  • Roberto Gomes de Souza Berlinck
    • 1
    Email author
  1. 1.Instituto de Química de São CarlosUniversidade de São PauloSão CarlosBrazil
  2. 2.Instituto de Pesquisa de Produtos Naturais Walter MorsUniversidade Federal do Rio de JaneiroRio de JaneiroBrazil

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