Biomedical X-Ray Phase-Contrast Imaging and Tomography

Part of the Springer Handbooks book series (SHB)


This chapter reviews the main categories of methods that have been developed for preclinical and clinical imaging applications. The methods covered here are all based on geometric magnification by the projection of a cone beam emitted from a pseudopoint source, without the use of a lens or other types of focusing optics. These methods share the common goal of detecting x-ray refraction and diffraction, in order to complement the conventional attenuation contrast information in radiography and computed tomography.


  1. C.T. Chantler, K. Olsen, R.A. Dragoset, J. Chang, A.R. Kishore, S.A. Kotochigova, D.S. Zucker: X-Ray Form Factor, Attenuation and Scattering Tables, Version 2.1 (NIST, Gaithersburg 2005)Google Scholar
  2. A. Snigirev, I. Snigireva, V. Kohn, S. Kuznetsov, I. Schelokov: On the possibilities of x-ray phase contrast microimaging by coherent high-energy synchrotron radiation, Rev. Sci. Instrum. 66(12), 5486–5492 (1995)Google Scholar
  3. S.W. Wilkins, T.E. Gureyev, D. Gao, A. Pogany, A.W. Stevenson: Phase-contrast imaging using polychromatic hard x-rays, Nature 384(6607), 335–338 (1996)Google Scholar
  4. S.C. Mayo, P.R. Miller, S.W. Wilkins, T.J. Davis, D. Gao, T.E. Gureyev, D. Paganin, D.J. Parry, A. Pogany, A.W. Stevenson: Quantitative x-ray projection microscopy: Phase-contrast and multi-spectral imaging, J. Microsc. 207, 79–96 (2002)Google Scholar
  5. S.C. Mayo, T.J. Davis, T.E. Gureyev, P.R. Miller, D. Paganin, A. Pogany, A.W. Stevenson, S.W. Wilkins: X-ray phase-contrast microscopy and microtomography, Opt. Express 11(19), 2289–2302 (2003)Google Scholar
  6. J. Dudak, J. Zemlicka, J. Karch, M. Patzelt, J. Mrzilkova, P. Zach, Z. Hermanova, J. Kvacek, F. Krejci: High-contrast x-ray micro-radiography and micro-CT of ex-vivo soft tissue murine organs utilizing ethanol fixation and large area photon-counting detector, Sci. Rep. 6, 30385 (2016)Google Scholar
  7. O. Hemberg, M. Otendal, H.M. Hertz: Liquid-metal-jet anode electron-impact x-ray source, Appl. Phys. Lett. 83(7), 1483–1485 (2003)Google Scholar
  8. D.H. Larsson, U. Lundstrom, U.K. Westermark, M.A. Henriksson, A. Burvall, H.M. Hertz: First application of liquid-metal-jet sources for small-animal imaging: High-resolution CT and phase-contrast tumor demarcation, Med. Phys. 40(2), 021909 (2013)Google Scholar
  9. W. Vagberg, D.H. Larsson, M. Li, A. Arner, H.M. Hertz: X-ray phase-contrast tomography for high-spatial-resolution zebrafish muscle imaging, Sci. Rep. 5, 16625 (2015)Google Scholar
  10. A. Burvall, U. Lundstrom, P.A.C. Takman, D.H. Larsson, H.M. Hertz: Phase retrieval in x-ray phase-contrast imaging suitable for tomography, Opt. Express 19(11), 10359–10376 (2011)Google Scholar
  11. M.A. Beltran, D.M. Paganin, K.K.W. Siu, A. Fouras, S.B. Hooper, D.H. Reser, M.J. Kitchen: Interface-specific x-ray phase retrieval tomography of complex biological organs, Phys. Med. Biol. 56(23), 7353–7369 (2011)Google Scholar
  12. D. Gursoy, M. Das: Single-step absorption and phase retrieval with polychromatic x-rays using a spectral detector, Opt. Lett. 38(9), 1461–1463 (2013)Google Scholar
  13. R.A. Lewis, N. Yagi, M.J. Kitchen, M.J. Morgan, D. Paganin, K.K.W. Siu, K. Pavlov, I. Williams, K. Uesugi, M.J. Wallace, C.J. Hall, J. Whitley, S.B. Hooper: Dynamic imaging of the lungs using x-ray phase contrast, Phys. Med. Biol. 50(21), 5031–5040 (2005)Google Scholar
