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Endovascular Infections and Endocarditis

  • Walter Zingg
  • Didier PittetEmail author
Chapter

Abstract

Acute bloodstream infection (BSI) is one of the most severe forms of infection. BSI may be primary or secondary and community-acquired or healthcare-associated. BSI is frequently observed among immunocompromised and critically ill patients, but is rarely asymptomatic and may be associated with multiple organ failure (Pittet et al. JAMA. 1994;271(20):1598–601; Edmond et al. Clin Infect Dis. 1999;29(2):239–44; Marshall et al. Crit Care Med. 2003;31(5):1560–7). Infective endocarditis (IE) is either acute or subacute, the latter being more common with underlying vascular disease.

Keywords

Infective endocarditis Bloodstream infection High-grade bacteremia Immunocompromised host Vascular disease Transplantation 

References

  1. 1.
    Pittet D, Tarara D, Wenzel RP. Nosocomial bloodstream infection in critically ill patients. Excess length of stay, extra costs, and attributable mortality. JAMA. 1994;271(20):1598–601.PubMedCrossRefGoogle Scholar
  2. 2.
    Edmond MB, Wallace SE, McClish DK, Pfaller MA, Jones RN, Wenzel RP. Nosocomial bloodstream infections in United States hospitals: a three-year analysis. Clin Infect Dis. 1999;29(2):239–44.PubMedCrossRefPubMedCentralGoogle Scholar
  3. 3.
    Marshall JC, Vincent JL, Fink MP, Cook DJ, Rubenfeld G, Foster D, et al. Measures, markers, and mediators: toward a staging system for clinical sepsis. A report of the Fifth Toronto Sepsis Roundtable, Toronto, Ontario, Canada, October 25-26, 2000. Crit Care Med. 2003;31(5):1560–7.PubMedCrossRefPubMedCentralGoogle Scholar
  4. 4.
    Brun-Buisson C, Abrouk F, Legrand P, Huet Y, Larabi S, Rapin M. Diagnosis of central venous catheter-related sepsis. Critical level of quantitative tip cultures. Arch Intern Med. 1987;147(5):873–7.PubMedCrossRefPubMedCentralGoogle Scholar
  5. 5.
    Kite P, Dobbins BM, Wilcox MH, McMahon MJ. Rapid diagnosis of central-venous-catheter-related bloodstream infection without catheter removal. Lancet. 1999;354(9189):1504–7.PubMedCrossRefPubMedCentralGoogle Scholar
  6. 6.
    Blot F, Nitenberg G, Chachaty E, Raynard B, Germann N, Antoun S, et al. Diagnosis of catheter-related bacteraemia: a prospective comparison of the time to positivity of hub-blood versus peripheral-blood cultures. Lancet. 1999;354(9184):1071–7.PubMedCrossRefPubMedCentralGoogle Scholar
  7. 7.
    Sherertz RJ, Raad II, Belani A, Koo LC, Rand KH, Pickett DL, et al. Three-year experience with sonicated vascular catheter cultures in a clinical microbiology laboratory. J Clin Microbiol. 1990;28(1):76–82.PubMedPubMedCentralGoogle Scholar
  8. 8.
    Zingg W, Eggimann P, Pittet D. Acute bloodstream infection. In: Vincent JL, Abraham E, Moore FA, Kochanek P, Fink MP, editors. Textbook of critical care. Philadelphia: Saunders; 2011. p. 1004–9.CrossRefGoogle Scholar
  9. 9.
    Li JS, Sexton DJ, Mick N, Nettles R, Fowler VG Jr, Ryan T, et al. Proposed modifications to the Duke criteria for the diagnosis of infective endocarditis. Clin Infect Dis. 2000;30(4):633–8.PubMedCrossRefPubMedCentralGoogle Scholar
  10. 10.
    Angus DC, Linde-Zwirble WT, Lidicker J, Clermont G, Carcillo J, Pinsky MR. Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care. Crit Care Med. 2001;29(7):1303–10.PubMedCrossRefGoogle Scholar
  11. 11.
    Vincent JL, Bihari DJ, Suter PM, Bruining HA, White J, Nicolas-Chanoin MH, et al. The prevalence of nosocomial infection in intensive care units in Europe. Results of the European Prevalence of Infection in Intensive Care (EPIC) study. EPIC International Advisory Committee. JAMA. 1995;274(8):639–44.PubMedCrossRefGoogle Scholar
  12. 12.
    Lyytikäinen O, Kanerva M, Agthe N, Möttönen T, Ruutu P, Finnish Prevalence Survey Study Group. Healthcare-associated infections in Finnish acute care hospitals: a national prevalence survey, 2005. J Hosp Infect. 2008;69(3):288–94.PubMedCrossRefGoogle Scholar
  13. 13.
    Vincent JL, Rello J, Marshall J, Silva E, Anzueto A, Martin CD, EPIC II Group of Investigators, et al. International study of the prevalence and outcomes of infection in intensive care units. JAMA. 2009;302(21):2323–9.CrossRefGoogle Scholar
  14. 14.
    Favre B, Hugonnet S, Correa L, Sax H, Rohner P, Pittet D. Nosocomial bacteremia: clinical significance of a single blood culture positive for coagulase-negative staphylococci. Infect Control Hosp Epidemiol. 2005;26(8):697–702.PubMedCrossRefGoogle Scholar
  15. 15.
    Hugonnet S, Sax H, Eggimann P, Chevrolet J-C, Pittet D. Nosocomial bloodstream infection and clinical sepsis. Emerg Infect Dis. 2004;10(1):76–81.PubMedPubMedCentralCrossRefGoogle Scholar
  16. 16.
    Brun-Buisson C, Doyon F, Carlet J. Bacteremia and severe sepsis in adults: a multicenter prospective survey in ICUs and wards of 24 hospitals. French Bacteremia-Sepsis Study Group. Am J Respir Crit Care Med. 1996;154(3 Pt 1):617–24.PubMedCrossRefGoogle Scholar
  17. 17.
    Renaud B, Brun-Buisson C. Outcomes of primary and catheter-related bacteremia. A cohort and case-control study in critically ill patients. Am J Respir Crit Care Med. 2001;163(7):1584–90.PubMedCrossRefGoogle Scholar
  18. 18.
    Richards MJ, Edwards JR, Culver DH, Gaynes RP. Nosocomial infections in coronary care units in the United States. National Nosocomial Infections Surveillance System. Am J Cardiol. 1998;82(6):789–93.PubMedCrossRefGoogle Scholar
  19. 19.
    Banerjee SN, Emori TG, Culver DH, Gaynes RP, Jarvis WR, Horan T, et al. Secular trends in nosocomial primary bloodstream infections in the United States, 1980–1989. National Nosocomial Infections Surveillance System. Am J Med. 1991;91(3B):86S–9S.PubMedCrossRefGoogle Scholar
  20. 20.
    Richards MJ, Edwards JR, Culver DH, Gaynes RP. Nosocomial infections in medical intensive care units in the United States. National Nosocomial Infections Surveillance System. Crit Care Med. 1999;27(5):887–92.PubMedCrossRefPubMedCentralGoogle Scholar
  21. 21.
    Richards MJ, Edwards JR, Culver DH, Gaynes RP. Nosocomial infections in pediatric intensive care units in the United States. National Nosocomial Infections Surveillance System. Pediatrics. 1999;103(4):e39.PubMedCrossRefPubMedCentralGoogle Scholar
  22. 22.
    Raymond J, Aujard Y. Nosocomial infections in pediatric patients: a European, multicenter prospective study. European Study Group. Infect Control Hosp Epidemiol. 2000;21(4):260–3.PubMedCrossRefPubMedCentralGoogle Scholar
  23. 23.
    Gastmeier P, Hentschel J, de Veer I, Obladen M, Rüden H. Device-associated nosocomial infection surveillance in neonatal intensive care using specified criteria for neonates. J Hosp Infect. 1998;38(1):51–60.PubMedCrossRefPubMedCentralGoogle Scholar
  24. 24.
    Gilio AE, Stape A, Pereira CR, Cardoso MF, Silva CV, Troster EJ. Risk factors for nosocomial infections in a critically ill pediatric population: a 25-month prospective cohort study. Infect Control Hosp Epidemiol. 2000;21(5):340–2.PubMedCrossRefPubMedCentralGoogle Scholar
  25. 25.
    Richards MJ, Edwards JR, Culver DH, Gaynes RP. Nosocomial infections in combined medical-surgical intensive care units in the United States. Infect Control Hosp Epidemiol. 2000;21(8):510–5.PubMedCrossRefPubMedCentralGoogle Scholar
  26. 26.
    Legras A, Malvy D, Quinioux AI, Villers D, Bouachour G, et al. Nosocomial infections: prospective survey of incidence in five French intensive care units. Intensive Care Med. 1998;24(10):1040–6.PubMedCrossRefPubMedCentralGoogle Scholar
  27. 27.
    Marschall J, Leone C, Jones M, Nihill D, Fraser VJ, Warren DK. Catheter-associated bloodstream infections in general medical patients outside the intensive care unit: a surveillance study. Infect Control Hosp Epidemiol. 2007;28(8):905–9.PubMedCrossRefPubMedCentralGoogle Scholar
  28. 28.
    Zingg W, Sax H, Inan C, Cartier V, Diby M, Clergue F, et al. Hospital-wide surveillance of catheter-related bloodstream infection: from the expected to the unexpected. J Hosp Infect. 2009;73(1):41–6.PubMedCrossRefPubMedCentralGoogle Scholar
  29. 29.
    Zingg W, Imhof A, Maggiorini M, Stocker R, Keller E, Ruef C. Impact of a prevention strategy targeting hand hygiene and catheter care on the incidence of catheter-related bloodstream infections. Crit Care Med. 2009;37(7):2167–73; quiz 2180.PubMedCrossRefPubMedCentralGoogle Scholar
  30. 30.
    Pittet D, Wenzel RP. Nosocomial bloodstream infections. Secular trends in rates, mortality, and contribution to total hospital deaths. Arch Intern Med. 1995;155(11):1177–84.PubMedCrossRefPubMedCentralGoogle Scholar
  31. 31.
    Vallés J, Rello J, Ochagavía A, Garnacho J, Alcalá MA. Community-acquired bloodstream infection in critically ill adult patients: impact of shock and inappropriate antibiotic therapy on survival. Chest. 2003;123(5):1615–24.PubMedCrossRefPubMedCentralGoogle Scholar
  32. 32.
    Lyytikäinen O, Lumio J, Sarkkinen H, Kolho E, Kostiala A, Ruutu P, Hospital Infection Surveillance Team. Nosocomial bloodstream infections in Finnish hospitals during 1999–2000. Clin Infect Dis. 2002;35(2):e14–9.PubMedCrossRefPubMedCentralGoogle Scholar
  33. 33.
    Valles J, Leon C, Alvarez-Lerma F. Nosocomial bacteremia in critically ill patients: a multicenter study evaluating epidemiology and prognosis. Spanish Collaborative Group for Infections in Intensive Care Units of Sociedad Espanola de Medicina Intensiva y Unidades Coronarias (SEMIUC). Clin Infect Dis. 1997;24(3):387–95.PubMedCrossRefPubMedCentralGoogle Scholar
  34. 34.
