Computational Models of Pathophysiological Glial Activation in CNS Disorders
Glial cells, in general, and astrocytes, in particular, are indispensable for homeostatic regulation of neural function, which positions these non-neuronal cells in the limelight of CNS pathologies. The renewed interest in glial physiology and the advent of new experimental methods motivated the development of computational models of glial cells. In this contribution, we review the development and challenges of computational models of pathophysiological glial activation in CNS disorders.
KeywordsBrain injury Homeostatic plasticity Computational neurology Quantitative systems pharmacology Neuroinflammation
MB acknowledges financial support through the research grants from the Office of Naval Research (MURI, N000141310672) and National Institutes of Health (R01 EB009282 and R01 MH099645). The work of VV was sponsored by the US Army Medical Research and Materiel Command under contract W81XWH-11-D-0011. This document is cleared for all audiences for OPSEC purposes. Cleared for public release 09/25/2015. The opinions or assertions contained herein are private views of the authors and are not to be construed as official or as reflecting views of the Department of the Army or the Department of Defense. PAO reviewed.
- Ng LJ, Gibbons M, Phohomsiri P, Volman V, Cui J et al (2014) Investigation of the concussion mechanism: an end-to-end model that translates external measures to internal neurologic injury, Tampa, FLGoogle Scholar
- Øyehaug L, Østby I, Lloyd CM, Omholt SW, Einevoll GT (2011) Dependence of spontaneous neuronal firing and depolarization block on astroglial membrane transport mechanisms. J Comput NeurosciGoogle Scholar
- Timofeev I, Bazhenov M, Seigneur J, Sejnowski TJ (2012) Neuronal synchronization and thalamocortical rhythms in sleep, wake, and epilepsy. In: Noebels JLAM, Rogawski MA, Olsen RW, Delgado-Escueta AV (eds) Jasper’s basic mechanisms of the epilepsies. Oxford University Press, New York, pp 157–175CrossRefGoogle Scholar