Pathology of Juvenile Animals

  • Catherine A. PicutEmail author
  • Amera K. Remick


To cover the broad topic of juvenile pathology, an overview of the regulatory landscape and explanation regarding when and why pathologists examine juvenile tissues in preclinical safety studies are provided. There are unique challenges and opportunities associated with examining juvenile tissues, and these collectively help determine the safety of test articles and shed light on mechanism of action. Delving into selected organ systems, salient or unique features of normal development are discussed, with emphasis on those features that provide opportunity to help design targeted studies as well as those morphologic features that can complicate evaluation. In addition, for each organ, special pathology procedures utilized on juvenile tissues, toxic lesions that have been published in the relevant literature, and spontaneous diseases that may be encountered are highlighted.

Key words

Anatomy & Histology Biological Availability Biotransformation Drug Therapy Growth & Development Juvenile Laboratory Animals Pathology Regulations Toxicology 


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Authors and Affiliations

  1. 1.Charles River Laboratories, Inc.DurhamUSA

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