    Kollef MH, Sherman G, Ward S, Fraser VJ. Inadequate antimicrobial treatment of infections: a risk factor for hospital mortality among critically ill patients. Chest. 1999;115(2):462–74.PubMedCrossRefPubMedCentralGoogle Scholar
  35. 35.
    Elhanan G, Raz R, Pitlik SD, Sharir R, Konisberger H, Samra Z, et al. Bacteraemia in a community and a university hospital. J Antimicrob Chemother. 1995;36(4):681–95.PubMedCrossRefPubMedCentralGoogle Scholar
  36. 36.
    Eggimann P, Hugonnet S, Sax H, Touveneau S, Chevrolet JC, Pittet D. Ventilator-associated pneumonia: caveats for benchmarking. Intensive Care Med. 2003;29(11):2086–9.PubMedCrossRefPubMedCentralGoogle Scholar
  37. 37.
    Richards C, Emori TG, Edwards J, Fridkin S, Tolson J, Gaynes R. Characteristics of hospitals and infection control professionals participating in the National Nosocomial Infections Surveillance System 1999. Am J Infect Control. 2001;29(6):400–3.PubMedCrossRefPubMedCentralGoogle Scholar
  38. 38.
    Rangel-Frausto MS, Pittet D, Hwang T, Woolson RF, Wenzel RP. The dynamics of disease progression in sepsis: Markov modeling describing the natural history and the likely impact of effective antisepsis agents. Clin Infect Dis. 1998;27(1):185–90.PubMedCrossRefPubMedCentralGoogle Scholar
  39. 39.
    Connell TG, Rele M, Cowley D, Buttery JP, Curtis N. How reliable is a negative blood culture result? Volume of blood submitted for culture in routine practice in a children’s hospital. Pediatrics. 2007;119(5):891–6.PubMedCrossRefPubMedCentralGoogle Scholar
  40. 40.
    Pittet D, Li N, Woolson RF, Wenzel RP. Microbiological factors influencing the outcome of nosocomial bloodstream infections: a 6-year validated, population-based model. Clin Infect Dis. 1997;24(6):1068–78.PubMedCrossRefPubMedCentralGoogle Scholar
  41. 41.
    Siempos II, Kopterides P, Tsangaris I, Dimopoulou I, Armaganidis AE. Impact of catheter-related bloodstream infections on the mortality of critically ill patients: a meta-analysis. Crit Care Med. 2009;37(7):2283–9.PubMedCrossRefPubMedCentralGoogle Scholar
  42. 42.
    Pittet D, Thiévent B, Wenzel RP, Li N, Auckenthaler R, Suter PM. Bedside prediction of mortality from bacteremic sepsis. A dynamic analysis of ICU patients. Am J Respir Crit Care Med. 1996;153(2):684–93.PubMedCrossRefPubMedCentralGoogle Scholar
  43. 43.
    Soufir L, Timsit JF, Mahe C, Carlet J, Regnier B, Chevret S. Attributable morbidity and mortality of catheter-related septicemia in critically ill patients: a matched, risk-adjusted, cohort study. Infect Control Hosp Epidemiol. 1999;20(6):396–401.PubMedCrossRefPubMedCentralGoogle Scholar
  44. 44.
    Leibovici L, Drucker M, Konigsberger H, Samra Z, Harrari S, Ashkenazi S, Pitlik SD. Septic shock in bacteremic patients: risk factors, features and prognosis. Scand J Infect Dis. 1997;29(1):71–5.PubMedCrossRefPubMedCentralGoogle Scholar
  45. 45.
    Forgacs IC, Eykyn SJ, Bradley RD. Serious infection in the intensive therapy unit: a 15-year study of bacteraemia. Q J Med. 1986;60(232):773–9.PubMedPubMedCentralGoogle Scholar
  46. 46.
    Smith RL, Meixler SM, Simberkoff MS. Excess mortality in critically ill patients with nosocomial bloodstream infections. Chest. 1991;100(1):164–7.PubMedCrossRefPubMedCentralGoogle Scholar
  47. 47.
    Rello J, Ricart M, Mirelis B, Quintana E, Gurgui M, Net A, Prats G. Nosocomial bacteremia in a medical-surgical intensive care unit: epidemiologic characteristics and factors influencing mortality in 111 episodes. Intensive Care Med. 1994;20(2):94–8.PubMedCrossRefPubMedCentralGoogle Scholar
  48. 48.
    Pittet D, Wenzel RP. Nosocomial bloodstream infection in the critically ill. JAMA. 1994;272:1819–20.Google Scholar
  49. 49.
    Digiovine B, Chenoweth C, Watts C, Higgins M. The attributable mortality and costs of primary nosocomial bloodstream infections in the intensive care unit. Am J Respir Crit Care Med. 1999;160(3):976–81.PubMedCrossRefPubMedCentralGoogle Scholar
  50. 50.
    Rello J, Ochagavia A, Sabanes E, Roque M, Mariscal D, Reynaga E, Valles J. Evaluation of outcome of intravenous catheter-related infections in critically ill patients. Am J Respir Crit Care Med. 2000;162(3 Pt 1):1027–30.PubMedCrossRefPubMedCentralGoogle Scholar
  51. 51.
    Dimick JB, Pelz RK, Consunji R, Swoboda SM, Hendrix CW, Lipsett PA. Increased resource use associated with catheter-related bloodstream infection in the surgical intensive care unit. Arch Surg. 2001;136(2):229–34.PubMedCrossRefPubMedCentralGoogle Scholar
  52. 52.
    Laws HJ, Kobbe G, Dilloo D, Dettenkofer M, Meisel R, Geisel R, et al. Surveillance of nosocomial infections in paediatric recipients of bone marrow or peripheral blood stem cell transplantation during neutropenia, compared with adult recipients. J Hosp Infect. 2006;62(1):80–8.PubMedCrossRefPubMedCentralGoogle Scholar
  53. 53.
    Mendes ET, Dulley F, Basso M, Batista MV, Coracin F, Guimarães T, et al. Healthcare-associated infection in hematopoietic stem cell transplantation patients: risk factors and impact on outcome. Int J Infect Dis. 2012;16(6):e424–8.PubMedCrossRefPubMedCentralGoogle Scholar
  54. 54.
    Benjamin DK Jr, Miller WC, Bayliff S, Martel L, Alexander K, Martin PL. Infections diagnosed in the first year after pediatric stem cell transplantation. Pediatr Infect Dis J. 2002;21(3):227–34.PubMedPubMedCentralCrossRefGoogle Scholar
  55. 55.
    Tomonari A, Takahashi S, Ooi J, Tsukada N, Konuma T, Kobayashi T, et al. Bacterial bloodstream infection in neutropenic adult patients after myeloablative cord blood transplantation: experience of a single institution in Japan. Int J Hematol. 2007;85(3):238–41.PubMedCrossRefPubMedCentralGoogle Scholar
  56. 56.
    Wisplinghoff H, Cornely OA, Moser S, Bethe U, Stützer H, Salzberger B, et al. Outcomes of nosocomial bloodstream infections in adult neutropenic patients: a prospective cohort and matched case-control study. Infect Control Hosp Epidemiol. 2003;24(12):905–11.PubMedCrossRefPubMedCentralGoogle Scholar
  57. 57.
    Goker H, Haznedaroglu IC, Chao NJ. Acute graft-vs-host disease: pathobiology and management. Exp Hematol. 2001;29(3):259–77.PubMedCrossRefPubMedCentralGoogle Scholar
  58. 58.
    Hoen B, Alla F, Selton-Suty C, Béguinot I, Bouvet A, Briançon S, Association pour l’Etude et la Prévention de l’Endocardite Infectieuse (AEPEI) Study Group, et al. Changing profile of infective endocarditis: results of a 1-year survey in France. JAMA. 2002;288(1):75–81.PubMedCrossRefPubMedCentralGoogle Scholar
  59. 59.
    Hoen B, Chirouze C, Cabell CH, Selton-Suty C, Duchêne F, Olaison L, International Collaboration on Endocarditis Study Group, et al. Emergence of endocarditis due to group D streptococci: findings derived from the merged database of the International Collaboration on Endocarditis. Eur J Clin Microbiol Infect Dis. 2005;24(1):12–6.PubMedCrossRefPubMedCentralGoogle Scholar
  60. 60.
    Hogevik H, Olaison L, Andersson R, Lindberg J, Alestig K. Epidemiologic aspects of infective endocarditis in an urban population. A 5-year prospective study. Medicine (Baltimore). 1995;74(6):324–39.CrossRefGoogle Scholar
  61. 61.
    Berlin JA, Abrutyn E, Strom BL, Kinman JL, Levison ME, Korzeniowski OM, et al. Incidence of infective endocarditis in the Delaware Valley, 1988–1990. Am J Cardiol. 1995;76(12):933–6.PubMedCrossRefPubMedCentralGoogle Scholar
  62. 62.
    Bouza E, Menasalvas A, Muñoz P, Vasallo FJ, del Mar Moreno M, García Fernández MA. Infective endocarditis – a prospective study at the end of the twentieth century: new predisposing conditions, new etiologic agents, and still a high mortality. Medicine (Baltimore). 2001;80(5):298–307.CrossRefGoogle Scholar
  63. 63.
    van der Meer JT, Thompson J, Valkenburg HA, Michel MF. Epidemiology of bacterial endocarditis in The Netherlands. I. Patient characteristics. Arch Intern Med. 1992;152(9):1863–8.PubMedCrossRefPubMedCentralGoogle Scholar
  64. 64.
    Cabell CH, Jollis JG, Peterson GE, Corey GR, Anderson DJ, Sexton DJ, et al. Changing patient characteristics and the effect on mortality in endocarditis. Arch Intern Med. 2002;162(1):90–4.PubMedCrossRefPubMedCentralGoogle Scholar
  65. 65.
    Thuny F, Di Salvo G, Belliard O, Avierinos JF, Pergola V, Rosenberg V, et al. Risk of embolism and death in infective endocarditis: prognostic value of echocardiography: a prospective multicenter study. Circulation. 2005;112(1):69–75.PubMedCrossRefPubMedCentralGoogle Scholar
  66. 66.
    Sy RW, Kritharides L. Health care exposure and age in infective endocarditis: results of a contemporary population-based profile of 1536 patients in Australia. Eur Heart J. 2010;31(15):1890–7.PubMedCrossRefPubMedCentralGoogle Scholar
  67. 67.
    Zakrzewski T, Keith JD. Bacterial endocarditis in infants and children. J Pediatr. 1965;67:1179–93.CrossRefGoogle Scholar
  68. 68.
    Johnson DH, Rosenthal A, Nadas AS. A forty-year review of bacterial endocarditis in infancy and childhood. Circulation. 1975;51(4):581–8.PubMedCrossRefPubMedCentralGoogle Scholar
  69. 69.
    Sholler GF, Hawker RE, Celermajer JM. Infective endocarditis in childhood. Pediatr Cardiol. 1986;6(4):183–6.PubMedCrossRefPubMedCentralGoogle Scholar
  70. 70.