  14. A.B. Garson, E.W. Izaguirre, S.G. Price, M.A. Anastasio: Characterization of speckle in lung images acquired with a benchtop in-line x-ray phase-contrast system, Phys. Med. Biol. 58(12), 4237–4253 (2013)Google Scholar
  15. R.P. Murrie, K.S. Morgan, A. Maksimenko, A. Fouras, D.M. Paganin, C. Hall, K.K.W. Siu, D.W. Parsons, M. Donnelley: Live small-animal x-ray lung velocimetry and lung micro-tomography at the Australian synchrotron imaging and medical beamline, J. Synchrotron Radiat. 22, 1049–1055 (2015)Google Scholar
  16. M.J. Kitchen, G.A. Buckley, A.F.T. Leong, R.P. Carnibella, A. Fouras, M.J. Wallace, S.B. Hooper: X-ray specks: Low dose in vivo imaging of lung structure and function, Phys. Med. Biol. 60(18), 7259–7276 (2015)Google Scholar
  17. E.H. Kim, M. Preissner, R.P. Carnibella, C.R. Samarage, E. Bennett, M.A. Diniz, A. Fouras, G.R. Zosky, H.D. Jones: Novel analysis of 4-DCT imaging quantifies progressive increases in anatomic dead space during mechanical ventilation in mice, J. Appl. Physiol. 123(3), 578–584 (2017)Google Scholar
  18. C.M. Laperle, T.J. Hamilton, P. Wintermeyer, E. JWalker, D.X. Shi, M.A. Anastasio, Z. Derdak, J.R. Wands, G. Diebold, C. Rose-Petruck: Low density contrast agents for x-ray phase contrast imaging: The use of ambient air for x-ray angiography of excised murine liver tissue, Phys. Med. Biol. 53(23), 6911–6923 (2008)Google Scholar
  19. H. Wen, E.E. Bennett, M.M. Hegedus, S.C. Carroll: Spatial harmonic imaging of x-ray scattering–Initial results, IEEE Trans. Med. Imaging 27(8), 997–1002 (2008)Google Scholar
  20. H. Wen, E.E. Bennett, M.M. Hegedus, S. Rapacchi: Fourier x-ray scattering radiography yields bone structural information, Radiology 251(3), 910–918 (2009)Google Scholar
  21. K.S. Morgan, D.M. Paganin, K.K.W. Siu: Quantitative x-ray phase-contrast imaging using a single grating of comparable pitch to sample feature size, Opt. Lett. 36(1), 55–57 (2011)Google Scholar
  22. K.S. Morgan, D.M. Paganin, K.K.W. Siu: Quantitative single-exposure x-ray phase contrast imaging using a single attenuation grid, Opt. Express 19(20), 19781–19789 (2011)Google Scholar
  23. J. Hartmann: Bemerkungen über den Bau und die Justierung von Spektrographen, Z. Instrumentenkd. 20, 47–58 (1900)Google Scholar
  24. Z.F. Huang, K.J. Kang, L. Zhang, Z.Q. Chen, F. Ding, Z.T. Wang, Q.G. Fang: Alternative method for differential phase-contrast imaging with weakly coherent hard x-rays, Phys. Rev. A 79(1), 013815 (2009)Google Scholar
  25. H.H. Wen, E.E. Bennett, R. Kopace, A.F. Stein, V. Pai: Single-shot x-ray differential phase-contrast and diffraction imaging using two-dimensional transmission gratings, Opt. Lett. 35(12), 1932–1934 (2010)Google Scholar
  26. K.S. Morgan, T.C. Petersen, M. Donnelley, N. Farrow, D.W. Parsons, D.M. Paganin: Capturing and visualizing transient x-ray wavefront topological features by single-grid phase imaging, Opt. Express 24(21), 24435–24450 (2016)Google Scholar
  27. W. Yashiro, Y. Terui, K. Kawabata, A. Momose: On the origin of visibility contrast in x-ray Talbot interferometry, Opt. Express 18(16), 16890–16901 (2010)Google Scholar
  28. S.K. Lynch, V. Pai, J. Auxier, A.F. Stein, E.E. Bennett, C.K. Kemble, X.H. Xiao, W.K. Lee, N.Y. Morgan, H.H. Wen: Interpretation of dark-field contrast and particle-size selectivity in grating interferometers, Appl. Opt. 50(22), 4310–4319 (2011)Google Scholar
