Pulmonary Surfactant: Biology and Therapy

  • Douglas F. Willson
  • Patricia R. Chess
  • Zhengdong Wang
  • Robert H. Notter


Respir Crit Surfactant Protein Lamellar Body Pulmonary Surfactant Lung Surfactant 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


  1. 1.
    von Neergaard K. Neue auffassungen uber einen grundbegriff der atemmechanik. Dieretraktionskraft der lunge, abhangig von der oberflachenspannung in den alveolen. Z Ges Exp Med 1929;66:373–394.CrossRefGoogle Scholar
  2. 2.
    Gruenwald P. Surface tension as a factor in the resistance of neonatal lungs to aeration. Am J Obstet Gynecol 1947;53:996–1007.PubMedGoogle Scholar
  3. 3.
    Mead J, Whittenberger JL, Radford EP. Surface tension as a factor in pulmonary volume–pressure hysteresis. J Appl Physiol 1957;10:191– 196.PubMedGoogle Scholar
  4. 4.
    Pattle RE. Properties, function, and origin of the alveolar lining layer. Nature 1955;175:1125–1126.PubMedCrossRefGoogle Scholar
  5. 5.
    Clements JA. Surface tension of lung extracts. Proc Soc Exp Biol Med 1957;95:170–172.PubMedGoogle Scholar
  6. 6.
    Brown ES. Lung area from surface tension effects. Proc Soc Exp Biol Med 1957;95:168–170.PubMedGoogle Scholar
  7. 7.
    Pattle RE. Properties, function and origin of the alveolar lining layer. Proc R Soc (Lond) Ser B 1958;148:217–240.CrossRefGoogle Scholar
  8. 8.
    Avery ME, Mead J. Surface properties in relation to atelectasis and hyaline membrane disease. Am J Dis Child 1959;97:517–523.Google Scholar
  9. 9.
    Robillard E, Alarie Y, Dagenais-Perusse P, Baril E, Guilbeault A. Microaerosol administration of synthetic b,g-dipalmitoyl-L-a- lecithin in the respiratory distress syndrome: a preliminary report. Can Med Assoc J 1964;90:55–57.PubMedGoogle Scholar
  10. 10.
    Chu J, Clements JA, Cotton EK, Klaus MH, Sweet AY, Thomas MA, Tooley WH. The pulmonary hypoperfusion syndrome. Pediatrics 1965;35:733–742.PubMedGoogle Scholar
  11. 11.
    Chu J, Clements JA, Cotton EK, Klaus MH, Sweet AY, Tooley WH. Neonatal pulmonary ischemia. Clinical and physiologic studies. Pediatrics 1967;40:709–782.PubMedGoogle Scholar
  12. 12.
    Notter RH. Lung Surfactants: Basic Science and Clinical Applications. New York: Marcel Dekker; 2000.Google Scholar
  13. 13.
    Fujiwara T, Maeta H, Chida S, Morita T, Watabe Y, Abe T. Artificial surfactant therapy in hyaline membrane disease. Lancet 1980;1:55–59.PubMedCrossRefGoogle Scholar
  14. 14.
    Wang Z, Baatz JE, Holm BA, Notter RH. Content-dependent activity of lung surfactant protein B (SP-B) in mixtures with lipids. Am J Physiol 2002;283:L897–L906.Google Scholar
  15. 15.
    Wang Z, Gurel O, Baatz JE, Notter RH. Differential activity and lack of synergy of lung surfactant proteins SP-B and SP-C in surface-active interactions with phospholipids. J Lipid Res 1996;37:1749–1760.PubMedGoogle Scholar
  16. 16.
    Seeger W, Günther A, Thede C. Differential sensitivity to fibrinogen inhibition of SP-C- vs. SP-B-based surfactants. Am J Physiol 1992;261:L286–L291.Google Scholar
  17. 17.
    Notter RH, Wang Z. Pulmonary surfactant: physical chemistry, physiology and replacement. Rev Chem Eng 1997;13:1–118.CrossRefGoogle Scholar
  18. 18.
    Notter RH, Wang Z, Egan EA, Holm BA. Component-specific surface and physiological activity in bovine-derived lung surfactants. Chem Phys Lipids 2002;114:21–34.PubMedCrossRefGoogle Scholar
  19. 19.
    Whitsett JA, Nogee LM, Weaver TE, Horowitz AD. Human surfactant protein B structure, function, regulation, and genetic disease. Physiol Rev 1995;75:749–757.PubMedGoogle Scholar
  20. 20.
    deMello DE, Nogee LM, Heyman S, Krous HF, Hussain M, Merritt TA, Hsueh W, Haas JE, Heidelberger K, Schumacher R, Colten HR. Molecular and phenotypic variability in the congenital alveolar proteinosis syndrome associated with inherited surfactant protein B deficiency. J Pediatr 1994;125:43–50.PubMedCrossRefGoogle Scholar
  21. 21.
    Nogee LM, Garnier G, Dietz HC, Singer L, Murphy AM, deMello DE, Colten HR. A mutation in the surfactant protein B gene responsible for fatal neonatal respiratory disease in multiple kindreds. J Clin Invest 1994;93:1860–1863.PubMedCrossRefGoogle Scholar
  22. 22.
    Nogee LM, Wert SE, Proffit SA, Whitsett JA. Allelic heterogeneity in hereditary surfactant protein B (SP-B) deficiency. Am J Respir Crit Care Med 2000;161:973–981.PubMedGoogle Scholar
  23. 23.
    Nogee LM, Dunbar AE, Wert SE, Askin F, Hamvas A, Whitsett JA. A mutation in the surfactant protein C gene associated with familial interstitial lung disease. N Engl J Med 2001;344:573–579.PubMedCrossRefGoogle Scholar
  24. 24.
