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Astrocytic Ion Dynamics: Implications for Potassium Buffering and Liquid Flow

  • Geir HalnesEmail author
  • Klas H. Pettersen
  • Leiv Øyehaug
  • Marie E. Rognes
  • Gaute T. Einevoll
Chapter
Part of the Springer Series in Computational Neuroscience book series (NEUROSCI)

Abstract

We review modelling of astrocyte ion dynamics with a specific focus on the implications of so-called spatial potassium buffering where excess potassium in the extracellular space (ECS) is transported away to prevent pathological neural spiking. The recently introduced Kirchhoff–Nernst–Planck (KNP) scheme for modelling ion dynamics in astrocytes (and brain tissue in general) is outlined and used to study such spatial buffering. We next describe how the ion dynamics of astrocytes may regulate microscopic liquid flow by osmotic effects and how such microscopic flow can be linked to whole-brain macroscopic flow. We thus describe key elements in a putative multiscale theory with astrocytes linking neural activity on a microscopic scale to macroscopic fluid flow.

Keywords

Tissue modelling Ion concentration dynamics Electrodiffusion Neuron–glia interactions Potassium buffering 

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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Geir Halnes
    • 1
    Email author
  • Klas H. Pettersen
    • 2
  • Leiv Øyehaug
    • 3
  • Marie E. Rognes
    • 4
    • 5
  • Gaute T. Einevoll
    • 1
    • 6
  1. 1.Faculty of Science and TechnologyNorwegian University of Life SciencesÅsNorway
  2. 2.Letten Centre and GliaLab, Centre for Molecular MedicineUniversity of OsloOsloNorway
  3. 3.Faculty of Technology, Art and DesignOsloMet - Oslo Metropolitan UniversityOsloNorway
  4. 4.Simula Research LaboratoryFornebuNorway
  5. 5.Department of MathematicsUniversity of OsloOsloNorway
  6. 6.Department of PhysicsUniversity of OsloOsloNorway

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