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Current Role of Anthracyclines in the Treatment of Multiple Myeloma

  • Sikander Ailawadhi
  • Asher Chanan-Khan
Part of the Contemporary Hematology book series (CH)

Introduction

Anthracyclines are an important class of antineoplastic drugs that have undergone extensive preclinical and clinical evaluation in various neoplastic disorders including multiple myeloma (MM). They remain an important ingredient in various therapeutic regimens for several hematologic cancers with major impact as part of combination chemotherapy regimens. In MM, anthracy-clines (doxorubicin) remain an integral part of the frontline VA D (vincristine, doxorubicin, and dexamethasone) regimen, which is one of the most common antimyeloma regimens used worldwide. This chapter will thus focus on the current role of anthracyclines in the management of patients with MM.

Pharmacology

Anthracyclines are naturally occurring antibiotics that are derived from actinobacteria Streptomyces peucetius var. caesius. Daunorubicin was the first agent to be discovered in this category that demonstrated antitumor activity in murine model system of human cancers. Further development of this class...

Keywords

Overall Survival Multiple Myeloma Maximum Tolerate Dose Overall Response Rate Pegylated Liposomal Doxorubicin 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media, LLC 2008

Authors and Affiliations

  • Sikander Ailawadhi
    • 1
  • Asher Chanan-Khan
    • 1
  1. 1.Department of MedicineRoswell Park Cancer InstituteBuffaloUSA

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