    Crouch E, Wright JR. Surfactant proteins A and D and pulmonary host defense. Annu Rev Physiol 2001;63:521–554.PubMedCrossRefGoogle Scholar
  25. 25.
    Lawson PR, Reid KBM. The roles of surfactant proteins A and D in innate immunity. Immunol Rev 2000;173:66–78.PubMedCrossRefGoogle Scholar
  26. 26.
    Mason RJ, Greene K, Voelker DR. Surfactant protein A and surfactant protein D in health and disease. Am J Physiol 1998;275:L1–L13.PubMedGoogle Scholar
  27. 27.
    Wright JR. Immunomodulatory functions of surfactant. Physiol Rev 1997;77:931–962.PubMedGoogle Scholar
  28. 28.
    LeVine AM, Bruno MD, Huelsman KM, Ross GF, Whitsett JA. Surfactant protein A deficient mice are susceptible to group B streptococcal infection. J Immunol 1997;158:4336–4340.PubMedGoogle Scholar
  29. 29.
    LeVine AM, Kurak KE, Bruno MD, Stark JM, Whitsett JA, Korfhagen TA. Surfactant protein A–deficient mice are susceptible to Pseudomonas aeruginosa infection. Am J Respir Cell Mol Biol 1998;19: 700–708.PubMedGoogle Scholar
  30. 30.
    Korfhagen TR, Sheftelyevich V, Burhans MS, Bruno MD, Ross GF, et al. Surfactant protein D regulates surfactant phospholipid homeostasis in vivo. J Biol Chem 1998;273:28438–28443.PubMedCrossRefGoogle Scholar
  31. 31.
    Lim BL, Wang JY, Holmskov U, Hoppe HJ, Reid KB. Expression of the carbohydrate recognition domain of lung surfactant protein D and demonstration of its binding to lipopolysaccharides of Gram-negative bacteria. Biochem Biophys Res Commun 1994;202:1674–1680.PubMedCrossRefGoogle Scholar
  32. 32.
    Ferguson JS, Voelker DR, McCormack FX, Schlesinger LS. Surfactant protein D binds to Mycobacterium tuberculosis bacilli and liparabinomannan via carbohydrate-lectin interactions resulting in reduced phagocytosis of the bacteria by the macrophages. J Immunol 1999; 163:312–321.PubMedGoogle Scholar
  33. 33.
    Wright JR. Clearance and recycling of pulmonary surfactant. Am J Physiol 1990;259:L1–L12.PubMedGoogle Scholar
  34. 34.
    Batenburg JJ. Surfactant phospholipids: synthesis and storage. Am J Physiol 1992;262:L367–L385.PubMedGoogle Scholar
  35. 35.
    Hawgood S. Surfactant: composition, structure, and metabolism. In: Crystal RG, West JB, Weibel ER, Barnes PJ, eds. The Lung: Scientific Foundations, 2nd ed. Philadelphia: Lippincott-Raven; 1997:557– 571.Google Scholar
  36. 36.
    Hawgood S, Poulain FR. The pulmonary collectins and surfactant metabolism. Annu Rev Physiol 2001;63:495–519.PubMedCrossRefGoogle Scholar
  37. 37.
    van Golde LMG, Casals CC. Metabolism of lipids. In: Crystal RG, West JB, Weibel ER, Barnes PJ, eds. The Lung: Scientific Foundations, 2nd ed. Philadelphia: Lippincott-Raven; 1997:9–18.Google Scholar
  38. 38.
    Haagsman HP, van Golde LMG. Synthesis and assembly of lung surfactant. Annu Rev Physiol 1991;53:441–464.PubMedCrossRefGoogle Scholar
  39. 39.
    Johansson J, Curstedt T, Robertson B. The proteins of the surfactant system. Eur Respir J 1994;7:372–391.PubMedCrossRefGoogle Scholar
  40. 40.
    Rooney SA, Young SL, Mendelson CR. Molecular and cellular processing of lung surfactant. FASEB J 1994;8:957–967.PubMedGoogle Scholar
  41. 41.
    Mendelson CR, Alcorn JL, Gao E. The pulmonary surfactant protein genes and their regulation in fetal lung. Semin Perinatol 1993;17:223– 232.PubMedGoogle Scholar
  42. 42.
    Oosterlaken-Dijksterhuis MA, van Eijk M, van Buel BLM, van Golde LMG, Haagsman HP. Surfactant protein composition of lamellar bodies isolated from rat lung. Biochem J 1991;274:115–119.PubMedGoogle Scholar
  43. 43.
    O’Reilly MA, Nogee L, Whitsett JA. Requirement of the collagenous domain for carbohydrate processing and secretion of a surfactant protein, SP-A. Biochim Biophys Acta 1988;969:176–184.PubMedCrossRefGoogle Scholar
  44. 44.
    Pinto RA, Wright JR, Lesikar D, Benson BJ, Clements JA. Uptake of pulmonary surfactant protein C into adult rat lung lamellar bodies. J Appl Physiol 1993;74:1005–1011.PubMedGoogle Scholar
  45. 45.
    Walker SR, Williams MC, Benson B. Immunocytochemical localization of the major surfactant proteins in type II cells, Clara cells, and alveolar macrophages of rat lungs. J Histochem Cytochem 1986;34:1137– 1148.PubMedCrossRefGoogle Scholar
  46. 46.
    Weaver TE, Whitsett JA. Processing of hydrophobic pulmonary surfactant protein B in rat type II cells. Am J Physiol 1989;257:L100–L108.PubMedGoogle Scholar
  47. 47.
