Role of Autologous Stem Cell Transplantation in Multiple Myeloma

  • Jean-Luc Harousseau
Part of the Contemporary Hematology book series (CH)


High-dose therapy (HDT) with autologous stem cell transplantation (ASCT) was introduced in the treatment of multiple myeloma (MM) 20 years ago1,2and its role is still controversial. The use of peripheral blood stem cells instead of bone marrow has markedly improved feasibility and for newly diagnosed MM transplant-related mortality is 1–2% in fit patients with a normal renal function and younger than 65 years. In this group of patients, randomized studies have shown the superiority of ASCT compared with conventional chemotherapy. Therefore, until now, ASCT is considered the standard of care in this population of patients. However, it is currently challenged by the introduction of novel agents such as thalidomide, bortezomib, and lenalidomide. When they are used in combination with dexamethasone or with chemotherapy, these agents appear to yield results that are comparable to those achieved with ASCT. The question is now to determine whether novel agents should replace...


Overall Survival Multiple Myeloma Complete Remission Autologous Stem Cell Transplantation Conventional Chemotherapy 
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Copyright information

© Springer Science+Business Media, LLC 2008

Authors and Affiliations

  • Jean-Luc Harousseau
    • 1
  1. 1.Centre Hospitalier Universitaire Hotel-DieuPlace Alexis RicordeauFrance

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