    Fukushige J, Igarashi H, Ueda K. Spectrum of infective endocarditis during infancy and childhood: 20-year review. Pediatr Cardiol. 1994;15(3):127–31.PubMedPubMedCentralGoogle Scholar
  71. 71.
    Tleyjeh IM, Abdel-Latif A, Rahbi H, Scott CG, Bailey KR, Steckelberg JM, et al. A systematic review of population-based studies of infective endocarditis. Chest. 2007;132(3):1025–35.PubMedCrossRefPubMedCentralGoogle Scholar
  72. 72.
    Wallace SM, Walton BI, Kharbanda RK, Hardy R, Wilson AP, Swanton RH. Mortality from infective endocarditis: clinical predictors of outcome. Heart. 2002;88(1):53–60.PubMedPubMedCentralCrossRefGoogle Scholar
  73. 73.
    Ruttmann E, Bonatti H, Legit C, Ulmer H, Stelzmueller I, Antretter H, et al. Severe endocarditis in transplant recipients – an epidemiologic study. Transpl Int. 2005;18(6):690–6.PubMedCrossRefPubMedCentralGoogle Scholar
  74. 74.
    Bishara J, Robenshtok E, Weinberger M, Yeshurun M, Sagie A, Pitlik S. Infective endocarditis in renal transplant recipients. Transpl Infect Dis. 1999;1(2):138–43.PubMedCrossRefPubMedCentralGoogle Scholar
  75. 75.
    Paterson DL, Dominguez EA, Chang FY, Snydman DR, Singh N. Infective endocarditis in solid organ transplant recipients. Clin Infect Dis. 1998;26(3):689–94.PubMedCrossRefPubMedCentralGoogle Scholar
  76. 76.
    Sherman-Weber S, Axelrod P, Suh B, Rubin S, Beltramo D, Manacchio J, et al. Infective endocarditis following orthotopic heart transplantation: 10 cases and a review of the literature. Transpl Infect Dis. 2004;6(4):165–70.PubMedPubMedCentralCrossRefGoogle Scholar
  77. 77.
    Bayer AS, Nelson RJ, Slama TG. Current concepts in prevention of prosthetic valve endocarditis. Chest. 1990;97(5):1203–7.PubMedCrossRefPubMedCentralGoogle Scholar
  78. 78.
    Steckelberg JM, Wilson WR. Risk factors for infective endocarditis. Infect Dis Clin N Am. 1993;7(1):9–19.Google Scholar
  79. 79.
    Wilson LE, Thomas DL, Astemborski J, Freedman TL, Vlahov D. Prospective study of infective endocarditis among injection drug users. J Infect Dis. 2002;185(12):1761–6.PubMedCrossRefPubMedCentralGoogle Scholar
  80. 80.
    Mathew J, Addai T, Anand A, Morrobel A, Maheshwari P, Freels S. Clinical features, site of involvement, bacteriologic findings, and outcome of infective endocarditis in intravenous drug users. Arch Intern Med. 1995;155(15):1641–8.PubMedCrossRefPubMedCentralGoogle Scholar
  81. 81.
    Gersony WM, Hayes CJ. Bacterial endocarditis in patients with pulmonary stenosis, aortic stenosis, or ventricular septal defect. Circulation. 1977;56(1 Suppl):I84–7.PubMedPubMedCentralGoogle Scholar
  82. 82.
    Raad I, Costerton W, Sabharwal U, Sacilowski M, Anaissie E, Bodey GP. Ultrastructural analysis of indwelling vascular catheters: a quantitative relationship between luminal colonization and duration of placement. J Infect Dis. 1993;168(2):400–7.PubMedCrossRefGoogle Scholar
  83. 83.
    Banin E, Brady KM, Greenberg EP. Chelator-induced dispersal and killing of Pseudomonas aeruginosa cells in a biofilm. Appl Environ Microbiol. 2006;72(3):2064–9.PubMedPubMedCentralCrossRefGoogle Scholar
  84. 84.
    Falcieri E, Vaudaux P, Huggler E, Lew D, Waldvogel F. Role of bacterial exopolymers and host factors on adherence and phagocytosis of Staphylococcus aureus in foreign body infection. J Infect Dis. 1987;155(3):524–31.PubMedCrossRefPubMedCentralGoogle Scholar
  85. 85.
    Hoffman LR, D’Argenio DA, MacCoss MJ, Zhang Z, Jones RA, Miller SI. Aminoglycoside antibiotics induce bacterial biofilm formation. Nature. 2005;436(7054):1171–5.PubMedCrossRefPubMedCentralGoogle Scholar
  86. 86.
    Mehall JR, Kite CA, Saltzman DA, Wallett T, Jackson RJ, Smith SD. Prospective study of the incidence and complications of bacterial contamination of enteral feeding in neonates. J Pediatr Surg. 2002;37(8):1177–82.PubMedCrossRefPubMedCentralGoogle Scholar
  87. 87.
    Mehall JR, Saltzman DA, Jackson RJ, Smith SD. Fibrin sheath enhances central venous catheter infection. Crit Care Med. 2002;30(4):908–12.PubMedCrossRefPubMedCentralGoogle Scholar
  88. 88.
    Qin Z, Ou Y, Yang L, Zhu Y, Tolker-Nielsen T, Molin S, Qu D. Role of autolysin-mediated DNA release in biofilm formation of Staphylococcus epidermidis. Microbiology. 2007;153(Pt 7):2083–92.PubMedCrossRefPubMedCentralGoogle Scholar
  89. 89.
    Rhodes ER, Shoemaker CJ, Menke SM, Edelmann RE, Actis LA. Evaluation of different iron sources and their influence in biofilm formation by the dental pathogen Actinobacillus actinomycetemcomitans. J Med Microbiol. 2007;56(Pt 1):119–28.PubMedCrossRefPubMedCentralGoogle Scholar
  90. 90.
    Sheth NK, Franson TR, Sohnle PG. Influence of bacterial adherence to intravascular catheters on in-vitro antibiotic susceptibility. Lancet. 1985;2(8467):1266–8.PubMedCrossRefPubMedCentralGoogle Scholar
  91. 91.
    Vaudaux P, Pittet D, Haeberli A, Lerch PG, Morgenthaler JJ, Proctor RA, et al. Fibronectin is more active than fibrin or fibrinogen in promoting Staphylococcus aureus adherence to inserted intravascular catheters. J Infect Dis. 1993;167(3):633–41.PubMedCrossRefPubMedCentralGoogle Scholar
  92. 92.
    Lin MH, Shu J-C, Huang H-Y, Chengg Y-C, Fitgerald JR, editors. Involvement of iron in biofilm formation by Staphylococcus aureus. PLoS One. 2012;7(3):e34388.Google Scholar
  93. 93.
    Moreillon P, Que YA, Bayer AS. Pathogenesis of streptococcal and staphylococcal endocarditis. Infect Dis Clin N Am. 2002;16(2):297–318.CrossRefGoogle Scholar
  94. 94.
    Greene C, McDevitt D, Francois P, Vaudaux PE, Lew DP, Foster TJ. Adhesion properties of mutants of Staphylococcus aureus defective in fibronectin-binding proteins and studies on the expression of fnb genes. Mol Microbiol. 1995;17(6):1143–52.PubMedCrossRefPubMedCentralGoogle Scholar
  95. 95.
    Darouiche RO. Device-associated infections: a macroproblem that starts with microadherence. Clin Infect Dis. 2001;33(9):1567–72.PubMedCrossRefPubMedCentralGoogle Scholar
  96. 96.
    Darouiche RO, Landon GC, Patti JM, Nguyen LL, Fernau RC, McDevitt D, et al. Role of Staphylococcus aureus surface adhesins in orthopaedic device infections: are results model-dependent? J Med Microbiol. 1997;46(1):75–9.PubMedCrossRefPubMedCentralGoogle Scholar
  97. 97.
    Schachter B. Slimy business – the biotechnology of biofilms. Nat Biotechnol. 2003;21(4):361–5.PubMedCrossRefPubMedCentralGoogle Scholar
  98. 98.
    Timsit JF, Farkas JC, Boyer JM, Martin JB, Misset B, Renaud B, Carlet J. Central vein catheter-related thrombosis in intensive care patients: incidence, risks factors, and relationship with catheter-related sepsis. Chest. 1998;114(1):207–13.PubMedCrossRefPubMedCentralGoogle Scholar
  99. 99.
    Akl EA, Vasireddi SR, Gunukula S, Yosuico VE, Barba M, Sperati F, et al. Anticoagulation for patients with cancer and central venous catheters. Cochrane Database Syst Rev. 2011;(2):CD006468.Google Scholar
  100. 100.
    Abdelkefi A, Achour W, Ben Othman T, Ladeb S, Torjman L, Lakhal A, et al. Use of heparin-coated central venous lines to prevent catheter-related bloodstream infection. J Support Oncol. 2007;5(6):273–8.PubMedPubMedCentralGoogle Scholar
  101. 101.
    Abdelkefi A, Ben Othman T, Kammoun L, Chelli M, Romdhane NB, Kriaa A, et al. Prevention of central venous line-related thrombosis by continuous infusion of low-dose unfractionated heparin, in patients with haemato-oncological disease. A randomized controlled trial. Thromb Haemost. 2004;92(3):654–61.PubMedPubMedCentralGoogle Scholar
  102. 102.
    Richet H, Hubert B, Nitemberg G, Andremont A, Buu-Hoi A, Ourbak P, et al. Prospective multicenter study of vascular-catheter-related complications and risk factors for positive central-catheter cultures in intensive care unit patients. J Clin Microbiol. 1990;28(11):2520–5.PubMedPubMedCentralGoogle Scholar
  103. 103.
    Merrer J, De Jonghe B, Golliot F, Lefrant JY, Raffy B, Barre E, French Catheter Study Group in Intensive Care, et al. Complications of femoral and subclavian venous catheterization in critically ill patients: a randomized controlled trial. JAMA. 2001;286(6):700–7.PubMedCrossRefPubMedCentralGoogle Scholar
  104. 104.
    Goetz AM, Wagener MM, Miller JM, Muder RR. Risk of infection due to central venous catheters: effect of site of placement and catheter type. Infect Control Hosp Epidemiol. 1998;19(11):842–5.PubMedCrossRefPubMedCentralGoogle Scholar
  105. 105.
    Chen HS, Wang FD, Lin M, Lin YC, Huang LJ, Liu CY. Risk factors for central venous catheter-related infections in general surgery. J Microbiol Immunol Infect. 2006;39(3):231–6.PubMedPubMedCentralGoogle Scholar
  106. 106.
    Opilla MT, Kirby DF, Edmond MB. Use of ethanol lock therapy to reduce the incidence of catheter-related bloodstream infections in home parenteral nutrition patients. JPEN J Parenter Enteral Nutr. 2007;31(4):302–5.PubMedCrossRefPubMedCentralGoogle Scholar
  107. 107.
    Zingg W, Posfay-Barbe KM, Pfister RE, Touveneau S, Pittet D. Individualized catheter surveillance among neonates: a prospective, 8-year, single-center experience. Infect Control Hosp Epidemiol. 2011;32(1):42–9.PubMedCrossRefPubMedCentralGoogle Scholar
  108. 108.