  29. A.F. Stein, J. Ilavsky, R. Kopace, E.E. Bennett, H. Wen: Selective imaging of nano-particle contrast agents by a single-shot x-ray diffraction technique, Opt. Express 18(12), 13271–13278 (2010)Google Scholar
  30. J.H. Bruning, D.R. Herriott, J.E. Gallagher, D.P. Rosenfeld, A.D. White, D.J. Brangaccio: Digital wavefront measuring interferometer for testing optical surfaces and lenses, Appl. Opt. 13(11), 2693–2703 (1974)Google Scholar
  31. K.J. Harmon, E.E. Bennett, A.A. Gomella, H. Wen: Efficient decoding of 2-D structured illumination with linear phase stepping in x-ray phase contrast and dark-field imaging, PloS One 9(1), e87127 (2014)Google Scholar
  32. A. Olivo, C.D. Arvanitis, S.E. Bohndiek, A.T. Clark, M. Prydderch, R. Turchetta, R.D. Speller: First evidence of phase-contrast imaging with laboratory sources and active pixel sensors, Nucl. Instrum. Methods Phys. Res. A 581(3), 776–782 (2007)Google Scholar
  33. P.R.T. Munro, K. Ignatyev, R.D. Speller, A. Olivo: Phase and absorption retrieval using incoherent x-ray sources, Proc. Natl. Acad. Sci. U.S.A. 109(35), 13922–13927 (2012)Google Scholar
  34. P.C. Diemoz, M. Endrizzi, C.E. Zapata, Z.D. Pešić, C. Rau, A. Bravin, I.K. Robinson, A. Olivo: X-ray phase-contrast imaging with nanoradian angular resolution, Phys. Rev. Lett. 110(13), 138105 (2013)Google Scholar
  35. H.F. Talbot: LXXVI. Facts relating to optical science, No. IV, Philos. Mag. 9(55), 401–407 (1836)Google Scholar
  36. K.S. Morgan, P. Modregger, S.C. Irvine, S. Rutishauser, V.A. Guzenko, M. Stampanoni, C. David: A sensitive x-ray phase contrast technique for rapid imaging using a single phase grid analyzer, Opt. Lett. 38(22), 4605–4608 (2013)Google Scholar
  37. K.S. Morgan, D.M. Paganin, K.K. Siu: X-ray phase imaging with a paper analyzer, Appl. Phys. Lett. 100(12), 124102 (2012)Google Scholar
  38. S. Berujon, H.C. Wang, I. Pape, K. Sawhney: X-ray phase microscopy using the speckle tracking technique, Appl. Phys. Lett. 102(15), 154105 (2013)Google Scholar
  39. H.C. Wang, Y. Kashyap, K. Sawhney: Speckle based x-ray wavefront sensing with nanoradian angular sensitivity, Opt. Express 23(18), 23310–23317 (2015)Google Scholar
  40. T.H. Zhou, I. Zanette, M.C. Zdora, U. Lundstrom, D.H. Larsson, H.M. Hertz, F. Pfeiffer, A. Burvall: Speckle-based x-ray phase-contrast imaging with a laboratory source and the scanning technique, Opt. Lett. 40(12), 2822–2825 (2015)Google Scholar
  41. E.E. Bennett, R. Kopace, A.F. Stein, H. Wen: A grating-based single-shot x-ray phase contrast and diffraction method for in vivo imaging, Med. Phys. 37(11), 6047–6054 (2010)Google Scholar
  42. D. Rand, V. Ortiz, Y. Liu, Z. Derdak, J.R. Wands, M. Taticek, C. Rose-Petruck: Nanomaterials for x-ray imaging: Gold nanoparticle enhancement of x-ray scatter imaging of hepatocellular carcinoma, Nano Lett. 11(7), 2678–2683 (2011)Google Scholar
  43. D. Rand, M. Uchida, T. Douglas, C. Rose-Petruck: X-ray spatial frequency heterodyne imaging of protein-based nanobubble contrast agents, Opt. Express 22(19), 23290–23298 (2014)Google Scholar
  44. D. Rand, E.G. Walsh, Z. Derdak, J.R. Wands, C. Rose-Petruck: A highly sensitive x-ray imaging modality for hepatocellular carcinoma detection in vitro, Phys. Med. Biol. 60(2), 769–784 (2015)Google Scholar
  45. D. Rand, Z. Derdak, R. Carlson, J.R. Wands, C. Rose-Petruck: X-ray scatter imaging of hepatocellular carcinoma in a mouse model using nanoparticle contrast agents, Sci. Rep. 5, 15673 (2015)Google Scholar
