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Invasive Fungal Disease in the Transplant Population: An Overview

  • Jennifer L. SaulloEmail author
  • John R. Perfect
  • Barbara D. Alexander
Chapter

Abstract

There are numerous fungal pathogens which merit consideration in the hematopoietic cell and solid organ transplant recipients including yeasts, filamentous molds, and endemic fungi. Important differences in the incidence, types, and timeline of infections exist among the differing transplant groups. The overall risk of invasive fungal infection is affected by a multitude of factors including the transplant donor and recipient as well as transplant type. These considerations guide the implementation of prophylactic strategies and assist in targeting those at highest risk of fungal disease.

Keywords

Fungal Infections Hematopoietic Cell Transplant Solid Organ Transplant Epidemiology Aspergillus Candida Mucormycosis Cryptococcus Endemic Mycoses Fungal Prophylaxis Immunocompromised 

Abbreviations

5-FC

5-Flucytosine

5-FU

5-Fluorouracil

ABD

Amphotericin B deoxycholate

ABLC

Amphotericin B lipid complex

AML

Acute myelogenous leukemia

AST

American Society of Transplantation

CI

Cumulative incidence

CMV

Cytomegalovirus

CNI

Calcineurin inhibitor

CNS

Central nervous system

GVHD

Graft-versus-host disease

HCT

Hematopoietic cell transplant

IA

Invasive aspergillosis

IC

Invasive candidiasis

IDSA

Infectious Diseases Society of America

IFI

Invasive fungal infection

IRS

Immune reconstitution syndrome

LAMB

Liposomal amphotericin B

MDS

Myelodysplastic syndrome

MMRD

Mismatched-related donor

MRD

Matched-related donor

mTOR

Mammalian target of rapamycin

MVT

Multivisceral transplant

OHT

Orthotopic heart transplant

OLT

Orthotopic liver transplant

PATH

Prospective antifungal therapy

SBT

Small bowel transplant

SOT

Solid organ transplant

TLR

Toll-like receptor

TRANSNET

Transplant-Associated Infection Surveillance Network

URD

Unrelated donor

UTI

Urinary tract infection

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • Jennifer L. Saullo
    • 1
    Email author
  • John R. Perfect
    • 2
  • Barbara D. Alexander
    • 2
  1. 1.Duke University Medical Center, Department of Medicine, Division of Infectious Diseases and International HealthDurhamUSA
  2. 2.Duke University Medical Center, Departments of Medicine and Pathology, Division of Infectious Diseases and International HealthDurhamUSA

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