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Reactive Astrogliosis in the Injured and Postischemic Brain

  • Ronald Jabs
  • Lane K. Bekar
  • Wolfgang Walz
Chapter
Part of the Contemporary Neuroscience book series (CNEURO)

Abstract

Reactive astrocytes appear within days of a disturbance or injury to the brain. They form part of a gliotic or scar tissue, which can take on a very complex form, depending on the type and intensity of the disturbance. Reactive astrocytes are usually characterized by morphological changes and increases in intermediate filaments. However, other more functional characteristics are not as well-characterized. In particular, glial interactions with surviving neurones are not very well-defined. Some attention has been paid to glial upregulation of protective factors and changes in expression of extracellular matrix, but changes in membrane properties and homeostatic mechanisms have received very little regard. This is true for injury in general, but is especially true following ischemic injury.

Keywords

Nerve Growth Factor Glutamine Synthetase Reactive Astrocyte Neural Cell Adhesion Molecule Kainic Acid 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1999

Authors and Affiliations

  • Ronald Jabs
  • Lane K. Bekar
  • Wolfgang Walz

There are no affiliations available

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