  46. J.F. Clauser, M.W. Reinsch: New theoretical and experimental results in Fresnel optics with applications to matter-wave and x-ray interferometry, Appl. Phys. B 54(5), 380–395 (1992)Google Scholar
  47. P. Cloetens, J.P. Guigay, C. DeMartino, J. Baruchel, M. Schlenker: Fractional Talbot imaging of phase gratings with hard x-rays, Opt. Lett. 22(14), 1059–1061 (1997)Google Scholar
  48. J.F. Clauser: Ultrahigh resolution interferometric x-ray imaging, US Patent 5812629 (1998)Google Scholar
  49. A. Momose, S. Kawamoto, I. Koyama, Y. Hamaishi, K. Takai, Y. Suzuki: Demonstration of x-ray Talbot interferometry, Jpn. J. Appl. Phys. 42(7B), L866–L868 (2003)Google Scholar
  50. T. Weitkamp, A. Diaz, C. David, F. Pfeiffer, M. Stampanoni, P. Cloetens, E. Ziegler: X-ray phase imaging with a grating interferometer, Opt. Express 13(16), 6296–6304 (2005)Google Scholar
  51. F. Pfeiffer, T. Weitkamp, O. Bunk, C. David: Phase retrieval and differential phase-contrast imaging with low-brilliance x-ray sources, Nat. Phys. 2(4), 258–261 (2006)Google Scholar
  52. J. Ming, C.L. Wyatt, G. Wang: X-ray phase-contrast imaging with three 2-D gratings, J. Biomed. Imaging 2008, 827152 (2008)Google Scholar
  53. I. Zanette, T. Weitkamp, T. Donath, S. Rutishauser, C. David: Two-dimensional x-ray grating interferometer, Phys. Rev. Lett. 105(24), 248102 (2010)Google Scholar
  54. S. Marathe, X.B. Shi, M.J. Wojcik, N.G. Kujala, R. Divan, D.C. Mancini, A.T. Macrander, L. Assoufid: Probing transverse coherence of x-ray beam with 2-D phase grating interferometer, Opt. Express 22(12), 14041–14053 (2014)Google Scholar
  55. P. Modregger, S. Rutishauser, J. Meiser, C. David, M. Stampanoni: Two-dimensional ultra-small angle x-ray scattering with grating interferometry, Appl. Phys. Lett. 105(2), 024102 (2014)Google Scholar
  56. A. Momose, W. Yashiro, H. Kuwabara, K. Kawabata: Grating-based x-ray phase imaging using multiline x-ray source, Jpn. J. Appl. Phys. 48(7), 076512 (2009)Google Scholar
  57. Y. Du, X. Liu, Y.H. Lei, J.C. Guo, H.B. Niu: Non-absorption grating approach for x-ray phase contrast imaging, Opt. Express 19(23), 22669–22674 (2011)Google Scholar
  58. Y.H. Lei, X. Liu, J.C. Guo, Z.G. Zhao, H.B. Niu: Development of x-ray scintillator functioning also as an analyser grating used in grating-based x-ray differential phase contrast imaging, Chin. Phys. B 20(4), 042901 (2011)Google Scholar
  59. S. Rutishauser, I. Zanette, T. Donath, A. Sahlholm, J. Linnros, C. David: Structured scintillator for hard x-ray grating interferometry, Appl. Phys. Lett. 98(17), 171107 (2011)Google Scholar
  60. Y.S. Ge, K. Li, J. Garrett, G.H. Chen: Grating based x-ray differential phase contrast imaging without mechanical phase stepping, Opt. Express 22(12), 14246–14252 (2014)Google Scholar
  61. A. Momose: Demonstration of phase-contrast x-ray computed tomography using an x-ray interferometer, Nucl. Instrum. Methods Phys. Res. A 352(3), 622–628 (1995)Google Scholar
  62. I. Zanette, M. Bech, A. Rack, G. Le Duc, P. Tafforeau, C. David, J. Mohr, F. Pfeiffer, T. Weitkamp: Trimodal low-dose x-ray tomography, Proc. Natl. Acad. Sci. U.S.A. 109(26), 10199–10204 (2012)Google Scholar
  63. H. Miao, L. Chen, E.E. Bennett, N.M. Adamo, A.A. Gomella, A.M. Deluca, A. Patel, N.Y. Morgan, H. Wen: Motionless phase stepping in x-ray phase contrast imaging with a compact source, Proc. Natl. Acad. Sci. U.S.A. 110(48), 19268–19272 (2013)Google Scholar
  64. T. Koehler, H. Daerr, G. Martens, N. Kuhn, S. Loscher, U. van Stevendaal, E. Roessl: Slit-scanning differential x-ray phase-contrast mammography: Proof of concept experimental studies, Med. Phys. 42(4), 1959–1965 (2015)Google Scholar