    Vorhout WF, Veenendaal T, Kuroki Y, Ogasawara Y, van Golde LMG, Geuze HJ. Immunocytochemical localization of surfactant protein D (SP-D) in type II cell, Clara cells, and alveolar macrophages of rat lung. J Histochem Cytochem 1992;40:1589–1597.CrossRefGoogle Scholar
  48. 48.
    Crouch E, Rust K, Marienchek W, Parghi D, Chang D, Persson A. Developmental expression of pulmonary surfactant protein D (SP-D). Am J Respir Cell Mol Biol 1991;5:13–18.PubMedGoogle Scholar
  49. 49.
    Williams MC. Conversion of lamellar body membranes into tubular myelin in alveoli of fetal rat lungs. J Cell Biol 1977;72:260–277.PubMedCrossRefGoogle Scholar
  50. 50.
    Williams MC. Ultrastructure of tubular myelin and lamellar bodies in fast-frozen rat lung. Exp Lung Res 1982;4:37–46.PubMedCrossRefGoogle Scholar
  51. 51.
    Williams MC, Hawgood S, Hamilton RL. Changes in lipid structure produced by surfactant proteins SP-A, SP-B, and SP-C. Am J Respir Cell Mol Biol 1991;5:41–50.PubMedGoogle Scholar
  52. 52.
    Suzuki Y, Fujita Y, Kogishi K. Reconstitution of tubular myelin from synthetic lipids and proteins associated with pig lung surfactant. Am Rev Respir Dis 1989;140:75–81.PubMedCrossRefGoogle Scholar
  53. 53.
    Wright JR, Clements JA. Metabolism and turnover of lung surfactant. Am Rev Respir Dis 1987;135:426–444.CrossRefGoogle Scholar
  54. 54.
    Jobe AH, Ikegami M. Surfactant metabolism. Clin Perinatol 1993;20:683– 696.PubMedGoogle Scholar
  55. 55.
    Williams MC. Uptake of lectins by alveolar type II cells: subsequent deposition into lamellar bodies. Proc Natl Acad Sci USA 1984;81: 6383–6387.PubMedCrossRefGoogle Scholar
  56. 56.
    Wright JR, Wager RE, Hamilton RL, Huang M, Clements JA. Uptake of lung surfactant subfractions into lamellar bodies of adult rabbit lungs. J Appl Physiol 1986;60:817–825.PubMedGoogle Scholar
  57. 57.
    Wright JR, Wager RE, Hawgood S, Dobbs LG, Clements JA. Surfactant apoprotein Mr = 26,000–36,000 enhances uptake of liposomes by type II cells. J Biol Chem 1987;262:2888–2894.PubMedGoogle Scholar
  58. 58.
    Young SL, Wright JR, Clements JA. Cellular uptake and processing of surfactant lipids and apoprotein SP-A by rat lung. J Appl Physiol. 1989;66:1336–1342.PubMedGoogle Scholar
  59. 59.
    Claypool WD, Wang DL, Chandler A, Fisher AB. An ethanol/ether soluble apoprotein from rat lung surfactant augments liposomes uptake by isolated granular pneumocytes. J Clin Invest 1984;74:677–684.PubMedCrossRefGoogle Scholar
  60. 60.
    Rice WR, Sarin VK, Fox JL, Baatz J, Wert S, Whitsett JA. Surfactant peptides stimulate uptake of phosphatidylcholine by isolated cells. Biochim Biophys Acta 1989;1006:237–245.PubMedGoogle Scholar
  61. 61.
    Notter RH, Finkelstein JN, Holm BA. Lung Injury: Mechanisms, Pathophysiology, and Therapy. Boca Raton, FL: Taylor & Francis; 2005:847.Google Scholar
  62. 62.
    Ashbaugh DG, Bigelow DB, Petty TL, Levine BE. Acute respiratory distress in adults. Lancet 1967;2:319–323.PubMedCrossRefGoogle Scholar
  63. 63.
    Petty TL, Ashbaugh DG. The adult respiratory distress syndrome. Clinical features, factors influencing prognosis and principles of management. Chest 1971;60:233–239.PubMedCrossRefGoogle Scholar
  64. 64.
    Petty T, Reiss O, Paul G, Silvers G, Elkins N. Characteristics of pulmonary surfactant in adult respiratory distress syndrome associated with trauma and shock. Am Rev Respir Dis 1977;115:531–536.PubMedGoogle Scholar
  65. 65.
    Wang Z, Holm BA, Matalon S, Notter RH. Surfactant activity and dysfunction in lung injury. In: Notter RH, Finkelstein JN, Holm BA, eds. Lung injury: Mechanisms, Pathophysiology, and Therapy. New York: Marcel Dekker; 2005:297–352.Google Scholar
  66. 66.
    Holm BA, Enhorning G, Notter RH. A biophysical mechanism by which plasma proteins inhibit lung surfactant activity. Chem Phys Lipids 1988;49:49–55.PubMedCrossRefGoogle Scholar
  67. 67.
    Holm BA, Wang Z, Notter RH. Multiple mechanisms of lung surfactant inhibition. Pediatr Res 1999;46:85–93.PubMedCrossRefGoogle Scholar
  68. 68.
    Holm BA, Notter RH. Effects of hemoglobin and cell membrane lipids on pulmonary surfactant activity. J Appl Physiol 1987;63:1434–1442.PubMedGoogle Scholar
  69. 69.
    Wang Z, Notter RH. Additivity of protein and non-protein inhibitors of lung surfactant activity. Am J Respir Crit Care Med 1998;158: 28–35.PubMedGoogle Scholar
  70. 70.
    Hall SB, Lu ZR, Venkitaraman AR, Hyde RW, Notter RH. Inhibition of pulmonary surfactant by oleic acid: mechanisms and characteristics. J Appl Physiol 1992;72:1708–1716.PubMedGoogle Scholar
  71. 71.