    Cobb DK, High KP, Sawyer RG, Sable CA, Adams RB, Lindley DA, et al. A controlled trial of scheduled replacement of central venous and pulmonary-artery catheters. N Engl J Med. 1992;327(15):1062–8.PubMedCrossRefPubMedCentralGoogle Scholar
  109. 109.
    Cook D, Randolph A, Kernerman P, Cupido C, King D, Soukup C, Brun-Buisson C. Central venous catheter replacement strategies: a systematic review of the literature. Crit Care Med. 1997;25(8):1417–24.CrossRefGoogle Scholar
  110. 110.
    Zurcher M, Tramer MR, Walder B. Colonization and bloodstream infection with single- versus multi-.lumen central venous catheters: a quantitative systematic review. Anesth Analg. 2004;99(1):177–82.PubMedCrossRefGoogle Scholar
  111. 111.
    Adler A, Yaniv I, Solter E, Freud E, Samra Z, Stein J, et al. Catheter-associated bloodstream infections in pediatric hematology-oncology patients: factors associated with catheter removal and recurrence. J Pediatr Hematol Oncol. 2006;28(1):23–8.PubMedGoogle Scholar
  112. 112.
    Adler A, Yaniv I, Steinberg R, Solter E, Samra Z, Stein J, Levy I. Infectious complications of implantable ports and Hickman catheters in paediatric haematology-oncology patients. J Hosp Infect. 2006;62(3):358–65.PubMedCrossRefGoogle Scholar
  113. 113.
    Bashore TM, Cabell C, Fowler V Jr. Update on infective endocarditis. Curr Probl Cardiol. 2006;31(4):274–352.PubMedCrossRefGoogle Scholar
  114. 114.
    Robard S. Blood velocity and endocarditis. Circulation. 1963;27:24.Google Scholar
  115. 115.
    Johnson CM. Adherence events in the pathogenesis of infective endocarditis. Infect Dis Clin N Am. 1993;7(1):21–36.Google Scholar
  116. 116.
    Gouriet F, Bothelo-Nevers E, Coulibaly B, Raoult D, Casalta JP. Evaluation of sedimentation rate, rheumatoid factor, C-reactive protein, and tumor necrosis factor for the diagnosis of infective endocarditis. Clin Vaccine Immunol. 2006;13(2):301.PubMedPubMedCentralCrossRefGoogle Scholar
  117. 117.
    Luzzaro F, Viganò EF, Fossati D, Grossi A, Sala A, Sturla C, Saudelli M, et al. Prevalence and drug susceptibility of pathogens causing bloodstream infections in northern Italy: a two-year study in 16 hospitals. Eur J Clin Microbiol Infect Dis. 2002;21(12):849–55.PubMedGoogle Scholar
  118. 118.
    Garden OJ, Sim AJ. A comparison of tunnelled and nontunnelled subclavian vein catheters: a prospective study of complications during parenteral feeding. Clin Nutr. 1983;2(1):51–4.PubMedCrossRefGoogle Scholar
  119. 119.
    Rosenthal VD, Maki DG, Jamulitrat S, Medeiros EA, Todi SK, Gomez DY, INICC Members, et al. International Nosocomial Infection Control Consortium (INICC) report, data summary for 2003–2008, issued June 2009. Am J Infect Control. 2010;38(2):95–104.e2.PubMedCrossRefGoogle Scholar
  120. 120.
    Macias AE, Huertas M, de Leon SP, Munoz JM, Chavez AR, Sifuentes-Osornio J, et al. Contamination of intravenous fluids: a continuing cause of hospital bacteremia. Am J Infect Control. 2010;38(3):217–21.PubMedCrossRefGoogle Scholar
  121. 121.
    Girão E, Levin AS, Basso M, Gobara S, Gomes LB, Medeiros EA, et al. Trends and outcome of 1121 nosocomial bloodstream infections in intensive care units in a Brazilian hospital, 1999–2003. Int J Infect Dis. 2008;12(6):e145–6.PubMedCrossRefGoogle Scholar
  122. 122.
    Moreno CA, Rosenthal VD, Olarte N, Gomez WV, Sussmann O, Agudelo JG, et al. Device-associated infection rate and mortality in intensive care units of 9 Colombian hospitals: findings of the International Nosocomial Infection Control Consortium. Infect Control Hosp Epidemiol. 2006;27(4):349–56.PubMedCrossRefGoogle Scholar
  123. 123.
    Agarwal R, Gupta D, Ray P, Aggarwal AN, Jindal SK. Epidemiology, risk factors and outcome of nosocomial infections in a Respiratory Intensive Care Unit in North India. J Infect. 2006;53(2):98–105.PubMedCrossRefGoogle Scholar
  124. 124.
    de Brito CS, de Brito DV, Abdallah VO, Gontijo Filho PP. Occurrence of bloodstream infection with different types of central vascular catheter in critically neonates. J Infect. 2010;60(2):128–32.PubMedCrossRefGoogle Scholar
  125. 125.
    Pawar M, Mehta Y, Kapoor P, Sharma J, Gupta A, Trehan N. Central venous catheter-related blood stream infections: incidence, risk factors, outcome, and associated pathogens. J Cardiothorac Vasc Anesth. 2004;18(3):304–8.PubMedCrossRefGoogle Scholar
  126. 126.
    Su BH, Hsieh HY, Chiu HY, Lin HC, Lin HC. Nosocomial infection in a neonatal intensive care unit: a prospective study in Taiwan. Am J Infect Control. 2007;35(3):190–5.PubMedCrossRefGoogle Scholar
  127. 127.
    Almuneef MA, Memish ZA, Balkhy HH, Hijazi O, Cunningham G, Francis C. Rate, risk factors and outcomes of catheter-related bloodstream infection in a paediatric intensive care unit in Saudi Arabia. J Hosp Infect. 2006;62(2):207–13.PubMedCrossRefGoogle Scholar
  128. 128.
    Hugonnet S, Harbarth S, Ferrière K, Ricou B, Suter P, Pittet D. Bacteremic sepsis in intensive care: temporal trends in incidence, organ dysfunction, and prognosis. Crit Care Med. 2003;31(2):390–4.PubMedCrossRefGoogle Scholar
  129. 129.
    Wisplinghoff H, Bischoff T, Tallent SM, Seifert H, Wenzel RP, Edmond MB. Nosocomial bloodstream infections in US hospitals: analysis of 24,179 cases from a prospective nationwide surveillance study. Clin Infect Dis. 2004;39(3):309–17.PubMedPubMedCentralCrossRefGoogle Scholar
  130. 130.
    Macias AE, de Leon SP, Huertas M, Maravilla E, Romero C, Montoya TG, et al. Endemic infusate contamination and related bacteremia. Am J Infect Control. 2008;36(1):48–53.PubMedCrossRefGoogle Scholar
  131. 131.
    Bizzarro MJ, Raskind C, Baltimore RS, Gallagher PG. Seventy-five years of neonatal sepsis at Yale: 1928–2003. J Hosp Infect. 2006;62(2):207–13.CrossRefGoogle Scholar
  132. 132.
    Bassetti M, Trecarichi EM, Righi E, Sanguinetti M, Bisio F, Posteraro B, et al. Incidence, risk factors, and predictors of outcome of candidemia. Survey in 2 Italian university hospitals. Diagn Microbiol Infect Dis. 2007;58(3):325–31.PubMedCrossRefGoogle Scholar
  133. 133.
    Boo TW, O’reilly B, O’leary J, Cryan B. Candidaemia in an Irish tertiary referral hospital: epidemiology and prognostic factors. Mycoses. 2005;48(4):251–9.PubMedCrossRefGoogle Scholar
  134. 134.
    Cheng YR, Lin LC, Young TG, Liu CE, Chen CH, Tsay RW. Risk factors for candidemia-related mortality at a medical center in central Taiwan. J Microbiol Immunol Infect. 2006;39(2):155–61.PubMedGoogle Scholar
  135. 135.
    Dimopoulos G, Ntziora F, Rachiotis G, Armaganidis A, Falagas ME. Candida albicans versus non-albicans intensive care unit-acquired bloodstream infections: differences in risk factors and outcome. Anesth Analg. 2008;106(2):523–9, table of contents.PubMedCrossRefGoogle Scholar
  136. 136.
    Klevay MJ, Horn DL, Neofytos D, Pfaller MA, Diekema DJ, PATH Alliance. Initial treatment and outcome of Candida glabrata versus Candida albicans bloodstream infection. Diagn Microbiol Infect Dis. 2009;64(2):152–7.PubMedCrossRefGoogle Scholar
  137. 137.
    Labelle AJ, Micek ST, Roubinian N, Kollef MH. Treatment-related risk factors for hospital mortality in Candida bloodstream infections. Crit Care Med. 2008;36(11):2967–72.PubMedCrossRefGoogle Scholar
  138. 138.
    Odds FC, Hanson MF, Davidson AD, Jacobsen MD, Wright P, Whyte JA, et al. One year prospective survey of Candida bloodstream infections in Scotland. J Med Microbiol. 2007;56(Pt 8):1066–75.PubMedPubMedCentralCrossRefGoogle Scholar
  139. 139.
    Yapar N, Uysal U, Yucesoy M, Cakir N, Yuce A. Nosocomial bloodstream infections associated with Candida species in a Turkish University Hospital. Mycoses. 2006;49(2):134–8.PubMedCrossRefGoogle Scholar
  140. 140.
    Fridkin SK, Kaufman D, Edwards JR, Shetty S, Horan T. Changing incidence of Candida bloodstream infections among NICU patients in the United States: 1995–2004. Pediatrics. 2006;117(5):1680–7.PubMedCrossRefGoogle Scholar
  141. 141.
    Labbe AC, Pepin J, Patino C, Castonguay S, Restien C, Laverdiere M. A single-centre 10-year experience with Candida bloodstream infections. Can J Infect Dis Med Microbiol. 2009;20(2):45–50.PubMedPubMedCentralCrossRefGoogle Scholar
  142. 142.
    Trick WE, Fridkin SK, Edwards JR, Hajjeh RA, Gaynes RP, National Nosocomial Infections Surveillance System Hospitals. Secular trend of hospital-acquired candidemia among intensive care unit patients in the United States during 1989–1999. Clin Infect Dis. 2002;35(5):627–30.PubMedPubMedCentralCrossRefGoogle Scholar
  143. 143.
    Lee I, Zaoutis TE, Fishman NO, Morales KH, Nachamkin I, Lautenbach E. Risk factors for fluconazole resistance in patients with Candida glabrata bloodstream infection: potential impact of control group selection on characterizing the association between previous fluconazole use and fluconazole resistance. Am J Infect Control. 2010;38(6):456–60.PubMedCrossRefGoogle Scholar
  144. 144.
    Garey KW, Rege M, Pai MP, Mingo DE, Suda KJ, Turpin RS, Bearden DT. Time to initiation of fluconazole therapy impacts mortality in patients with candidemia: a multi-institutional study. Clin Infect Dis. 2006;43(1):25–31.PubMedCrossRefGoogle Scholar
  145. 145.
