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The Aging Adipose Organ: Lipid Redistribution, Inflammation, and Cellular Senescence

  • Michael B. Stout
  • Tamara Tchkonia
  • James L. KirklandEmail author
Chapter
Part of the Nutrition and Health book series (NH)

Abstract

White adipose tissue (WAT) is an immensely plastic organ that plays a vital role in regulating metabolic homeostasis and systemic inflammation. Advancing age mitigates the dynamic nature of WAT which promotes the manifestation of several lipodystrophic-associated comorbidities. Inflammation and the accumulation of senescence cells likely play a key role in this process by inhibiting adipogenesis. The reduction of WAT functional capacity with aging and the role that inflammation and cellular senescence may play in this process will be explored throughout this review.

Keywords

Aging Cellular senescence Inflammation White adipose tissue 

Notes

Acknowledgements

This work was supported by NIH grants AG13925 (JLK), AG31736 (A. Bartke), and AG41122 (JLK), the Robert and Arlene Kogod Center on Aging, and the Noaber, Glenn, and Ellison Foundations.

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Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  • Michael B. Stout
    • 1
  • Tamara Tchkonia
    • 1
  • James L. Kirkland
    • 1
    Email author
  1. 1.Mayo ClinicRobert & Arlene Kogod Center on AgingRochesterUSA

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