    Pison U, Tam EK, Caughey GH, Hawgood S. Proteolytic inactivation of dog lung surfactant-associated proteins by neutrophil elastase. Biochim Biophys Acta 1989;992:251–257.PubMedGoogle Scholar
  72. 72.
    Enhorning G, Shumel B, Keicher L, Sokolowski J, Holm BA. Phospholipases introduced into the hypophase affect the surfactant film outlining a bubble. J Appl Physiol 1992;73:941–945.PubMedGoogle Scholar
  73. 73.
    Wang Z, Schwan AL, Lairson LL, O’Donnell JS, Byrne GF, Foye A, Holm BA, Notter RH. Surface activity of a synthetic lung surfactant containing a phospholipase-resistant phosphonolipid analog of dipalmitoyl phosphatidylcholine. Am J Physiol 2003;285:L550–L559.Google Scholar
  74. 74.
    Magoon MW, Wright JR, Baritussio A, Williams MC, Goerke J, Benson BJ, Hamilton RL, Clements JA. Subfractionation of lung surfactant: implications for metabolism and surface activity. Biochim Biophys Acta 1983;750:18–31.PubMedGoogle Scholar
  75. 75.
    Wright JR, Benson BJ, Williams MC, Goerke J, Clements JA. Protein composition of rabbit alveolar surfactant subfractions. Biochim Biophys Acta 1984;791:320–332.PubMedCrossRefGoogle Scholar
  76. 76.
    Gross NJ, Narine KR. Surfactant subtypes in mice: characterization and quantitation. J Appl Physiol 1989;66:342–349.PubMedCrossRefGoogle Scholar
  77. 77.
    Hall SB, Hyde RW, Notter RH. Changes in subphase surfactant aggregates in rabbits injured by free fatty acid. Am J Respir Crit Care Med 1994;149:1099–1106.PubMedGoogle Scholar
  78. 78.
    Putz G, Goerke J, Clements JA. Surface activity of rabbit pulmonary surfactant subfractions at different concentrations in a captive bubble. J Appl Physiol 1994;77:597–605.PubMedGoogle Scholar
  79. 79.
    Putman E, Creuwels LAJM, Van Golde LMG, Haagsman HP. Surface properties, morphology and protein composition of pulmonary surfactant subtypes. Biochem J 1996;320:599–605.PubMedGoogle Scholar
  80. 80.
    Veldhuizen RAW, Hearn SA, Lewis JF, Possmayer F. Surface-area cycling of different surfactant preparations: SP-A and SP-B are essential for large aggregate integrity. Biochem J 1994;300:519–524.PubMedGoogle Scholar
  81. 81.
    Gross NJ. Extracellular metabolism of pulmonary surfactant: the role of a new serine protease. Ann Rev Physiol 1995;57:135–150.CrossRefGoogle Scholar
  82. 82.
    Günther A, Siebert C, Schmidt R, Ziegle S, Grimminger F, Yabut M, Temmesfeld B, Walmrath D, Morr H, Seeger W. Surfactant alterations in severe pneumonia, acute respiratory distress syndrome, and cardiogenic lung edema. Am J Respir Crit Care Med 1996;153:176– 184.PubMedGoogle Scholar
  83. 83.
    Veldhuizen R, McCaig L, Akino T, Lewis J. Pulmonary surfactant subfractions in patients with the acute respiratory distress syndrome. Am J Respir Crit Care Med 1995;152:1867–1871.PubMedGoogle Scholar
  84. 84.
    Griese M. Pulmonary surfactant in health and human lung diseases: state of the art. Eur Respir J 1999;13:1455–1476.PubMedCrossRefGoogle Scholar
  85. 85.
    Pison U, Seeger W, Buchhorn R, Joka T, Brand M, Obertacke U, Neuhof H, Schmit-Neuerberg K. Surfactant abnormalities in patients with respiratory failure after multiple trauma. Am Rev Respir Dis 1989;140:1033–1039.PubMedGoogle Scholar
  86. 86.
    Lewis JF, Ikegami M, Jobe AH. Altered surfactant function and metabolism in rabbits with acute lung injury. J Appl Physiol 1990;69:2303– 2310.PubMedGoogle Scholar
  87. 87.
    Putman E, Boere AJ, van Bree L, van Golde LMG, Haagsman HP. Pulmonary surfactant subtype metabolism is altered after short-term ozone exposure. Toxicol Appl Pharmacol 1995;134:132–138.PubMedCrossRefGoogle Scholar
  88. 88.
    Atochina EN, Beers MF, Scanlon ST, Preston AM, Beck JM. P. carinii induces selective alterations in component expression and biophysical activity of lung surfactant. Am J Physiol 2000;278:L599–L609.Google Scholar
  89. 89.
    Davidson BA, Knight PR, Wang Z, Chess PR, Holm BA, Russo TA, Hutson A, Notter RH. Surfactant alterations in acute inflammatory lung injury from aspiration of acid and gastric particulates. Am J Physiol Lung Cell Mol Physiol 2005;288:L699–708.PubMedCrossRefGoogle Scholar
  90. 90.
    Seeger W, Pison U, Buchhorn R, Obestacke U, Joka T. Surfactant abnormalities and adult respiratory failure. Lung 1990;168(Suppl): 891–902PubMedCrossRefGoogle Scholar
  91. 91.
    Gregory TJ, Longmore WJ, Moxley MA, Whitsett JA, Reed CR, Fowler AA, Hudson LD, Maunder RJ, Crim C, Hyers TM. Surfactant chemical composition and biophysical activity in acute respiratory distress syndrome. J Clin Invest 1991;88:1976–1981.PubMedCrossRefGoogle Scholar
  92. 92.
