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Adult-Onset Still's Disease

  • Michael H. Weisman

Abstract

Adult-onset Still's disease (AOSD) was described originally by Eric Bywaters in 1971. AOSD closely resembles systemic-onset juvenile idio-pathic arthritis, a pediatric disorder known originally as Still's disease. An intensely inflammatory, multiorgan system disorder characterized by a polyarthritis, high spiking fevers, and an evanescent, salmon-colored rash (Figs. 3.1a–c). The rash is described as small macules that disappear during the night but reappear the next day, usually coincident with a fever spike. Peripheral joint involvement can be fleeting but also may settle into a refractory, destructive arthritis marked by a tendency in some joints for fusion. AOSD is typically seronegative. Patients do not have rheumatoid factor or antibodies to cyclic citrullinated peptides. Other common features are leukocytosis, thrombocy-tosis, elevations of the serum hepatic aminotransferase concentrations, splenomegaly, and serositis. Pharyngitis is often the initial symptom.

Keywords

Juvenile Idiopathic Arthritis Interstitial Lung Disease Familial Mediterranean Fever Juvenile Rheumatoid Arthritis Serum Ferritin Level 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media B.V. 2009

Authors and Affiliations

  • Michael H. Weisman
    • 1
  1. 1.Division of RheumatologyCedars Sinai Medical CenterLos AngelesUSA

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