    Horasan ES, Ersoz G, Tombak A, Tiftik N, Kaya A. Bloodstream infections and mortality-related factors in febrile neutropenic cancer patients. Med Sci Monit. 2011;17(5):CR304–9.PubMedPubMedCentralCrossRefGoogle Scholar
  146. 146.
    Lyytikäinen O, Ruotsalainen E, Järvinen A, Valtonen V, Ruutu P. Trends and outcome of nosocomial and community-acquired bloodstream infections due to Staphylococcus aureus in Finland, 1995–2001. Eur J Clin Microbiol Infect Dis. 2005;24(6):399–404.PubMedCrossRefGoogle Scholar
  147. 147.
    Turnidge JD, Kotsanas D, Munckhof W, Roberts S, Bennett CM, Nimmo GR, Australia New Zealand Cooperative on Outcomes in Staphylococcal Sepsis, et al. Staphylococcus aureus bacteraemia: a major cause of mortality in Australia and New Zealand. Med J Aust. 2009;191(7):368–73.PubMedGoogle Scholar
  148. 148.
    Ekkelenkamp MB, van der Bruggen T, van de Vijver DA, Wolfs TF, Bonten MJ. Bacteremic complications of intravascular catheters colonized with Staphylococcus aureus. Clin Infect Dis. 2008;46(1):114–8.PubMedCrossRefGoogle Scholar
  149. 149.
    Park KH, Kim SH, Song EH, Jang EY, Lee EJ, Chong YP, et al. Development of bacteraemia or fungaemia after removal of colonized central venous catheters in patients with negative concomitant blood cultures. Clin Microbiol Infect. 2010;16(6):742–6.PubMedCrossRefGoogle Scholar
  150. 150.
    Ruhe JJ, Menon A. Clinical significance of isolated Staphylococcus aureus central venous catheter tip cultures. Clin Microbiol Infect. 2006;12(9):933–6.PubMedCrossRefGoogle Scholar
  151. 151.
    Palmer SM, Alexander BD, Sanders LL, Edwards LJ, Reller LB, Davis RD, Tapson VF. Significance of blood stream infection after lung transplantation: analysis in 176 consecutive patients. Transplantation. 2000;69(11):2360–6.PubMedPubMedCentralCrossRefGoogle Scholar
  152. 152.
    Dettenkofer M, Ebner W, Bertz H, Babikir R, Finke J, Frank U, et al. Surveillance of nosocomial infections in adult recipients of allogeneic and autologous bone marrow and peripheral blood stem-cell transplantation. Bone Marrow Transplant. 2003;31(9):795–801.PubMedCrossRefGoogle Scholar
  153. 153.
    Danziger-Isakov LA, Sweet S, Delamorena M, Huddleston CB, Mendeloff E, Debaun MR. Epidemiology of bloodstream infections in the first year after pediatric lung transplantation. Pediatr Infect Dis J. 2005;24(4):324–30.PubMedPubMedCentralCrossRefGoogle Scholar
  154. 154.
    Dettenkofer M, Wenzler-Röttele S, Babikir R, Bertz H, Ebner W, Meyer E, Hospital Infection Surveillance System for Patients with Hematologic/Oncologic Malignancies Study Group, et al. Surveillance of nosocomial sepsis and pneumonia in patients with a bone marrow or peripheral blood stem cell transplant: a multicenter project. Clin Infect Dis. 2005;40(7):926–31.PubMedCrossRefGoogle Scholar
  155. 155.
    Ortega M, Rovira M, Almela M, Marco F, de la Bellacasa JP, Martínez JA, et al. Bacterial and fungal bloodstream isolates from 796 hematopoietic stem cell transplant recipients between 1991 and 2000. Ann Hematol. 2005;84(1):40–6.PubMedCrossRefGoogle Scholar
  156. 156.
    Rodríguez C, Muñoz P, Rodríguez-Créixems M, Yañez JF, Palomo J, Bouza E. Bloodstream infections among heart transplant recipients. Transplantation. 2006;81(3):384–91.PubMedCrossRefGoogle Scholar
  157. 157.
    Shi SH, Kong HS, Xu J, Zhang WJ, Jia CK, Wang WL, et al. Multidrug resistant gram-negative bacilli as predominant bacteremic pathogens in liver transplant recipients. Transpl Infect Dis. 2009;11(5):405–12.PubMedCrossRefGoogle Scholar
  158. 158.
    Iida T, Kaido T, Yagi S, Yoshizawa A, Hata K, Mizumoto M, et al. Posttransplant bacteremia in adult living donor liver transplant recipients. Liver Transpl. 2010;16(12):1379–85.PubMedCrossRefGoogle Scholar
  159. 159.
    Mikulska M, Del Bono V, Prinapori R, Boni L, Raiola AM, Gualandi F, et al. Risk factors for enterococcal bacteremia in allogeneic hematopoietic stem cell transplant recipients. Transpl Infect Dis. 2010;12(6):505–12.PubMedCrossRefGoogle Scholar
  160. 160.
    Hsu RB, Tsai MK, Lee PH, Le CM, Chen MF, Wang SS, et al. Bloodstream infection in heart transplant recipients: 12-year experience at a university hospital in Taiwan. Eur J Cardiothorac Surg. 2011;40(6):1362–7.PubMedPubMedCentralGoogle Scholar
  161. 161.
    Karvellas CJ, McPhail M, Pink F, Asthana S, Muiesan P, Heaton N, et al. Bloodstream infection after elective liver transplantation is associated with increased mortality in patients with cirrhosis. J Crit Care. 2011;26(5):468–74.PubMedCrossRefGoogle Scholar
  162. 162.
    Lee SO, Kang SH, Abdel-Massih RC, Brown RA, Razonable RR. Spectrum of early-onset and late-onset bacteremias after liver transplantation: implications for management. Liver Transpl. 2011;17(6):733–41.PubMedPubMedCentralCrossRefGoogle Scholar
  163. 163.
    Busca A, Cavecchia I, Locatelli F, D’Ardia S, De Rosa FG, Marmont F, et al. Blood stream infections after allogeneic stem cell transplantation: a single-center experience with the use of levofloxacin prophylaxis. Transpl Infect Dis. 2012;14(1):40–8.PubMedCrossRefPubMedCentralGoogle Scholar
  164. 164.
    van Hal SJ, Marriott DJ, Chen SC, Nguyen Q, Sorrell TC, Ellis DH, Slavin MA, Australian Candidaemia Study. Candidemia following solid organ transplantation in the era of antifungal prophylaxis: the Australian experience. Transpl Infect Dis. 2009;11(2):122–7.PubMedCrossRefGoogle Scholar
  165. 165.
    Nagy GS, Rubin RH. Disseminated Mycobacterium avium-intracellulare in a kidney transplant recipient. Transpl Infect Dis. 2001;3(4):220–30.PubMedCrossRefGoogle Scholar
  166. 166.
    Rapose A, Lick SD, Ismail N. Listeria grayi bacteremia in a heart transplant recipient. Transpl Infect Dis. 2008;10(6):434–6.PubMedCrossRefGoogle Scholar
  167. 167.
    Cerutti E, Stratta C, Romagnoli R, Serra R, Lepore M, Fop F, et al. Bacterial- and fungal-positive cultures in organ donors: clinical impact in liver transplantation. Liver Transpl. 2006;12(8):1253–9.PubMedCrossRefGoogle Scholar
  168. 168.
    Kumar D, Cattral MS, Robicsek A, Gaudreau C, Humar A. Outbreak of pseudomonas aeruginosa by multiple organ transplantation from a common donor. Transplantation. 2003;75(7):1053–5.PubMedCrossRefGoogle Scholar
  169. 169.
    Goldberg E, Bishara J, Lev S, Singer P, Cohen J. Organ transplantation from a donor colonized with a multidrug-resistant organism: a case report. Transpl Infect Dis. 2012;14(3):296–9.PubMedCrossRefGoogle Scholar
  170. 170.
    Ariza-Heredia EJ, Patel R, Blumberg EA, Walker RC, Lewis R, Evans J, et al. Outcomes of transplantation using organs from a donor infected with Klebsiella pneumoniae carbapenemase (KPC)-producing K. pneumoniae. Transpl Infect Dis. 2012;14(3):229–36.PubMedCrossRefGoogle Scholar
  171. 171.
    Martins N, Martins IS, de Freitas WV, de Matos JA, Magalhães AC, Girão VB, et al. Severe infection in a lung transplant recipient caused by donor-transmitted carbapenem-resistant Acinetobacter baumannii. Transpl Infect Dis. 2012;14(3):316–20.PubMedPubMedCentralCrossRefGoogle Scholar
  172. 172.
    Collin BA, Leather HL, Wingard JR, Ramphal R. Evolution, incidence, and susceptibility of bacterial bloodstream isolates from 519 bone marrow transplant patients. Clin Infect Dis. 2001;33(7):947–53.PubMedPubMedCentralCrossRefGoogle Scholar
  173. 173.
    Almyroudis NG, Fuller A, Jakubowski A, Sepkowitz K, Jaffe D, Small TN, et al. Pre- and post-engraftment bloodstream infection rates and associated mortality in allogeneic hematopoietic stem cell transplant recipients. Transpl Infect Dis. 2005;7(1):11–7.PubMedPubMedCentralCrossRefGoogle Scholar
  174. 174.
    Lark RL, McNeil SA, VanderHyde K, Noorani Z, Uberti J, Chenoweth C. Risk factors for anaerobic bloodstream infections in bone marrow transplant recipients. Clin Infect Dis. 2001;33(3):338–43.PubMedCrossRefGoogle Scholar
  175. 175.
    Wisplinghoff H, Seifert H, Wenzel RP, Edmond MB. Current trends in the epidemiology of nosocomial bloodstream infections in patients with hematological malignancies and solid neoplasms in hospitals in the United States. Clin Infect Dis. 2003;36(9):1103–10.CrossRefGoogle Scholar
  176. 176.
    Zinkernagel AS, Speck RF, Ruef C, Zingg W, Berger-Bachi B, Springer B. Rapidly destructive Staphylococcus epidermidis endocarditis. Infection. 2005;33(3):148–50.PubMedCrossRefPubMedCentralGoogle Scholar
  177. 177.
    Miro JM, Anguera I, Cabell CH, Chen AY, Stafford JA, Corey GR, International Collaboration on Endocarditis Merged Database Study Group, et al. Staphylococcus aureus native valve infective endocarditis: report of 566 episodes from the International Collaboration on Endocarditis Merged Database. Clin Infect Dis. 2005;41(4):507–14.PubMedCrossRefPubMedCentralGoogle Scholar
  178. 178.
    Fowler VG Jr, Sanders LL, Kong LK, McClelland RS, Gottlieb GS, Li J, et al. Infective endocarditis due to Staphylococcus aureus: 59 prospectively identified cases with follow-up. Clin Infect Dis. 1999;28(1):106–14.PubMedCrossRefPubMedCentralGoogle Scholar
  179. 179.