    Pison U, Obertacke U, Brand M, et al. Altered pulmonary surfactant in uncomplicated and septicemia-complicated courses of acute respiratory failure. J Trauma 1990;30:19–26.PubMedCrossRefGoogle Scholar
  93. 93.
    Hallman M, Spragg R, Harrell JH, Moser KM, Gluck L. Evidence of lung surfactant abnormality in respiratory failure. J Clin Invest 1982;70:673–683.PubMedCrossRefGoogle Scholar
  94. 94.
    Anzueto A, Baughman RP, Guntupalli KK, Weg JG, Wiedemann HP, Raventos AA, Lemaire F, Long W, Zaccardelli DS, Pattishall EN, Exosurf ARDS Sepsis Study Group. Aerosolized surfactant in adults with sepsis- induced acute respiratory distress syndrome. N Engl J Med 1996;334:1417–1421.PubMedCrossRefGoogle Scholar
  95. 95.
    Hall SB, Venkitaraman AR, Whitsett JA, Holm BA, Notter RH. Importance of hydrophobic apoproteins as constituents of clinical exogenous surfactants. Am Rev Respir Dis 1992;145:24–30.PubMedCrossRefGoogle Scholar
  96. 96.
    Seeger W, Grube C, Günther A, Schmidt R. Surfactant inhibition by plasma proteins: differential sensitivity of various surfactant preparations. Eur Respir J 1993;6:971–977.PubMedGoogle Scholar
  97. 97.
    Hudak ML, Farrell EE, Rosenberg AA, Jung AL, Auten RL, Durand DJ, Horgan MJ, Buckwald S, Belcastro MR, Donohue PK, Carrion V, Maniscalco WM, Balsan MJ, Torres BA, Miller RR, Jansen RD, Graeber JE, Laskay KM, Matteson EJ, Egan EA, Brody AS, Martin DJ, Riddlesberger MM, Montogomery P, 21 Center Group. A multicenter randomized masked comparison of natural vs synthetic surfactant for the treatment of respiratory distress syndrome. J Pediatr 1996;128: 396–406.PubMedCrossRefGoogle Scholar
  98. 98.
    Hudak ML, Martin DJ, Egan EA, Matteson EJ, Cummings J, Jung AL, Kimberlin LV, Auten RL, Rosenberg AA, Asselin JM, Belcastro MR, Donahue PK, Hamm CR, Jansen RD, Brody AS, Riddlesberger MM, Montgomery P, 10 Center Group. A multicenter randomized masked comparison trial of synthetic surfactant versus calf lung surfactant extract in the prevention of neonatal respiratory distress syndrome. Pediatrics 1997;100:39–50.PubMedCrossRefGoogle Scholar
  99. 99.
    Vermont-Oxford Neonatal Network. A multicenter randomized trial comparing synthetic surfactant with modified bovine surfactant extract in the treatment of neonatal respiratory distress syndrome. Pediatrics 1996;97:1–6.Google Scholar
  100. 100.
    Horbar JD, Wright LL, Soll RF, Wright EC, Fanaroff AA, Korones SB, Shankaran S, Oh W, Fletcher BD, Bauer CR, NIH NICHHD Neonatal Research Network. A multicenter randomized trial comparing two surfactants for the treatment of neonatal respiratory distress syndrome. J Pediatr 1993;123:757–766.PubMedCrossRefGoogle Scholar
  101. 101.
    Willson DF. Calfactant. Expert Opin Pharmacother 2001;2:1479– 1493.PubMedCrossRefGoogle Scholar
  102. 102.
    Wiseman LR, Bryson HM. Porcine-Derived Lung Surfactant. A review of the therapeutic efficacy and clinical tolerability of a natural surfactant preparation (Curosurf) in neonatal respiratory distress syndrome. Drugs 1994;48:387–400.Google Scholar
  103. 103.
    Mizuno K, Ikegami M, Chen C-M, Ueda T, Jobe AH. Surfactant protein-B supplementation improves in vivo function of a modified natural surfactant. Pediatr Res 1995;37:271–276.PubMedCrossRefGoogle Scholar
  104. 104.
    Walther FJ, Hernandez-Juviel J, Bruni R, Waring A. Spiking Survanta with synthetic surfactant peptides improves oxygenation in surfactant-deficient rats. Am J Respir Crit Care Med 1997;156:855–861.PubMedGoogle Scholar
  105. 105.
    Hamvas A, Cole FS, deMello DE, Moxley M, Whitsett JA, Colten HR, Nogee LM. Surfactant protein B deficiency: antenatal diagnosis and prospective treatment with surfactant replacement. J Pediatr 1994;125:356–361.PubMedCrossRefGoogle Scholar
  106. 106.
    Yu SH, Possmayer F. Comparative studies on the biophysical activities of the low-molecular-weight hydrophobic proteins purified from bovine pulmonary surfactant. Biochim Biophys Acta 1988;961:337– 350.PubMedGoogle Scholar
  107. 107.
    Oosterlaken-Dijksterhuis MA, van Eijk M, van Golde LMG, Haagsman HP. Lipid mixing is mediated by the hydrophobic surfactant protein SP-B but not by SP-C. Biochim Biophys Acta 1992;1110:45–50.PubMedCrossRefGoogle Scholar
  108. 108.
    Kobayashi T, Ganzuka M, Taniguchi J, Nitta K, Murakami S. Lung lavage and surfactant replacement for hydrochloric acid aspiration in rabbits. Acta Anaesthesiol Scand 1990;34:216–221.PubMedCrossRefGoogle Scholar
  109. 109.
