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Chromatin Epigenomics in Muscle Development and Disease

  • Jelena PerovanovicEmail author
Chapter
Part of the Methods in Physiology book series (METHPHYS)

Abstract

Epigenomic approaches use genome-wide tools to characterize the reversible modifications of DNA or DNA-associated proteins (chromatin) and identify regulatory factors that shape epigenomic landscape. The status of the epigenomic landscape is a major regulator of gene expression, and it is central for specification of muscle fate. The epigenomic landscape is influenced by both genetic and environmental factors, and these changes exhibit a high degree of plasticity. Some modifications are long lasting and are needed to convey cell identity over time, while others can be more transient in order to provide rapid adaptation to environmental cues. Here we review relevant epigenomic tools commonly used to study chromatin biology in the context of muscle development and pathology.

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Copyright information

© The American Physiological Society 2019

Authors and Affiliations

  1. 1.Huntsman Cancer InstituteUniversity of Utah School of MedicineSalt Lake CityUSA

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