    Morpeth S, Murdoch D, Cabell CH, Karchmer AW, Pappas P, Levine D, International Collaboration on Endocarditis Prospective Cohort Study (ICE-PCS) Investigators, et al. Non-HACEK gram-negative bacillus endocarditis. Ann Intern Med. 2007;147(12):829–35.PubMedCrossRefPubMedCentralGoogle Scholar
  180. 180.
    Avery RK, Barnes DS, Teran JC, Wiedemann HP, Hall G, Wacker T, et al. Listeria monocytogenes tricuspid valve endocarditis with septic pulmonary emboli in a liver transplant recipient. Transpl Infect Dis. 1999;1(4):284–7.PubMedCrossRefPubMedCentralGoogle Scholar
  181. 181.
    Nasim A, Baqi S, Akhtar SF. Pseudomonas aeruginosa endocarditis in renal transplant recipients. Transpl Infect Dis. 2012;14(2):180–3.PubMedCrossRefPubMedCentralGoogle Scholar
  182. 182.
    Archuleta S, Murphy B, Keller MJ. Successful treatment of vancomycin-resistant Enterococcus faecium endocarditis with linezolid in a renal transplant recipient with human immunodeficiency virus infection. Transpl Infect Dis. 2004;6(3):117–9.PubMedCrossRefPubMedCentralGoogle Scholar
  183. 183.
    Urbina BY, Gohh R, Fischer SA. Oerskovia xanthineolytica endocarditis in a renal transplant patient: case report and review of the literature. Transpl Infect Dis. 2003;5(4):195–8.PubMedCrossRefPubMedCentralGoogle Scholar
  184. 184.
    Harlan NP, Kempker RR, Parekh SM, Burd EM, Kuhar DT. Weissella confusa bacteremia in a liver transplant patient with hepatic artery thrombosis. Transpl Infect Dis. 2011;13(3):290–3.PubMedCrossRefPubMedCentralGoogle Scholar
  185. 185.
    Philippe B, Grenet D, Honderlick P, Longchampt E, Dupont B, Picard C, Stern M. Severe Aspergillus endocarditis in a lung transplant recipient with a five-year survival. Transpl Infect Dis. 2010;12(3):273–6.PubMedCrossRefPubMedCentralGoogle Scholar
  186. 186.
    Lázaro M, Ramos A, Ussetti P, Asensio A, Laporta R, Muñez E, et al. Aspergillus endocarditis in lung transplant recipients: case report and literature review. Transpl Infect Dis. 2011;13(2):186–91.PubMedCrossRefPubMedCentralGoogle Scholar
  187. 187.
    Fournier PE, Thuny F, Richet H, Lepidi H, Casalta JP, Arzouni JP, et al. Comprehensive diagnostic strategy for blood culture-negative endocarditis: a prospective study of 819 new cases. Clin Infect Dis. 2010;51(2):131–40.PubMedCrossRefPubMedCentralGoogle Scholar
  188. 188.
    Lederman MM. Infections of the heart and vessels. In: Andreoli TE, et al., editors. Essentials of medicine. Philadelphia: W.B. Saunders; 2001.Google Scholar
  189. 189.
    Gonsalves WI, Cornish N, Moore M, Chen A, Varman M. Effects of volume and site of blood draw on blood culture results. J Clin Microbiol. 2009;47(11):3482–5.PubMedPubMedCentralCrossRefGoogle Scholar
  190. 190.
    Bouza E, Alvarado N, Alcalá L, Sánchez-Conde M, Pérez MJ, Muñoz P, et al. A prospective, randomized, and comparative study of 3 different methods for the diagnosis of intravascular catheter colonization. Clin Infect Dis. 2005;40(8):1096–100.PubMedCrossRefPubMedCentralGoogle Scholar
  191. 191.
    Maki DG, Weise CE, Sarafin HW. A semiquantitative culture method for identifying intravenous-catheter-related infection. N Engl J Med. 1977;296(23):1305–9.PubMedCrossRefPubMedCentralGoogle Scholar
  192. 192.
    Raad I, Hanna HA, Alakech B, Chatzinikolaou I, Johnson MM, Tarrand J. Differential time to positivity: a useful method for diagnosing catheter-related bloodstream infections. Ann Intern Med. 2004;140(1):18–25.PubMedCrossRefPubMedCentralGoogle Scholar
  193. 193.
    Guembe M, Rodríguez-Créixems M, Sánchez-Carrillo C, Pérez-Parra A, Martín-Rabadán P, Bouza E. How many lumens should be cultured in the conservative diagnosis of catheter-related https://www.ncbi.nlm.nih.gov/pubmed/15879906bloodstream infections? Clin Infect Dis. 2010;50(12):1575–9.PubMedCrossRefPubMedCentralGoogle Scholar
  194. 194.
    Siddiqui BK, Tariq M, Jadoon A, Alam M, Murtaza G, Abid B, et al. Impact of prior antibiotic use in culture-negative endocarditis: review of 86 cases from southern Pakistan. Int J Infect Dis. 2009;13(5):606–12.PubMedCrossRefPubMedCentralGoogle Scholar
  195. 195.
    Vandecasteele SJ, Van Eldere J, Merckx R, Peetermans WE. The effect of systemic antibiotics on the microbiological diagnosis of experimental foreign body infections caused by Staphylococcus epidermidis. Diagn Microbiol Infect Dis. 2004;48(2):89–95.PubMedCrossRefPubMedCentralGoogle Scholar
  196. 196.
    Kennedy MJ, Jackson MA, Kearns GL. Delayed diagnosis of penicillin-resistant Streptococcus mitis endocarditis following single-dose amoxicillin prophylaxis in a child. Clin Pediatr (Phila). 2004;43(8):773–6.CrossRefGoogle Scholar
  197. 197.
    Pazin GJ, Saul S, Thompson ME. Blood culture positivity: suppression by outpatient antibiotic therapy in patients with bacterial endocarditis. Arch Intern Med. 1982;142(2):263–8.PubMedPubMedCentralGoogle Scholar
  198. 198.
    Afshari A, Schrenzel J, Ieven M, Harbarth S. Bench-to-bedside review: rapid molecular diagnostics for bloodstream infection – a new frontier? Crit Care. 2012;16(3):222.PubMedPubMedCentralCrossRefGoogle Scholar
  199. 199.
    Yanagihara K, Kitagawa Y, Tomonaga M, Tsukasaki K, Kohno S, Seki M, et al. Evaluation of pathogen detection from clinical samples by real-time polymerase chain reaction using a sepsis pathogen DNA detection kit. Crit Care. 2010;14(4):R159.PubMedPubMedCentralCrossRefGoogle Scholar
  200. 200.
    Tunkel AR, Kaye D. Endocarditis with negative blood cultures. N Engl J Med. 1992;326(18):1215–7.PubMedCrossRefPubMedCentralGoogle Scholar
  201. 201.
    Nakatani S, Mitsutake K, Hozumi T, Yoshikawa J, Akiyama M, Yoshida K, Committee on Guideline for Prevention and Management of Infective Endocarditis, Japanese Circulation Society, et al. Current characteristics of infective endocarditis in Japan: an analysis of 848 cases in 2000 and 2001. Circ J. 2003;67(11):901–5.PubMedCrossRefPubMedCentralGoogle Scholar
  202. 202.
    Lamas CC, Eykyn SJ. Blood culture negative endocarditis: analysis of 63 cases presenting over 25 years. Heart. 2003;89(3):258–62.PubMedPubMedCentralCrossRefGoogle Scholar
  203. 203.
    Houpikian P, Raoult D. Blood culture-negative endocarditis in a reference center: etiologic diagnosis of 348 cases. Medicine (Baltimore). 2005;84(3):162–73.CrossRefGoogle Scholar
  204. 204.
    Raoult D, Casalta JP, Richet H, Khan M, Bernit E, Rovery C, et al. Contribution of systematic serological testing in diagnosis of infective endocarditis. J Clin Microbiol. 2005;43(10):5238–42.PubMedPubMedCentralCrossRefGoogle Scholar
  205. 205.
    Marín M, Muñoz P, Sánchez M, del Rosal M, Alcalá L, Rodríguez-Créixems M, Bouza E, Group for the Management of Infective Endocarditis of the Gregorio Marañón Hospital. Molecular diagnosis of infective endocarditis by real-time broad-range polymerase chain reaction (PCR) and sequencing directly from heart valve tissue. Medicine (Baltimore). 2007;86(4):195–202.CrossRefGoogle Scholar
  206. 206.
    Miyazato A, Ohkusu K, Tabata M, Uwabe K, Kawamura T, Tachi Y, et al. Comparative molecular and microbiological diagnosis of 19 infective endocarditis cases in which causative microbes were identified by PCR-based DNA sequencing from the excised heart valves. J Infect Chemother. 2012;18(3):318–23.PubMedCrossRefPubMedCentralGoogle Scholar
  207. 207.
    Muñoz P, Bouza E, Marín M, Alcalá L, Rodríguez Créixems M, Group for the Management of Infective Endocarditis of the Gregorio Marañón Hospital, et al. Heart valves should not be routinely cultured. J Clin Microbiol. 2008;46(9):2897–901.PubMedPubMedCentralCrossRefGoogle Scholar
  208. 208.
    Millar B, Moore J, Mallon P, Xu J, Crowe M, Mcclurg R, et al. Molecular diagnosis of infective endocarditis – a new Duke’s criterion. Scand J Infect Dis. 2001;33(9):673–80.PubMedCrossRefPubMedCentralGoogle Scholar
  209. 209.
    Bosshard PP, Kronenberg A, Zbinden R, Ruef C, Böttger EC, Altwegg M. Etiologic diagnosis of infective endocarditis by broad-range polymerase chain reaction: a 3-year experience. Clin Infect Dis. 2003;37(2):167–72.PubMedCrossRefPubMedCentralGoogle Scholar
  210. 210.
    Thuny F, Grisoli D, Collart F, Habib G, Raoult D. Management of infective endocarditis: challenges and perspectives. Lancet. 2012;379(9819):965–75.PubMedCrossRefPubMedCentralGoogle Scholar
  211. 211.
    Breitkopf C, Hammel D, Scheld HH, Peters G, Becker K. Impact of a molecular approach to improve the microbiological diagnosis of infective heart valve endocarditis. Circulation. 2005;111(11):1415–21.PubMedCrossRefPubMedCentralGoogle Scholar
  212. 212.
    Rovery C, Greub G, Lepidi H, Casalta JP, Habib G, Collart F, Raoult D. PCR detection of bacteria on cardiac valves of patients with treated bacterial endocarditis. J Clin Microbiol. 2005;43(1):163–7.PubMedPubMedCentralCrossRefGoogle Scholar
  213. 213.
    Branger S1, Casalta JP, Habib G, Collard F, Raoult D. Streptococcus pneumoniae endocarditis: persistence of DNA on heart valve material 7 years after infectious episode. J Clin Microbiol. 2003;41(9):4435–7.PubMedPubMedCentralCrossRefGoogle Scholar
  214. 214.
    Fenollar F, Raoult D. Molecular diagnosis of bloodstream infections caused by non-cultivable bacteria. Int J Antimicrob Agents. 2007;30(Suppl 1):S7–15.PubMedCrossRefGoogle Scholar
  215. 215.
