Computational Glioscience pp 471-505 | Cite as

# Modeling Neuron–Glia Interactions with the *Brian 2* Simulator

## Abstract

In spite of compelling evidence that glial cells could crucially regulate neural network activity, the vast majority of available neural simulators ignores the possible contribution of glia to neuronal physiology. Here, we show how to model glial physiology and neuron–glia interactions in the *Brian 2* simulator. *Brian 2* offers facilities to explicitly describe any model in mathematical terms with limited and simple simulator-specific syntax, automatically generating high-performance code from the user-provided descriptions. The flexibility of this approach allows us to model not only networks of neurons, but also individual glial cells, chemical coupling of glial cells, and the interaction between glial cells and synapses. We therefore conclude that *Brian 2* provides an ideal platform to efficiently simulate glial physiology, and specifically, the influence of astrocytes on neural activity.

## Keywords

*Brian 2*simulator Neuron–glial interactions Tripartite synapses Neuron–glial networks Astrocyte Gliotransmission

## Notes

### Acknowledgements

This work was supported by Agence Nationale de la Recherche (Axode ANR-14-CE13-0003). MDP acknowledges the support of the Junior Leader Fellowship Program by “la Caixa” Banking Foundation, as well as the support by the Basque Government through the BERC 2018-2021 program and by the Spanish Ministry of Science, Innovation and Universities: BCAM Severo Ochoa accreditation SEV-2017-0718. Writing of this chapter was also partly supported by a Marie Skłodowska-Curie International Outgoing Fellowship to MDP from the European Commission (Project 331486 “Neuron-Astro-Nets”).

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