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The Chemokine Gene Family

Similar Structures, Diverse Functions
  • Vicki L. Schweickart
  • Carol J. Raport
  • David Chantry
  • Patrick W. Gray
Chapter
  • 43 Downloads
Part of the Contemporary Immunology book series (CONTIM)

Abstract

Our understanding of the function of chemokines has been reshaped over the past few years because of the large number of new chemokines recently discovered. Earlier reviews on chemokine structure and function presented a relatively simple picture of the chemokine family: a handful of CXC and CC chemokines, whose genes clustered on chromosomes 4 and 17, respectively, involved in the recruitment of leukocyte subsets to sites of inflammation (1,2). Over the past few years, however, the use of computer technology to search vast libraries of randomly sequenced cDNAs has brought to light many novel chemokines that complicate the picture described above, but also enrich our understanding of the functional diversity of chemokines. Not only have new chemokine families and chromoobtained, and how they have broadened our understanding of the structure and function of chemokines.

Keywords

Chemokine Receptor Leukocyte Subset Chemokine Family Orphan GPCRs Thymic Dendritic Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1999

Authors and Affiliations

  • Vicki L. Schweickart
  • Carol J. Raport
  • David Chantry
  • Patrick W. Gray

There are no affiliations available

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