  65. S. Bachche, M. Nonoguchi, K. Kato, M. Kageyama, T. Koike, M. Kuribayashi, A. Momose: X-ray phase scanning setup for non-destructive testing using Talbot–Lau interferometer, Proc. SPIE 9964, 99640F (2016)Google Scholar
  66. H. Wen, H. Miao, E.E. Bennett, N.M. Adamo, L. Chen: Flexible retrospective phase stepping in x-ray scatter correction and phase contrast imaging using structured illumination, PloS One 8(10), e78276 (2013)Google Scholar
  67. D. Stutman, M. Finkenthal, N. Moldovan: Development of microperiodic mirrors for hard x-ray phase-contrast imaging, Appl. Opt. 49(25), 4677–4686 (2010)Google Scholar
  68. H. Wen, C.K. Kemble, E.E. Bennett: Theory of oblique and grazing incidence Talbot–Lau interferometers and demonstration in a compact source x-ray reflective interferometer, Opt. Express 19(25), 25093–25112 (2011)Google Scholar
  69. M. Hoshino, K. Uesugi, N. Yagi: Phase-contrast x-ray microtomography of mouse fetus, Biol. Open 1, 269–274 (2012)Google Scholar
  70. A. Sarapata, J.W. Stayman, M. Finkenthal, J.H. Siewerdsen, F. Pfeiffer, D. Stutman: High energy x-ray phase contrast CT using glancing-angle grating interferometers, Med. Phys. 41(2), 021904 (2014)Google Scholar
  71. H. Miao, A. Panna, A.A. Gomella, E.E. Bennett, S. Znati, L. Chen, H. Wen: A universal moiré effect and application in x-ray phase-contrast imaging, Nat. Phys. 12(9), 830–834 (2016)Google Scholar
  72. H. Miao, A.A. Gomella, N. Chedid, L. Chen, H. Wen: Fabrication of 200 nm period hard x-ray phase gratings, Nano Lett. 14(6), 3453–3458 (2014)Google Scholar
  73. D.A. Pushin, M.G. Huber, D.S. Hussey, D.L. Jacobson, J.M. La Manna, H. Miao, D. Sarenac, H. Wen: Phase-grating interferometer for thermal and cold neutrons. In: 8th Am. Conf. Neutron Scatt., Long Beach (2016)Google Scholar
  74. M. Kagias, Z. Wang, K. Jefimovs, M. Stampanoni: Dual phase grating interferometer for tunable dark-field sensitivity, Appl. Phys. Lett. 110(1), 014105 (2017)Google Scholar
  75. J.M. Cowley, A.F. Moodie: Fourier images the phase grating, Proc. Phys. Soc. 76(489), 378–384 (1960)Google Scholar
  76. H. Miao, A.A. Gomella, K.J. Harmon, E.E. Bennett, N. Chedid, S. Znati, A. Panna, B.A. Foster, P. Bhandarkar, H. Wen: Enhancing tabletop x-ray phase contrast imaging with nano-fabrication, Sci. Rep. 5, 13581 (2015)Google Scholar
  77. G. Schulz, C. Waschkies, F. Pfeiffer, I. Zanette, T. Weitkamp, C. David, B. Müller: Multimodal imaging of human cerebellum—Merging x-ray phase microtomography, magnetic resonance microscopy and histology, Sci. Rep. 2, 826 (2012)Google Scholar
  78. M. Stampanoni, Z.T. Wang, T. Thuring, C. David, E. Roessl, M. Trippel, R.A. Kubik-Huch, G. Singer, M.K. Hohl, N. Hauser: The first analysis and clinical evaluation of native breast tissue using differential phase-contrast mammography, Invest. Radiol. 46(12), 801–806 (2011)Google Scholar
  79. S. Schleede, M. Bech, S. Grandl, A. Sztrokay, J. Herzen, D. Mayr, M. Stockmar, G. Potdevin, I. Zanette, A. Rack, T. Weitkamp, F. Pfeiffer: X-ray phase-contrast tomosynthesis for improved breast tissue discrimination, Eur. J. Radiol. 83(3), 531–536 (2014)Google Scholar
  80. T. Michel, J. Rieger, G. Anton, F. Bayer, M.W. Beckmann, J. Durst, P.A. Fasching, W. Haas, A. Hartmann, G. Pelzer, M. Radicke, C. Rauh, A. Ritter, P. Sievers, R. Schulz-Wendtland, M. Uder, D.L. Wachter, T. Weber, E. Wenkel, A. Zang: On a dark-field signal generated by micrometer-sized calcifications in phase-contrast mammography, Phys. Med. Biol. 58(8), 2713–2732 (2013)Google Scholar
