Herpes Simplex Viruses 1 and 2, Varicella Zoster Virus, and Human Herpes Viruses 6, 7, and 8 in Transplant Recipients

  • Raymund R. RazonableEmail author


Human herpes viruses are a family of double-stranded DNA viruses that cause opportunistic infections in solid organ and hematopoietic stem cell transplant recipients. Alpha-herpesviruses cause localized ulcerative mucosal and vesicular cutaneous lesions, with the tendency to disseminate if not treated early and aggressively. Beta-herpes viruses, discussed in this chapter such as human herpes viruses 6 and 7, may rarely cause a febrile illness and a skin rash; however, HHV6 in recipients of allogeneic HSCT is well recognized to cause serious illness including viral hepatitis, encephalitis, and myelosuppression including loss of stem cell graft. The gamma-herpesvirus, HHV-8, causes Kaposi’s sarcoma and body cavity lymphoma, among other rare diseases mostly seen in patients with HIV/AIDS. This chapter will review the epidemiology, clinical diseases, diagnosis, prevention, and treatment of six of the eight members of the human herpesvirus family, including HSV-1, HSV-2, VZV, HHV-6A and HHV-6B, HHV-7, and HHV-8.


Herpes Varicella Zoster Kaposi’s sarcoma Lymphoma Ulcers 


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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Division of Infectious Diseases, Department of Medicine, and the William J. von Liebig Center for Transplantation and Clinical RegenerationCollege of Medicine, Mayo ClinicRochesterUSA

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