Clinical Applications of G-CSF and GM-CSF in the Treatment of Infectious Diseases

  • Kai Hübel
  • David C. Dale
  • Richard K. Root
  • W. Conrad Liles
Part of the Infectious Disease book series (ID)


Infectious diseases remain a major cause of morbidity and mortality throughout the world, including the United States. The immune system represents the primary host defense against pathogenic bacteria, fungi, and parasites. The first line of defense is comprised primarily of polymorphnuclear granulocytes (PMNs), macrophages, natural killer (NK) cells, and cytotoxic lymphocytes. Upon activation, these cells can destroy and eliminate pathogenic microorganisms. The possibility of augmenting host defense has increased dramatically during the past two decades with the discovery and development of cytokines. The immunomodulatory effects of colony-stimulating factors (CSFs) on selected leukocyte populations have received increasing attention recently.


Oral Mucositis Granulocyte Transfusion Severe Chronic Neutropenia Buffy Coat Cell Recombinant Human Granulocyte Colony 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 2003

Authors and Affiliations

  • Kai Hübel
  • David C. Dale
  • Richard K. Root
  • W. Conrad Liles

There are no affiliations available

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