  81. G. Anton, F. Bayer, M.W. Beckmann, J. Durst, P.A. Fasching, W. Haas, A. Hartmann, T. Michel, G. Pelzer, M. Radicke, C. Rauh, J. Rieger, A. Ritter, R. Schulz-Wendtland, M. Uder, D.L. Wachter, T. Weber, E. Wenkel, L. Wucherer: Grating-based darkfield imaging of human breast tissue, Z. Med. Phys. 23(3), 228–235 (2013)Google Scholar
  82. S. Schleede, F.G. Meinel, M. Bech, J. Herzen, K. Achterhold, G. Potdevin, A. Malecki, S. Adam-Neumair, S.F. Thieme, F. Bamberg, K. Nikolaou, A. Bohla, A.O. Yildirim, R. Loewen, M. Gifford, R. Ruth, O. Eickelberg, M. Reiser, F. Pfeiffer: Emphysema diagnosis using x-ray dark-field imaging at a laser-driven compact synchrotron light source, Proc. Natl. Acad. Sci. U.S.A. 109(44), 17880–17885 (2012)Google Scholar
  83. A. Yaroshenko, F.G. Meinel, M. Bech, A. Tapfer, A. Velroyen, S. Schleede, S. Auweter, A. Bohla, A.O. Yildirim, K. Nikolaou, F. Bamberg, O. Eickelberg, M.F. Reiser, F. Pfeiffer: Pulmonary emphysema diagnosis with a preclinical small-animal x-ray dark-field scatter-contrast scanner, Radiology 269(2), 426–432 (2013)Google Scholar
  84. K. Hellbach, A. Yaroshenko, F.G. Meinel, A.O. Yildirim, T.M. Conlon, M. Bech, M. Mueller, A. Velroyen, M. Notohamiprodjo, F. Bamberg, S. Auweter, M. Reiser, O. Eickelberg, F. Pfeiffer: In vivo dark-field radiography for early diagnosis and staging of pulmonary emphysema, Invest. Radiol. 50(7), 430–435 (2015)Google Scholar
  85. M. Uehara, W. Yashiro, A. Momose: Effectiveness of x-ray grating interferometry for non-destructive inspection of packaged devices, J. Appl. Phys. 114(13), 134901 (2013)Google Scholar
  86. M.S. Nielsen, L.B. Christensen, R. Feidenhans'l: Frozen and defrosted fruit revealed with x-ray dark-field radiography, Food Control 39, 222–226 (2014)Google Scholar
  87. M.P. Valdivia, D. Stutman, M. Finkenthal: Single-shot Zeff dense plasma diagnostic through simultaneous refraction and attenuation measurements with a Talbot–Lau x-ray moiré deflectometer, Appl. Opt. 54(10), 2577–2583 (2015)Google Scholar
  88. A. Tapfer, M. Bech, B. Pauwels, X. Liu, P. Bruyndonckx, A. Sasov, J. Kenntner, J. Mohr, M. Walter, J. Schulz, F. Pfeiffer: Development of a prototype gantry system for preclinical x-ray phase-contrast computed tomography, Med. Phys. 38(11), 5910–5915 (2011)Google Scholar
  89. A. Momose, W. Yashiro, K. Kido, J. Kiyohara, C. Makifuchi, T. Ito, S. Nagatsuka, C. Honda, D. Noda, T. Hattori, T. Endo, M. Nagashima, J. Tanaka: X-ray phase imaging: From synchrotron to hospital, Philos. Trans. R. Soc. A 372, 20130023 (2010)Google Scholar
  90. T.J. Davis, D. Gao, T.E. Gureyev, A.W. Stevenson, S.W. Wilkins: Phase-contrast imaging of weakly absorbing materials using hard x-rays, Nature 373(6515), 595–598 (1995)Google Scholar
  91. D. Chapman, W. Thomlinson, R.E. Johnston, D. Washburn, E. Pisano, N. Gmur, Z. Zhong, R. Menk, F. Arfelli, D. Sayers: Diffraction enhanced x-ray imaging, Phys. Med. Biol. 42(11), 2015–2025 (1997)Google Scholar
  92. Z. Zhong, W. Thomlinson, D. Chapman, D. Sayers: Implementation of diffraction-enhanced imaging experiments: At the NSLS and APS, Nucl. Instrum. Methods Phys. Res. A 450(2/3), 556–567 (2000)Google Scholar
