Cytokines in Severe Head Injury

  • Linda Ott
  • Craig McClain
  • Stephen Scheff
  • Jimmi Hatton
  • Byron Young
Part of the Contemporary Neuroscience book series (CNEURO)


During the 1970s and early 1980s the morbidity and mortality rate from severe head injury significantly decreased. There still are patients who succumb to this severe injury or survive with poor recovery. Currently, about 30% survive with poor recovery, and this rate of poor outcome has not significantly changed during the past decade (1). In an effort to improve the outcome further, investigators have started to study intensively the type of damage inflicted by secondary factors that lead to secondary injury, and those caused by systemic effects of brain injury. Factors that block these negative effects are being developed and studied in an attempt to improve patient outcome. It is our hypothesis that cytokines play an important role in the metabolic response to head injury and that medical intervention that modulates the cytokine response may improve the adverse metabolic effects of head injury. The present chapter focuses on the role of cytokines in the metabolic response to head injury. Specifically, we will present evidence for increased cytokine levels and biologic effects following clinical and experimental brain injury. We will show that cytokine infusion mimics the systemic response to brain injury, and we will discuss potential roles of cytokine modulation following brain injury.


Gastric Emptying Head Injury Severe Head Injury Serum Zinc Level Tumour Necrosis Factor Level 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 1998

Authors and Affiliations

  • Linda Ott
  • Craig McClain
  • Stephen Scheff
  • Jimmi Hatton
  • Byron Young

There are no affiliations available

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