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Targeted Therapeutics for Lymphoma: Using Biology to Inform Treatment

  • T. E. C. Cummin
  • M. S. Cragg
  • J. W. FriedbergEmail author
  • P. W. M. Johnson
Chapter
Part of the Hematologic Malignancies book series (HEMATOLOGIC)

Abstract

A significant proportion of patients with B- and T-cell aggressive non-Hodgkin lymphomas are not cured by standard of care immunochemotherapy, and recent randomised studies have failed to improve outcomes for patients with the most common type, diffuse large B-cell lymphoma. Advances in molecular biology have confirmed aggressive lymphomas to be molecularly heterogeneous, but at present biological knowledge provides limited guidance for clinical practice. This is likely to change as discovery science and targeted therapies in clinical trials begin to identify subtypes that may respond differentially to specific treatments. This chapter reviews the evidence to date and the prospects for changes to clinical practice in the future.

Keywords

Lymphoma Precision medicine Next-generation sequencing Gene expression profiling Circulating tumour DNA Small molecule inhibitors 

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Authors and Affiliations

  • T. E. C. Cummin
    • 1
  • M. S. Cragg
    • 2
  • J. W. Friedberg
    • 3
    Email author
  • P. W. M. Johnson
    • 1
  1. 1.Cancer Research UK CentreUniversity of SouthamptonSouthamptonUK
  2. 2.Antibody and Vaccine Group, Cancer Sciences Unit, Faculty of MedicineUniversity of SouthamptonSouthamptonUK
  3. 3.Department of Medicine, Wilmot Cancer InstituteUniversity of Rochester Medical CenterRochesterUSA

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