Towards Subject and Diagnostic Identifiability in the Alzheimer’s Disease Spectrum Based on Functional Connectomes

  • Diana O. Svaldi
  • Joaquín Goñi
  • Apoorva Bharthur Sanjay
  • Enrico Amico
  • Shannon L. Risacher
  • John D. West
  • Mario Dzemidzic
  • Andrew Saykin
  • Liana Apostolova
Conference paper
Part of the Lecture Notes in Computer Science book series (LNCS, volume 11044)


Alzheimer’s disease (AD) is the only major cause of mortality in the world without an effective disease modifying treatment. Evidence supporting the so called “disconnection hypothesis” suggests that functional connectivity biomarkers may have clinical potential for early detection of AD. However, known issues with low test-retest reliability and signal to noise in functional connectivity may prevent accuracy and subsequent predictive capacity. We validate the utility of a novel principal component based diagnostic identifiability framework to increase separation in functional connectivity across the Alzheimer’s spectrum by identifying and reconstructing FC using only AD sensitive components or connectivity modes. We show that this framework (1) increases test-retest correspondence and (2) allows for better separation, in functional connectivity, of diagnostic groups both at the whole brain and individual resting state network level. Finally, we evaluate a posteriori the association between connectivity mode weights with longitudinal neurocognitive outcomes.


Alzheimer’s disease Functional connectivity Principal component analysis Resting state fMRI 


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Copyright information

© Springer Nature Switzerland AG 2018

Authors and Affiliations

  1. 1.Indiana University School of MedicineIndianapolisUSA
  2. 2.Purdue UniversityLafayetteUSA

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