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Parkinson’s Disease Treated with Deep Brain Stimulation

  • Roongroj Bhidayasiri
  • Daniel Tarsy
Chapter
Part of the Current Clinical Neurology book series (CCNEU)

Abstract

Deep brain stimulation (DBS) is currently the surgical treatment of choice for patients with intermediate or advanced Parkinson’s disease (PD) who are experiencing levodopa-related motor complications such as motor fluctuations, dyskinesias, and dystonias (see Chap. 5) which can no longer be successfully managed with antiparkinson medications. In double-blind trials, subthalamic (STN) and globus pallidus (GPi) DBS have been found to be approximately equally effective for reducing levodopa response fluctuations and improving dyskinesias in patients with advanced PD. STN-DBS allows for the dose of antiparkinson medications to be reduced, while following GPi-DBS, a direct antidyskinetic effect of DBS is achieved, but levodopa must be continued to maintain antiparkinson effects.

Keywords

Deep Brain Stimulation Protein Intake Facial Masking Executive Dysfunction Motor Fluctuation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Supplementary material

PD treated w. DBS.mp4 (MP4 32,800KB)

Clip 1: 12 h off levodopa, with DBS off, there is severe akinesia of arms in fixed elevated position, marked facial masking, and jaw-opening dystonia. Rapid finger tapping in left hand and toe tapping in both feet are hypokinetic. Clip 2: 90 min after levodopa, with DBS on, facial masking persists but without jaw dystonia and elevation of arms. Rapid finger tapping in left hand is improved, and toe tapping is still hypokinetic. Gait is shuffling without armswing. Clip 3: on another day, while on levodopa and with DBS on, facial expression and voice are normal, gait is brisk with normal armswing, and rapid finger and hand movements are normal.

References

  1. 1.
    Deuschl G, Schade-Brittinger C, Krack P, et al. A randomized trial of deep-brain stimulation for Parkinson’s disease. N Engl J Med. 2006;355:896–908.PubMedCrossRefGoogle Scholar
  2. 2.
    Weaver F, Follett K, Stern M, et al. Bilateral deep brain stimulation vs best medical therapy for patients with advanced Parkinson disease. JAMA. 2009;301:63–73.PubMedCentralPubMedCrossRefGoogle Scholar
  3. 3.
    Follett K, Weaver FM, Stern M, et al. Pallidal versus subthalamic deep-brain stimulation for Parkinson’s disease. N Engl J Med. 2010;362:2077–91.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2012

Authors and Affiliations

  • Roongroj Bhidayasiri
    • 1
    • 2
  • Daniel Tarsy
    • 3
  1. 1.Chulalongkorn Center of Excellence on Parkinson’s Disease and Related DisordersChulalongkorn University HospitalBangkokThailand
  2. 2.Department of NeurologyDavid Geffen School of Medicine at UCLALos AngelesUSA
  3. 3.Department of NeurologyHarvard Medical School Beth Israel Deaconess Medical CenterBostonUSA

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