  93. E.D. Pisano, R.E. Johnston, D. Chapman, J. Geradts, M.V. Iacocca, C.A. Livasy, D.B. Washburn, D.E. Sayers, Z. Zhong, M.Z. Kiss, W.C. Thomlinson: Human breast cancer specimens: Diffraction-enhanced imaging with histologic correlation—Improved conspicuity of lesion detail compared with digital radiography, Radiology 214(3), 895–901 (2000)Google Scholar
  94. B.W. Batterman, H. Cole: Dynamical diffraction of x-rays by perfect crystals, Rev. Mod. Phys. 36(3), 681–717 (1964)Google Scholar
  95. E. Pagot, P. Cloetens, S. Fiedler, A. Bravin, P. Coan, J. Baruchel, J. Hartwig, W. Thomlinson: A method to extract quantitative information in analyzer-based x-ray phase contrast imaging, Appl. Phys. Lett. 82(20), 3421–3423 (2003)Google Scholar
  96. C. Parham, Z. Zhong, D.M. Connor, L.D. Chapman, E.D. Pisano: Design and implementation of a compact low-dose diffraction enhanced medical imaging system, Acad. Radiol. 16(8), 911–917 (2009)Google Scholar
  97. I. Nesch, D.P. Fogarty, T. Tzvetkov, B. Reinhart, A.C. Walus, G. Khelashvili, C. Muehleman, D. Chapman: The design and application of an in-laboratory diffraction-enhanced x-ray imaging instrument, Rev. Sci. Instrum. 80(9), 093702 (2009)Google Scholar
  98. M. Ando, N. Sunaguchi, Y.L. Wu, S. Do, Y.J. Sung, A. Louissaint, T. Yuasa, S. Ichihara, R. Gupta: Crystal analyser-based x-ray phase contrast imaging in the dark field: Implementation and evaluation using excised tissue specimens, Eur. Radiol. 24(2), 423–433 (2014)Google Scholar
  99. S. Gasilov, A. Mittone, E. Brun, A. Bravin, S. Grandl, P. Coan: On the possibility of quantitative refractive-index tomography of large biomedical samples with hard x-rays, Biomed. Opt. Express 4(9), 1512–1518 (2013)Google Scholar
  100. M.O. Hasnah, Z. Zhong, O. Oltulu, E.D. Pisano, R.E. Johnston, D. Sayers, W. Thomlinson, D. Chapman: Diffraction enhanced imaging contrast mechanisms in breast cancer specimens, Med. Phys. 29(10), 2216–2221 (2002)Google Scholar
  101. M. Fernandez, J. Keyrilainen, R. Serimaa, M. Torkkeli, M.L. Karjalainen-Lindsberg, M. Leidenius, K. von Smitten, M. Tenhunen, S. Fiedler, A. Bravin, T.M. Weiss, P. Suortti: Human breast cancer in vitro: Matching histo-pathology with small-angle x-ray scattering and diffraction enhanced x-ray imaging, Phys. Med. Biol. 50(13), 2991–3006 (2005)Google Scholar
  102. L. Faulconer, C. Parham, D.M. Connor, Z. Zhong, E. Kim, D.L. Zeng, C. Livasy, E. Cole, C. Kuzmiak, M. Koomen, D. Pavic, E. Pisano: Radiologist evaluation of an x-ray tube-based diffraction-enhanced imaging prototype using full-thickness breast specimens, Acad. Radiol. 16(11), 1329–1337 (2009)Google Scholar
  103. T. Kao, D. Connor, F.A. Dilmanian, L. Faulconer, T. Liu, C. Parham, E.D. Pisano, Z. Zhong: Characterization of diffraction-enhanced imaging contrast in breast cancer, Phys. Med. Biol. 54(10), 3247–3256 (2009)Google Scholar
  104. Y.Z. Zhao, E. Brun, P. Coan, Z.F. Huang, A. Sztrokay, P.C. Diemoz, S. Liebhardt, A. Mittone, S. Gasilov, J.W. Miao, A. Bravin: High-resolution, low-dose phase contrast x-ray tomography for 3-D diagnosis of human breast cancers, Proc. Natl. Acad. Sci. U.S.A. 109(45), 18290–18294 (2012)Google Scholar
  105. C. Muehleman, J. Li, Z. Zhong, J.G. Brankov, M.N. Wernick: Multiple-image radiography for human soft tissue, J. Anat. 208(1), 115–124 (2006)Google Scholar
  106. C. Muehleman, J. Li, D. Connor, C. Parham, E. Pisano, Z. Zhong: Diffraction-enhanced imaging of musculoskeletal tissues using a conventional x-ray tube, Acad. Radiol. 16(8), 918–923 (2009)Google Scholar
