• Steven E. LoEmail author
  • Steven J. Frucht
Part of the Current Clinical Neurology book series (CCNEU)


Myoclonus is defined as sudden, brief, nonsustained involuntary jerks [1]. Often described as “lightning-like” or “shock-like,” the speed of myoclonus separates it from other hyperkinetic movements. Myoclonus is a clinical sign resulting from abnormal neuronal activation, which leads to either muscle contraction (positive myoclonus) or the inhibition of muscle contractions (negative myoclonus). The differential diagnosis of myoclonus is broad, and therefore, a careful investigation of underlying sources is required.


Deep Brain Stimulation Video Segment Myoclonic Epilepsy Sodium Oxybate Myoclonic Jerk 
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Supplementary material

CASES 1-15: Myoclonus (wmv 107,369 KB)


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© Springer Science+Business Media New York 2012

Authors and Affiliations

  1. 1.Department of NeurologyGeorgetown University HospitalWashingtonUSA
  2. 2.Department of NeurologyMount Sinai Medical CenterNew YorkUSA

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