Lenalidomide for Initial Therapy of Newly Diagnosed Multiple Myeloma

  • Shaji Kumar
Part of the Contemporary Hematology book series (CH)


Multiple myeloma (MM) is the second most common hematologic malignancy after non-Hodgkin'slymphoma, and over 19,000 individuals were estimated to be diagnosed with this disease in 2007, with nearly 12,000 myeloma-related deaths during this time period.1 It is characterized by accumulation of clonal plasma cells in the bone marrow that secrete a monoclonal protein in the majority and usually presents with destructive bone lesions, anemia, hyper-calcemia, and/or renal insufficiency.2 Conventional therapy with alkylating agents and steroids or other chemotherapy combinations result in a median survival of 3–4 years, which is prolonged by nearly a year with high-dose therapy and stem cell rescue.2, 3, 4Myeloma is believed to be incurable with the current approaches, but several new promising therapies have been introduced in the past few years that have vastly improved the treatment options for these patients. These include the immunomodulatory derivatives of tha-lidomide...


Multiple Myeloma Stem Cell Transplant Myeloma Cell Area Under Curve Very Good Partial Response 
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Copyright information

© Springer Science+Business Media, LLC 2008

Authors and Affiliations

  • Shaji Kumar
    • 1
  1. 1.Mayo ClinicRochesterUSA

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