  107. M.N. Wernick, O. Wirjadi, D. Chapman, Z. Zhong, N.P. Galatsanos, Y.Y. Yang, J.G. Brankov, O. Oltulu, M.A. Anastasio, C. Muehleman: Multiple-image radiography, Phys. Med. Biol. 48(23), 3875–3895 (2003)Google Scholar
  108. J. Li, Z. Zhong, R. Lidtke, K.E. Kuettner, C. Peterfy, E. Aliyeva, C. Muehleman: Radiography of soft tissue of the foot and ankle with diffraction enhanced imaging, J. Anat. 202(5), 463–470 (2003)Google Scholar
  109. R.A. Lewis, C.J. Hall, A.P. Hufton, S. Evans, R.H. Menk, F. Arfelli, L. Rigon, G. Tromba, D.R. Dance, I.O. Ellis, A. Evans, E. Jacobs, S.E. Pinder, K.D. Rogers: X-ray refraction effects: Application to the imaging of biological tissues, Br. J. Radiol. 76(905), 301–308 (2003)Google Scholar
  110. N. Zhu, D. Chapman, D. Cooper, D.J. Schreyer, X.B. Chen: X-ray diffraction enhanced imaging as a novel method to visualize low-density scaffolds in soft tissue engineering, Tissue Eng. C 17(11), 1071–1080 (2011)Google Scholar
  111. Z. Izadifar, A. Honaramooz, S. Wiebe, G. Belev, X.B. Chen, D. Chapman: Low-dose phase-based x-ray imaging techniques for in situ soft tissue engineering assessments, Biomaterials 82, 151–167 (2016)Google Scholar
  112. U. Bonse, M. Hart: An x-ray interferometer, Appl. Phys. Lett. 6(8), 155–156 (1965)Google Scholar
  113. U. Bonse, M. Hart: Moiré patterns of atomic planes obtained by x-ray interferometry, Z. Phys. 190(4), 455–467 (1966)Google Scholar
  114. L. Zehnder: Ein neuer Interferenzrefraktor, Z. Instrum. 11, 275–285 (1891)Google Scholar
  115. A. Momose, A. Fukuda: Phase-contrast radiographs of nonstained rat cerebellar specimen, Med. Phys. 22(4), 375–379 (1995)Google Scholar
  116. F. Beckmann, U. Bonse, F. Busch, O. Gunnewig: X-ray microtomography (\(\upmu\)CT) using phase contrast for the investigation of organic matter, J. Comput. Assist. Tomogr. 21(4), 539–553 (1997)Google Scholar
  117. A. Yoneyama, T. Takeda, Y. Tsuchiya, J. Wu, T.L. Thet, A. Koizumi, K. Hyodo, Y. Itai: A phase-contrast x-ray imaging system—with a \(60\times 30\) mm field of view—based on a skew-symmetric two-crystal x-ray interferometer, Nucl. Instrum. Methods Phys. Res. A 523(1/2), 217–222 (2004)Google Scholar
  118. T. Takeda, A. Yoneyama, J. Wu, T.L. Thet, A. Momose, K. Hyodo: In vivo physiological saline-infused hepatic vessel imaging using a two-crystal-interferometer-based phase-contrast x-ray technique, J. Synchrotron Radiat. 19, 252–256 (2012)Google Scholar
  119. A. Momose, T. Takeda, Y. Itai, K. Hirano: Phase-contrast x-ray computed tomography for observing biological soft tissues, Nat. Med. 2(4), 473–475 (1996)Google Scholar
  120. C. David, B. Nohammer, H.H. Solak, E. Ziegler: Differential x-ray phase contrast imaging using a shearing interferometer, Appl. Phys. Lett. 81(17), 3287–3289 (2002)Google Scholar
  121. H. Wen, A.A. Gomella, A. Patel, S.K. Lynch, N.Y. Morgan, S.A. Anderson, E.E. Bennett, X. Xiao, C. Liu, D.E. Wolfe: Subnanoradian x-ray phase-contrast imaging using a far-field interferometer of nanometric phase gratings, Nat. Commun. 4, 2659 (2013)Google Scholar
  122. H. Wen, A.A. Gomella, A. Patel, D.E. Wolfe, S.K. Lynch, X. Xiao, N.Y. Morgan: Boosting phase contrast with a grating Bonse–Hart interferometer of 200 nanometre grating period, Philos. Trans. R. Soc. A 372(2010), 20130028 (2014)Google Scholar

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© Springer Nature Switzerland AG 2019

Authors and Affiliations

  1. 1.National Heart, Lung and Blood InstituteNational Institutes of HealthBethesda, MDUSA

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