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NMR Identification of Biologically Active Natural Products: Strategies and Challenges

  • Gloria Ivonne Hernández-Bolio
  • Luis Manuel Peña-Rodríguez
Chapter

Abstract

Nuclear magnetic resonance has evolved into a spectroscopic technique that makes the identification of a natural product possible in a relatively short period of time. Currently, the advances in instrumentation and in pulse sequence development produce better spectra and experiments that provide a great deal of information about the chemical structure of a given product. Still, the skills of the researcher are critical for extraction and interpretation of the data, when facing the challenge of putting the molecular puzzle together. These skills can be acquired by having a good knowledge of both the technique and its experimentation possibilities, which provide the experience necessary to recognize the NMR features of different classes of molecules. We present here a number of strategies and challenges used in our laboratory for the identification of different natural products obtained during our search for bioactive metabolites from the native flora of the Yucatán Peninsula.

Keywords

Nuclear magnetic resonance Natural products Structure elucidation 1H-NMR 13C-NMR 

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Copyright information

© Springer Nature Switzerland AG 2018

Authors and Affiliations

  • Gloria Ivonne Hernández-Bolio
    • 1
  • Luis Manuel Peña-Rodríguez
    • 1
  1. 1.Unidad de Biotecnología, Centro de Investigación Científica de YucatánMéridaMéxico

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