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Asthma, Infection, and Environment

  • Laurel J. Gershwin
Chapter
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Abstract

  • The immune response of neonates has a natural bias towards a T helper cell type 2 (Th2) cytokine profile.

  • Th2 cytokines facilitate development of allergic sensitization.

  • Exposure to infectious agents during early childhood is thought to modulate development of allergic sensitization and asthma.

  • Respiratory syncytial virus, influenza virus, rhinovirus, and parainfluenza viruses have been associated with wheezing during early childhood and have been implicated in induction of asthma.

  • Respiratory syncytial virus has been shown to induce an IgE response, particularly in atopic children.

  • Infection with non-viral agents such as Mycoplasma pneumoniae and Chylamydia pneumoniae is associated with asthma in adults.

  • Results from studies with a murine model show that exposure to environmental tobacco smoke facilitates allergic sensitization to inhaled allergens through production of T helper cell type 2 cytokines.

  • Results from studies with a murine model show that exposure to ozone facilitates allergic sensitization to inhaled allergen.

  • Studies in humans and mice show that diesel exhaust particles increase local IgE production in response to allergen.

  • Ozone and environmental tobacco smoke exposure stimulate airway hyperresponsiveness in a guinea pig model.

Keywords

Respiratory Syncytial Virus Allergic Asthma Environmental Tobacco Smoke Maternal Smoking Respiratory Syncytial Virus Infection 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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  • Laurel J. Gershwin

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