    Zucker A, Holm BA, Wood LDH, Crawford G, Ridge K, Sznajder IA. Exogenous surfactant with PEEP reduces pulmonary edema and improves lung function in canine aspiration pneumonitis. J Appl Physiol 1992;73:679–686.PubMedGoogle Scholar
  110. 110.
    Schlag G, Strohmaier W. Experimental aspiration trauma: com-parison of steroid treatment versus exogenous natural surfactant. Exp Lung Res 1993;19:397–405.PubMedCrossRefGoogle Scholar
  111. 111.
    Al-Mateen KB, Dailey K, Grimes MM, Gutcher GR. Improved oxygenation with exogenous surfactant administration in experimental meconium aspiration syndrome. Pediatr Pulmonol 1994;17:75–80.PubMedCrossRefGoogle Scholar
  112. 112.
    Sun B, Curstedt T, Robertson B. Exogenous surfactant improves ventilation efficiency and alveolar expansion in rats with meconium aspiration. Am J Respir Crit Care Med 1996;154:764–770.PubMedGoogle Scholar
  113. 113.
    Cochrane CG, Revak SD, Merritt TA, Schraufstatter U, Hoch RC, Henderson C, Andersson S, Takamori H, Oades ZG. Bronchoalveolar lavage with KL4-surfactant in models of meconium aspiration syndrome. Pediatr Res 1998;44:705–715.PubMedCrossRefGoogle Scholar
  114. 114.
    Sun B, Curstedt T, Song GW, Robertson B. Surfactant improves lung function and morphology in newborn rabbits with meconium aspiration. Biol Neonate 1993;63:96–104.PubMedCrossRefGoogle Scholar
  115. 115.
    Lachmann B, Hallman M, Bergman K-C. Respiratory failure following anti-lung serum: study on mechanisms associated with surfactant system damage. Exp Lung Res 1987;12:163–180.PubMedCrossRefGoogle Scholar
  116. 116.
    Nieman G, Gatto L, Paskanik A, Yang B, Fluck R, Picone A. Surfactant replacement in the treatment of sepsis-induced adult respiratory distress syndrome in pigs. Crit Care Med 1996;24:1025–1033.PubMedCrossRefGoogle Scholar
  117. 117.
    Lutz C, Carney D, Finck C, Picone A, Gatto L, Paskanik A, Langenbeck E, Nieman G. Aerosolized surfactant improves pulmonary function in endotoxin-induced lung injury. Am J Respir Crit Care Med 1998;158: 840–845.PubMedGoogle Scholar
  118. 118.
    Lutz CJ, Picone A, Gatto LA, Paskanik A, Landas S, Nieman G. Exogenous surfactant and positive end-expiratory pressure in the treatment of endotoxin-induced lung injury. Crit Care Med 1998;26:1379– 1389.PubMedCrossRefGoogle Scholar
  119. 119.
    Tashiro K, Li W-Z, Yamada K, Matsumoto Y, Kobayashi T. Surfactant replacement reverses respiratory failure induced by intratracheal endotoxin in rats. Crit Care Med 1995;23:149–156.PubMedCrossRefGoogle Scholar
  120. 120.
    Eijking EP, van Daal GJ, Tenbrinck R, Luyenduijk A, Sluiters JF, Hannappel E, Lachmann B. Effect of surfactant replacement on Pneumocystis carinii pneumonia in rats. Intensive Care Med 1990;17:475– 478.CrossRefGoogle Scholar
  121. 121.
    Sherman MP, Campbell LA, Merritt TA, Long WA, Gunkel JH, Curstedt T, Robertson B. Effect of different surfactants on pulmonary group B streptococcal infection in premature rabbits. J Pediatr 1994;125:939– 947.PubMedCrossRefGoogle Scholar
  122. 122.
    Berry D, Ikegami M, Jobe A. Respiratory distress and surfactant inhibition following vagotomy in rabbits. J Appl Physiol. 1986;61:1741– 1748.PubMedGoogle Scholar
  123. 123.
    Matalon S, Holm BA, Notter RH. Mitigation of pulmonary hyperoxic injury by administration of exogenous surfactant. J Appl Physiol1987;62:756–761.PubMedGoogle Scholar
  124. 124.
    Loewen GM, Holm BA, Milanowski L, Wild LM, Notter RH, Matalon S. Alveolar hyperoxic injury in rabbits receiving exogenous surfactant. J Appl Physiol 1989;66:1987–1992.Google Scholar
  125. 125.
    Engstrom PC, Holm BA, Matalon S. Surfactant replacement attenuates the increase in alveolar permeability in hyperoxia. J Appl Physiol 1989;67:688–693.PubMedGoogle Scholar
  126. 126.
    Matalon S, Holm BA, Loewen GM, Baker RR, Notter RH. Sublethal hyperoxic injury to the alveolar epithelium and the pulmonary surfactant system. Exp Lung Res 1988;14:1021–1033.PubMedCrossRefGoogle Scholar
  127. 127.
    Novotny WE, Hudak BB, Matalon S, Holm BA. Hyperoxic lung injury reduces exogenous surfactant clearance in vitro. Am J Respir Crit Care Med 1995;151:1843–1847.PubMedGoogle Scholar
  128. 128.
    Lachmann B, Fujiwara T, Chida S, Morita T, Konishi M, Nakamura K, Maeta H. Surfactant replacement therapy in experimental adult respiratory distress syndrome (ARDS). In: Cosmi EV, Scarpelli EM, eds. Pulmonary Surfactant System. Amsterdam: Elsevier; 1983:221– 235.Google Scholar
  129. 129.
    Kobayashi T, Kataoka H, Ueda T, Murakami S, Takada Y, Kobuko M. Effect of surfactant supplementation and end expiratory pressure in lung-lavaged rabbits. J Appl Physiol 1984;57:995–1001.PubMedGoogle Scholar
  130. 130.
