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Future Directions for Research on Biotherapeutic Agents

Contribution of Genetic Approaches on Lactic Acid Bacteria
  • Gerard Corthier
  • Pierre Renault
Chapter

Abstract

Genetic tools have significantly contributed to increasing our knowledge in two fields related to biotherapeutic agents (BTA): bacterial physiology and the control of protein expression. The most striking example of an application in this new domain is the use of invasive, but nonpathogenic Salmonella with the ability to interact with lymphoid tissue in the Peyer’s patches (1). These mutants have been shown to be an effective means of stimulating mucosal secretory IgA directed against a variety of heterologous antigens. However, these attenuated pathogens may not be acceptable in the elderly and very young, since they may translocate from the digestive tract to invade the host. Nevertheless, this demonstrates the applicability and potential of genetic engineering in expanding the applications of BTA.

Keywords

Lactic Acid Bacterium Digestive Tract Heterologous Protein Fermented Milk Lactococcus Lactis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1999

Authors and Affiliations

  • Gerard Corthier
  • Pierre Renault

There are no affiliations available

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