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Tumour Therapy-Induced Osteoporosis

  • Reiner Bartl
  • Christoph Bartl
Chapter

Abstract

Many treatment protocols in oncology lead to manifest osteoporosis. Irradiation causes local atrophy of the bone and bone marrow due to the toxic effects on the bone and bone marrow cells, while chemotherapy and hormone therapy induce systemic rarefaction of both trabecular and cortical bones. Moreover, these iatrogenic effects may even be increased by a direct effect on the bone of the tumour itself, which could well have preceded the deleterious effects of the therapy.

Keywords

Bone loss Aromatase inhibitor Malignant lymphoma Acute lymphatic leukaemia Steroidal aromatase inhibitor 

Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Reiner Bartl
    • 1
  • Christoph Bartl
    • 1
    • 2
  1. 1.Osteoporosis and Bone CenterMunichGermany
  2. 2.Center of Orthopaedics and Sports MedicineMunichGermany

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