    Berggren P, Lachmann B, Curstedt T, Grossmann G, Robertson B. Gas exchange and lung morphology after surfactant replacement in experimental adult respiratory distress induced by repeated lung lavage. Acta Anaesthesiol Scand 1986;30:321–328.PubMedCrossRefGoogle Scholar
  131. 131.
    Lewis JF, Goffin J, Yue P, McCaig LA, Bjarneson D, Veldhuizen RAW. Evaluation of exogenous surfactant treatment strategies in an adult model of acute lung injury. J Appl Physiol 1996;80:1156–1164.PubMedCrossRefGoogle Scholar
  132. 132.
    Walther F, Hernandez-Juviel J, Bruni R, Waring AJ. Protein composition of synthetic surfactant affects gas exchange in surfactant- deficient rats. Pediatr Res 1998;43:666–673.PubMedCrossRefGoogle Scholar
  133. 133.
    Harris JD, Jackson F, Moxley MA, Longmore WJ. Effect of exogenous surfactant instillation on experimental acute lung injury. J Appl Physiol 1989;66:1846–1851.PubMedGoogle Scholar
  134. 134.
    Lewis JF, Ikegami M, Jobe AH. Metabolism of exogenously administered surfactant in the acutely injured lungs of adult rabbits. Am Rev Respir Dis 1992;145:19–23.PubMedCrossRefGoogle Scholar
  135. 135.
    Lewis J, Ikegami M, Higuchi R, Jobe A, Absolom D. Nebulized vs. instilled exogenous surfactant in an adult lung injury model. J Appl Physiol 1991;71:1270–1276.PubMedGoogle Scholar
  136. 136.
    van Daal GJ, So KL, Gommers D, Eijking EP, Fievez RB, Sprenger MJ, van Dam DW, Lachmann B. Intratracheal surfactant administration restores gas exchange in experimental adult respiratory distress syndrome associated with viral pneumonia. Anesth Analg 1991;72:589– 595.PubMedCrossRefGoogle Scholar
  137. 137.
    van Daal GJ, Bos JAH, Eijking EP, Gommers D, Hannappel E, Lachmann B. Surfactant replacement therapy improves pulmonary mechanics in end-stage influenza A pneumonia in mice. Am Rev Respir Dis 1992;145:859–863.PubMedGoogle Scholar
  138. 138.
    Gunther A, Schmidt R, Harodt J, Schmehl T, et al. Bronchoscopic administration of bovine natural surfactant in ARDS and septic shock: impact on biophysical and biochemical surfactant properties. Eur Respir J 2002;10:797–804.CrossRefGoogle Scholar
  139. 139.
    Walmrath D, Gunther A, Ghofrani HA, Schermuly R, Schnedier T, Grimminger F, Seeger W. Bronchoscopic surfactant administration in patients with severe adult respiratory distress syndrome and sepsis. Am J Respir Crit Care Med 1996;154:57–62.PubMedGoogle Scholar
  140. 140.
    Spragg RG, Gilliard N, Richman P, et al. Acute effects of a single dose of porcine surfactant on patients with acute respiratory distress syndrome. Chest. 1995;105:195–202.CrossRefGoogle Scholar
  141. 141.
    Wiswell TE, Smith RM, Katz LB, Mastroianni L, Wong DY, Willms D, Heard S, Wilson M, Hite RD, Anzueto A, Revak SD, Cochrane CG. Bronchopulmonary segmental lavage with Surfaxin (KL(4)—surfactant) for acute respiratory distress syndrome. Am J Respir Crit Care Med 1999;160:1188–1195.PubMedGoogle Scholar
  142. 142.
    Willson DF, Jiao JH, Bauman LA, Zaritsky A, Craft H, Dockery K, Conrad D, Dalton H. Calf lung surfactant extract in acute hypoxemic respiratory failure in children. Crit Care Med 1996;24:1316–1322.PubMedCrossRefGoogle Scholar
  143. 143.
    Willson DF, Bauman LA, Zaritsky A, Dockery K, James RL, Stat M, Conrad D, Craft H, Novotny WE, Egan EA, Dalton H. Instillation of calf lung surfactant extract (calfactant) is beneficial in pediatric acute hypoxemic respiratory failure. Crit Care Med 1999;27:188–195.PubMedCrossRefGoogle Scholar
  144. 144.
    Willson DF, Thomas NJ, Markovitz BP, Bauman LA, DiCarlo JV, Pon S, Jacobs BR, Jefferson LS, Conaway MR, Egan EA, Pediatric Acute Lung Injury and Sepsis Investigators. Effect of exogenous surfactant (calfactant) in pediatric acute lung injury: a randomized controlled trial. JAMA 2005;293:470–476.PubMedCrossRefGoogle Scholar
  145. 145.
    Lopez-Herce J, de Lucas N, Carrillo A, Bustinza A, Moral R. Surfactant treatment for acute respiratory distress syndrome. Arch Dis Child 1999;80:248–252.PubMedCrossRefGoogle Scholar
  146. 146.
    Hermon MM, Golej J, Burda H, et al. Surfactant therapy in infants and children: three years experience in a pediatric intensive care unit. Shock 2002;17:247–251.PubMedCrossRefGoogle Scholar
  147. 147.
    Herting E, Moller O, Schiffman JH, Robertson B. Surfactant improves oxygenation in infants and children with pneumonia and acute respiratory distress syndrome. Acta Paediatr 2002;91:1174–1178.PubMedCrossRefGoogle Scholar
  148. 148.
    Auten RL, Notter RH, Kendig JW, Davis JM, Shapiro DL. Surfactant treatment of full-term newborns with respiratory failure. Pediatrics 1991;87:101–107.PubMedGoogle Scholar
  149. 149.