    Thuny F, Habib G. When should we operate on patients with acute infective endocarditis? Heart. 2010;96(11):892–7.PubMedCrossRefGoogle Scholar
  216. 216.
    Bojalil R, Mazón-González B, Carrillo-Córdova JR, Springall R, Amezcua-Guerra LM. Frequency and clinical significance of a variety of autoantibodies in patients with definite infective endocarditis. J Clin Rheumatol. 2012;18(2):67–70.PubMedCrossRefPubMedCentralGoogle Scholar
  217. 217.
    Harbarth S, Garbino J, Pugin J, Romand JA, Lew D, Pittet D. Inappropriate initial antimicrobial therapy and its effect on survival in a clinical trial of immunomodulating therapy for severe sepsis. Am J Med. 2003;115(7):529–35.PubMedCrossRefPubMedCentralGoogle Scholar
  218. 218.
    Ibrahim EH, Sherman G, Ward S, Fraser VJ, Kollef MH. The influence of inadequate antimicrobial treatment of bloodstream infections on patient outcomes in the ICU setting. Chest. 2000;118(1):146–55.PubMedCrossRefPubMedCentralGoogle Scholar
  219. 219.
    Harbarth S, Ferrière K, Hugonnet S, Ricou B, Suter P, Pittet D. Epidemiology and prognostic determinants of bloodstream infections in surgical intensive care. Arch Surg. 2002;137(12):1353–9; discussion 1359.PubMedCrossRefPubMedCentralGoogle Scholar
  220. 220.
    Morrell M, Fraser VJ, Kollef MH. Delaying the empiric treatment of candida bloodstream infection until positive blood culture results are obtained: a potential risk factor for hospital mortality. Antimicrob Agents Chemother. 2005;49(9):3640–5.PubMedPubMedCentralCrossRefGoogle Scholar
  221. 221.
    Parkins MD, Sabuda DM, Elsayed S, Laupland KB. Adequacy of empirical antifungal therapy and effect on outcome among patients with invasive Candida species infections. J Antimicrob Chemother. 2007;60(3):613–8.PubMedCrossRefPubMedCentralGoogle Scholar
  222. 222.
    Bouadma L, Luyt CE, Tubach F, Cracco C, Alvarez A, Schwebel C, et al. Use of procalcitonin to reduce patients’ exposure to antibiotics in intensive care units (PRORATA trial): a multicentre randomised controlled trial. Lancet. 2010;375(9713):463–74.PubMedCrossRefPubMedCentralGoogle Scholar
  223. 223.
    Harbarth S, Albrich WC, Muller B. When once is not enough – further evidence of procalcitonin-guided antibiotic stewardship. Crit Care. 2009;13(4):165.PubMedPubMedCentralCrossRefGoogle Scholar
  224. 224.
    Nobre V, Harbarth S, Graf JD, Rohner P, Pugin J. Use of procalcitonin to shorten antibiotic treatment duration in septic patients: a randomized trial. Am J Respir Crit Care Med. 2008;177(5):498–505.PubMedCrossRefPubMedCentralGoogle Scholar
  225. 225.
    Fernandez-Hidalgo N, Almirante B, Calleja R, Ruiz I, Planes AM, Rodriguez D, et al. Antibiotic-lock therapy for long-term intravascular catheter-related bacteraemia: results of an open, non-comparative study. J Antimicrob Chemother. 2006;57(6):1172–80.PubMedCrossRefPubMedCentralGoogle Scholar
  226. 226.
    Fortún J, Grill F, Martín-Dávila P, Blázquez J, Tato M, Sánchez-Corral J, et al. Treatment of long-term intravascular catheter-related bacteraemia with antibiotic-lock therapy. J Antimicrob Chemother. 2006;58(4):816–21.PubMedCrossRefPubMedCentralGoogle Scholar
  227. 227.
    Mermel LA, Allon M, Bouza E, Craven DE, Flynn P, O’Grady NP, et al. Clinical practice guidelines for the diagnosis and management of intravascular catheter-related infection: 2009 update by the Infectious Diseases Society of America. Clin Infect Dis. 2009;49(1):1–45.PubMedPubMedCentralCrossRefGoogle Scholar
  228. 228.
    Maki DG, et al. Hospital infections. 4th ed. Philadelphia: Lippincott-Raven; 1998.Google Scholar
  229. 229.
    Rosen AB, Fowler VG Jr, Corey GR, Downs SM, Biddle AK, Li J, Jollis JG. Cost-effectiveness of transesophageal echocardiography to determine the duration of therapy for intravascular catheter-associated Staphylococcus aureus bacteremia. Ann Intern Med. 1999;130(10):810–20.PubMedCrossRefPubMedCentralGoogle Scholar
  230. 230.
    Baddour LM, Wilson WR, Bayer AS, Fowler VG Jr, Bolger AF, Levison ME, Committee on Rheumatic Fever, Endocarditis, and Kawasaki Disease, Council on Cardiovascular Disease in the Young, Councils on Clinical Cardiology, Stroke, and Cardiovascular Surgery and Anesthesia, American Heart Association, Infectious Diseases Society of America, et al. Infective endocarditis: diagnosis, antimicrobial therapy, and management of complications: a statement for healthcare professionals from the Committee on Rheumatic Fever, Endocarditis, and Kawasaki Disease, Council on Cardiovascular Disease in the Young, and the Councils on Clinical Cardiology, Stroke, and Cardiovascular Surgery and Anesthesia, American Heart Association: endorsed by the Infectious Diseases Society of America. Circulation. 2005;111(23):e394–434.PubMedGoogle Scholar
  231. 231.
    Habib G, Hoen B, Tornos P, Thuny F, Prendergast B, Vilacosta I, ESC Committee for Practice Guidelines, et al. Guidelines on the prevention, diagnosis, and treatment of infective endocarditis (new version 2009): the Task Force on the Prevention, Diagnosis, and Treatment of Infective Endocarditis of the European Society of Cardiology (ESC). Endorsed by the European Society of Clinical Microbiology and Infectious Diseases (ESCMID) and the International Society of Chemotherapy (ISC) for Infection and Cancer. Eur Heart J. 2009;30(19):2369–413.PubMedCrossRefGoogle Scholar
  232. 232.
    Ribera E, Gómez-Jimenez J, Cortes E, del Valle O, Planes A, Gonzalez-Alujas T, et al. Effectiveness of cloxacillin with and without gentamicin in short-term therapy for right-sided Staphylococcus aureus endocarditis. A randomized, controlled trial. Ann Intern Med. 1996;125(12):969–74.PubMedCrossRefGoogle Scholar
  233. 233.
    Korzeniowski O, Sande MA. Combination antimicrobial therapy for Staphylococcus aureus endocarditis in patients addicted to parenteral drugs and in nonaddicts: a prospective study. Ann Intern Med. 1982;97(4):496–503.PubMedCrossRefGoogle Scholar
  234. 234.
    Abrams B, Sklaver A, Hoffman T, Greenman R. Single or combination therapy of staphylococcal endocarditis in intravenous drug abusers. Ann Intern Med. 1979;90(5):789–91.PubMedCrossRefGoogle Scholar
  235. 235.
    Coppens L, Hanson B, Klastersky J. Therapy of staphylococcal infections with cefamandole or vancomycin alone or with a combination of cefamandole and tobramycin. Antimicrob Agents Chemother. 1983;23(1):36–41.PubMedPubMedCentralCrossRefGoogle Scholar
  236. 236.
    Birmingham MC, Rayner CR, Meagher AK, Flavin SM, Batts DH, Schentag JJ. Linezolid for the treatment of multidrug-resistant, gram-positive infections: experience from a compassionate-use program. Clin Infect Dis. 2003;36(2):159–68.PubMedCrossRefGoogle Scholar
  237. 237.
    Fowler VG Jr, Boucher HW, Corey GR, Abrutyn E, Karchmer AW, Rupp ME, S. aureus Endocarditis and Bacteremia Study Group, et al. Daptomycin versus standard therapy for bacteremia and endocarditis caused by Staphylococcus aureus. N Engl J Med. 2006;355(7):653–65.PubMedCrossRefGoogle Scholar
  238. 238.
    Lodise TP, McKinnon PS, Swiderski L, Rybak MJ. Outcomes analysis of delayed antibiotic treatment for hospital-acquired Staphylococcus aureus bacteremia. Clin Infect Dis. 2003;36(11):1418–23.PubMedCrossRefGoogle Scholar
  239. 239.
    Fernández-Hidalgo N, Almirante B, Tornos P, González-Alujas MT, Planes AM, Larrosa MN, et al. Prognosis of left-sided infective endocarditis in patients transferred to a tertiary-care hospital – prospective analysis of referral bias and influence of inadequate antimicrobial treatment. Clin Microbiol Infect. 2011;17(5):769–75.PubMedCrossRefGoogle Scholar
  240. 240.
    Dickerman SA, Abrutyn E, Barsic B, Bouza E, Cecchi E, Moreno A, ICE Investigators, et al. The relationship between the initiation of antimicrobial therapy and the incidence of stroke in infective endocarditis: an analysis from the ICE Prospective Cohort Study (ICE-PCS). Am Heart J. 2007;154(6):1086–94.PubMedPubMedCentralCrossRefGoogle Scholar
  241. 241.
    Shapira N, Merin O, Rosenmann E, Dzigivker I, Bitran D, Yinnon AM, Silberman S. Latent infective endocarditis: epidemiology and clinical characteristics of patients with unsuspected endocarditis detected after elective valve replacement. Ann Thorac Surg. 2004;78(5):1623–9.PubMedCrossRefGoogle Scholar
  242. 242.
    Bannay A, Hoen B, Duval X, Obadia JF, Selton-Suty C, Le Moing V, AEPEI Study Group, et al. The impact of valve surgery on short- and long-term mortality in left-sided infective endocarditis: do differences in methodological approaches explain previous conflicting results? Eur Heart J. 2011;32(16):2003–15.PubMedCrossRefGoogle Scholar
  243. 243.
    Lalani T, Cabell CH, Benjamin DK, Lasca O, Naber C, Fowler VG, International Collaboration on Endocarditis-Prospective Cohort Study (ICE-PCS) Investigators, et al. Analysis of the impact of early surgery on in-hospital mortality of native valve endocarditis: use of propensity score and instrumental variable methods to adjust for treatment-selection bias. Circulation. 2010;121(8):1005–13.PubMedPubMedCentralCrossRefGoogle Scholar
  244. 244.
    Delahaye F, Rial MO, de Gevigney G, Ecochard R, Delaye J. A critical appraisal of the quality of the management of infective endocarditis. J Am Coll Cardiol. 1999;33(3):788–93.PubMedCrossRefGoogle Scholar
  245. 245.
    Botelho-Nevers E, Thuny F, Casalta JP, Richet H, Gouriet F, Collart F, et al. Dramatic reduction in infective endocarditis-related mortality with a management-based approach. Arch Intern Med. 2009;169(14):1290–8.PubMedCrossRefGoogle Scholar
  246. 246.
