Tumour Therapy-Induced Osteoporosis
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Many treatment protocols in oncology lead to manifest osteoporosis. Irradiation causes local atrophy of the bone and bone marrow due to the toxic effects on the bone and bone marrow cells, while chemotherapy and hormone therapy induce systemic rarefaction of both trabecular and cortical bones. Moreover, these iatrogenic effects may even be increased by a direct effect on the bone of the tumour itself, which could well have preceded the deleterious effects of the therapy.