    Lotze A, Knight GR, Martin GR, Bulas DI, Hull WM, O’Donnell RM, Whitsett JA, Short BL. Improved pulmonary outcome after exogenous surfactant therapy for respiratory failure in term infants requiring extracorporeal membrane oxygenation. J Pediatr 1993;122:261–268.PubMedCrossRefGoogle Scholar
  150. 150.
    Lotze A, Mitchell BR, Bulas DI, Zola EM, Shalwitz RA, Gunkel JH. Multicenter study of surfactant (beractant) use in the treatment of term infants with severe respiratory failure. J Pediatr 1998;132: 40–47.PubMedCrossRefGoogle Scholar
  151. 151.
    Khammash H, Perlman M, Wojtulewicz J, Dunn M. Surfactant therapy in full-term neonates with severe respiratory failure. Pediatrics 1993;92:135–139.PubMedGoogle Scholar
  152. 152.
    Findlay RD, Taeusch HW, Walther FJ. Surfactant replacement therapy for meconium aspiration syndrome. Pediatrics 1996;97:48–52.PubMedGoogle Scholar
  153. 153.
    Luchetti M, Casiraghi G, Valsecchi R, Galassini E, Marraro G. Porcine-derived surfactant treatment of severe bronchiolitis. Acta Anaesthesiol Scand 1998;42:805–810.PubMedCrossRefGoogle Scholar
  154. 154.
    Luchetti M, Ferrero F, Gallini C, Natale A, Pigna A, Tortorolo L, Marraro G. Multicenter, randomized, controlled study of porcine surfactant in severe respiratory syncytial virus–induced respiratory failure. Pediatr Crit Care Med 2002;3:261–268.PubMedCrossRefGoogle Scholar
  155. 155.
    Gregory TJ, Steinberg KP, Spragg R, Gadek JE, Hyers TM, Longmere WJ, Moxley MA, Guang-Zuan CAI, Hite RD, Smith RM, Hudson LD, Crim C, Newton P, Mitchell BR, Gold AJ. Bovine surfactant therapy for patients with acute respiratory distress syndrome. Am J Respir Crit Care Med 1997;155:109–131.Google Scholar
  156. 156.
    Clark DA, Nieman GF, Thompson JE, Paskanik AM, Rokhar JE, Bredenberg CE. Surfactant displacement by meconium free fatty acids: an alternative explanation for atelectasis in meconium aspiration syndrome. J Pediatr 1987;110:765–770.PubMedCrossRefGoogle Scholar
  157. 157.
    Moses D, Holm BA, Spitale P, Liu M, Enhorning G. Inhibition of pulmonary surfactant function by meconium. Am J Obstet Gynecol 1991;164:477–481.PubMedGoogle Scholar
  158. 158.
    Ivascu FA, Hirschl RB. New approaches to managing congenital diaphragmatic hernia. Semin Perinatol 2004;28:185–198.PubMedCrossRefGoogle Scholar
  159. 159.
    Van Meurs K, The Congenital Diaphragmatic Hernia Study Group. Is surfactant therapy beneficial in the treatment of the term newborn infants with congenital diaphragmatic hernia? J Pediatr 2004;145: 312–316.PubMedCrossRefGoogle Scholar
  160. 160.
    Spragg RG, Lewis JF, Wurst W, Hafner D, Baughman RP, Wewers MD, Marsh JJ. Treatment of acute respiratory distress syndrome with recombinant surfactant protein C surfactant. Am J Respir Crit Care Med 2003;167:1562–1566.PubMedCrossRefGoogle Scholar
  161. 161.
    Moller JC, Schaible T, Roll C, et al. with the Surfactant ARDS Study Group. Treatment with bovine surfactant in severe acute respiratory distress syndrome in children: a randomized multicenter study. Intensive Care Med 2003;29:437–446.PubMedGoogle Scholar
  162. 162.
    Kendig JW, Notter RH, Cox C, Reubens LJ, Davis JM, Maniscalco WM, Sinkin RA, Bartoletti A, Dweck HS, Horgan MJ, Risemberg H, Phelps DL, Shapiro DL. A comparison of surfactant as immediate prophylaxis and as rescue therapy in newborns of less than 30 weeks gestation. N Engl J Med 1991;324:865–871.PubMedCrossRefGoogle Scholar
  163. 163.
    Notter RH, Apostolakos M, Holm BA, Willson D, Wang Z, Finkelstein JN, Hyde RW. Surfactant therapy and its potential use with other agents in term infants, children and adults with acute lung injury. Perspect Neonatol 2000;1(4):4–20.Google Scholar
  164. 164.
    Pryhuber G, D’angio C, Finkelstein JN, Notter RH. Combination therapies for lung injury. In: Notter RH, Finkelstein JN, Holm BA, eds. Lung Injury: Mechanisms, Pathophysiology, and Therapy. Boca Raton, FL: Taylor 8 Francis; 2005:779– 838.Google Scholar

Copyright information

© Springer-Verlag London 2009

Authors and Affiliations

  • Douglas F. Willson
    • 1
  • Patricia R. Chess
    • 2
  • Zhengdong Wang
    • 3
  • Robert H. Notter
    • 4
  1. 1.University of Virginia Health Sciences Center Director, Division of Pediatric Critical Care University of Virginia Children’s Medical CenterCharlottesvilleUSA
  2. 2.Division of Neonatology Golisano Children’s Hospital at Strong RochesterUniversity of Rochester Medical CenterRochesterUSA
  3. 3.Department of PediatricsUniversity of Rochester Medical CentreRochesterUSA
  4. 4.University of Rochester Medical Center Golisano Children’s Hospital at Strong RochesterRochesterUSA

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