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Pathology of the Gastrointestinal Tract and Exocrine Pancreas

  • Mark J. Hoenerhoff
  • Arun Kumar R. PandiriEmail author
Chapter
  • 132 Downloads

Abstract

Xenobiotic-induced adverse effects in the alimentary system can result in a significant liability in drug development as well as after environmental exposures. Many of these adverse effects are manifested as functional disturbances such as nausea and diarrhea, but with increased exposures (dose or time), there can be morphological changes resulting in various nonneoplastic and neoplastic conditions. As the first site of exposure to ingested substances, the alimentary system serves as the first line of defense against xenobiotic exposure, and the target organs of injury or carcinogenesis depend not only on the xenobiotic but also on the animal model being used. Significant species differences in anatomy and physiology require an understanding of how these differences relate to human health risk, as well as to appropriate model selection for preclinical or hazard identification studies. This chapter will focus on the functional anatomy and physiology, background, and species-specific pathology of various species used in preclinical studies. In addition, various background and test article-related lesions in various organs in the alimentary system such as the oral cavity, salivary glands, esophagus, stomach, small and large intestine, and exocrine pancreas will be discussed. Additionally, discussion of various animal models used to study test article-related effects and recapitulate gastrointestinal disease in humans will be reviewed.

Key words

Alimentary Pathology Toxicology Gastrointestinal Oral cavity Salivary gland Esophagus Stomach Small intestine Large intestine Exocrine pancreas Animal models 

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  1. 1.In Vivo Animal Core, Unit for Laboratory Animal MedicineUniversity of Michigan Medical SchoolAnn ArborUSA
  2. 2.Molecular Pathology Group, Division of the National Toxicology ProgramNational Institute of Environmental Health SciencesResearch TriangleUSA

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