    Thuny F, Fournier PE, Casalta JP, Gouriet F, Lepidi H, Riberi A, et al. Investigation of blood culture-negative early prosthetic valve endocarditis reveals high prevalence of fungi. Heart. 2010;96(10):743–7.PubMedCrossRefGoogle Scholar
  247. 247.
    Pittet D, Hugonnet S, Harbarth S, Mourouga P, Sauvan V, Touveneau S, Perneger TV. Effectiveness of a hospital-wide programme to improve compliance with hand hygiene. Infection Control Programme. Lancet. 2000;356(9238):1307–12.CrossRefGoogle Scholar
  248. 248.
    Hugonnet S, Perneger TV, Pittet D. Alcohol-based handrub improves compliance with hand hygiene in intensive care units. Arch Intern Med. 2002;162(9):1037–43.PubMedCrossRefGoogle Scholar
  249. 249.
    World Health Organization. WHO guidelines for hand hygiene in health care. Geneva: World Health Organization; 2009.Google Scholar
  250. 250.
    Pessoa-Silva CL, Hugonnet S, Pfister R, Touveneau S, Dharan S, Posfay-Barbe K, Pittet D. Reduction of health care associated infection risk in neonates by successful hand hygiene promotion. Pediatrics. 2007;120(2):e382–90.CrossRefGoogle Scholar
  251. 251.
    Eggimann P, Harbarth S, Constantin MN, Touveneau S, Chevrolet JC, Pittet D. Impact of a prevention strategy targeted at vascular-access care on incidence of infections acquired in intensive care. Lancet. 2000;355(9218):1864–8.PubMedCrossRefGoogle Scholar
  252. 252.
    Eggimann P, Hugonnet S, Sax H, Harbarth S, Chevrolet JC, Pittet D. Long-term reduction of vascular access-associated bloodstream infection. Ann Intern Med. 2005;142(10):875–6.PubMedCrossRefGoogle Scholar
  253. 253.
    Pronovost P, Needham D, Berenholtz S, Sinopoli D, Chu H, Cosgrove S, et al. An intervention to decrease catheter-related bloodstream infections in the ICU. N Engl J Med. 2006;355(26):2725–32.PubMedCrossRefGoogle Scholar
  254. 254.
    Pronovost PJ, Goeschel CA, Colantuoni E, Watson S, Lubornski LH, Berehnnholtz SM, et al. Sustaining reductions in catheter related bloodstream infections in Michigan intensive care units: observational study. BMJ. 2010;340:c309.PubMedPubMedCentralCrossRefGoogle Scholar
  255. 255.
    Timsit JF, Schwebel C, Bouadma L, Geffroy A, Garrouste-Orgeas M, Pease S, Dressing Study Group, et al. Chlorhexidine-impregnated sponges and less frequent dressing changes for prevention of catheter-related infections in critically ill adults: a randomized controlled trial. JAMA. 2009;301(12):1231–41.PubMedCrossRefGoogle Scholar
  256. 256.
    Ruschulte H, Franke M, Gastmeier P, Zenz S, Mahr KH, Buchholz S, et al. Prevention of central venous catheter related infections with chlorhexidine gluconate impregnated wound dressings: a randomized controlled trial. Ann Hematol. 2009;88(3):267–72.PubMedCrossRefGoogle Scholar
  257. 257.
    Climo MW, Sepkowitz KA, Zuccotti G, Fraser VJ, Warren DK, Perl TM, et al. The effect of daily bathing with chlorhexidine on the acquisition of methicillin-resistant Staphylococcus aureus, vancomycin-resistant Enterococcus, and healthcare-associated bloodstream infections: results of a quasi-experimental multicenter trial. Crit Care Med. 2009;37(6):1858–65.PubMedCrossRefGoogle Scholar
  258. 258.
    Niel-Weise BS, Stijnen T, van den Broek PJ. Anti-infective-treated central venous catheters for total parenteral nutrition or chemotherapy: a systematic review. J Hosp Infect. 2008;69(2):114–23.PubMedCrossRefGoogle Scholar
  259. 259.
    Ramritu P, Halton K, Collignon P, Cook D, Fraenkel D, Battistutta D, et al. A systematic review comparing the relative effectiveness of antimicrobial-coated catheters in intensive care units. Am J Infect Control. 2008;36(2):104–17.PubMedCrossRefGoogle Scholar
  260. 260.
    Walder B, Pittet D, Tramer MR. Prevention of bloodstream infections with central venous catheters treated with anti-infective agents depends on catheter type and insertion time: evidence from a meta-analysis. Infect Control Hosp Epidemiol. 2002;23(12):748–56.PubMedCrossRefGoogle Scholar
  261. 261.
    Maki DG, Ash SR, Winger RK, Lavin P, AZEPTIC Trial Investigators. A novel antimicrobial and antithrombotic lock solution for hemodialysis catheters: a multi-center, controlled, randomized trial. Crit Care Med. 2011;39(4):613–20.PubMedCrossRefGoogle Scholar
  262. 262.
    Raad II, Fang X, Keutgen XM, Jiang Y, Sherertz R, Hachem R. The role of chelators in preventing biofilm formation and catheter-related bloodstream infections. Curr Opin Infect Dis. 2008;21(4):385–92.PubMedCrossRefGoogle Scholar
  263. 263.
    Ferreira Chacon JM, Hato de Almeida E, de Lourdes Simões R, Lazzarin C Ozório V, Alves BC, Mello de Andréa ML, et al. Randomized study of minocycline and edetic acid as a locking solution for central line (port-a-cath) in children with cancer. Chemotherapy. 2011;57(4):285–91.PubMedCrossRefGoogle Scholar
  264. 264.
    Dümichen MJ, Seeger K, Lode HN, Kühl JS, Ebell W, Degenhardt P, et al. Randomized controlled trial of taurolidine citrate versus heparin as catheter lock solution in paediatric patients with haematological malignancies. J Hosp Infect. 2012;80(4):304–9.PubMedCrossRefGoogle Scholar
  265. 265.
    Sherertz RJ, Boger MS, Collins CA, Mason L, Raad II. Comparative in vitro efficacies of various catheter lock solutions. Antimicrob Agents Chemother. 2006;50(5):1865–8.PubMedPubMedCentralCrossRefGoogle Scholar
  266. 266.
    Takla TA, Zelenitsky SA, Vercaigne LM. Effectiveness of a 30% ethanol/4% trisodium citrate locking solution in preventing biofilm formation by organisms causing haemodialysis catheter-related infections. J Antimicrob Chemother. 2008;62(5):1024–6.PubMedCrossRefGoogle Scholar
  267. 267.
    Cober MP, Kovacevich DS, Teitelbaum DH. Ethanol-lock therapy for the prevention of central venous access device infections in pediatric patients with intestinal failure. JPEN J Parenter Enteral Nutr. 2010;35(1):67–73.PubMedCrossRefGoogle Scholar
  268. 268.
    Jones BA, Hull MA, Richardson DS, Zurakowski D, Gura K, Fitzgibbons SC, et al. Efficacy of ethanol locks in reducing central venous catheter infections in pediatric patients with intestinal failure. J Pediatr Surg. 2010;45(6):1287–93.PubMedPubMedCentralCrossRefGoogle Scholar
  269. 269.
    Oliveira C, Nasr A, Brindle M, Wales PW. Ethanol locks to prevent catheter-related bloodstream infections in parenteral nutrition: a meta-analysis. Pediatrics. 2012;129(2):318–29.PubMedCrossRefGoogle Scholar
  270. 270.
    Crnich CJ, Duster M, Jones A, Maki DG. Prospective randomized double-blind trial of an ethanol lock for prevention of CLABSI. In: 49th Interscience Conference on Antimicrobial Agents and Chemotherapy [Abstract]. San Francisco; 2009Google Scholar
  271. 271.
    Slobbe L, Doorduijn JK, Lugtenburg PJ, El Barzouhi A, Boersma E, van Leeuwen WB, Rijnders BJ. Prevention of catheter-related bacteremia with a daily ethanol lock in patients with tunnelled catheters: a randomized, placebo-controlled trial. PLoS One. 2010;5(5):e10840.PubMedPubMedCentralCrossRefGoogle Scholar
  272. 272.
    Perez MJ, et al. Ethanol lock therapy in the prevention of catheter-related bloodstream infections after major heart surgery. In: 22nd European Congress of Clinical Microbiology and Infectious Diseases [Abstract]: London; 2012. p. P1355.Google Scholar
  273. 273.
    DePalo VA, McNicoll L, Cornell M, Rocha JM, Adams L, Pronovost PJ. The Rhode Island ICU collaborative: a model for reducing central line-associated bloodstream infection and ventilator-associated pneumonia statewide. Qual Saf Health Care. 2010;19(6):555–61.PubMedGoogle Scholar
  274. 274.
    Marra AR, Cal RG, Durão MS, Correa L, Guastelli LR, Moura DF Jr, et al. Impact of a program to prevent central line-associated bloodstream infection in the zero tolerance era. Am J Infect Control. 2010;38(6):434–9.PubMedCrossRefGoogle Scholar
  275. 275.
    Miller MR, Griswold M, Harris JM 2nd, Yenokyan G, Huskins WC, Moss M, et al. Decreasing PICU catheter-associated bloodstream infections: NACHRI’s quality transformation efforts. Pediatrics. 2010;125(2):206–13.PubMedCrossRefGoogle Scholar
  276. 276.
    Peredo R, Sabatier C, Villagra A, Gonzalez J, Hernandez C, Perez F, et al. Reduction in catheter-related bloodstream infections in critically ill patients through a multiple system intervention. Eur J Clin Microbiol Infect Dis. 2010;29(9):1173–7.PubMedCrossRefGoogle Scholar
  277. 277.
    Pérez Parra A, Cruz Menárguez M, Pérez Granda MJ, Tomey MJ, et al. A simple educational intervention to decrease incidence of central line-associated bloodstream infection (CLABSI) in intensive care units with low baseline incidence of CLABSI. Infect Control Hosp Epidemiol. 2010;31(9):964–7.PubMedCrossRefGoogle Scholar
  278. 278.
    Britt RC, Novosel TJ, Britt LD, Sullivan M. The impact of central line simulation before the ICU experience. Am J Surg. 2009;197(4):533–6.PubMedCrossRefGoogle Scholar
  279. 279.
    Barsuk JH, Cohen ER, Feinglass J, McGaghie WC, Wayne DB. Use of simulation-based education to reduce catheter-related bloodstream infections. Arch Intern Med. 2009;169(15):1420–3.PubMedCrossRefGoogle Scholar
  280. 280.
    Barsuk JH, Cohen ER, McGaghie WC, Wayne DB. Long-term retention of central venous catheter insertion skills after simulation-based mastery learning. Acad Med. 2010;85(10 Suppl):S9–12.PubMedCrossRefGoogle Scholar
  281. 281.
    Barsuk JH, McGaghie WC, Cohen ER, O’Leary KJ, Wayne DB. Simulation-based mastery learning reduces complications during central venous catheter insertion in a medical intensive care unit. Crit Care Med. 2009;37(10):2697–701.PubMedGoogle Scholar
  282. 282.
    Khouli H, Jahnes K, Shapiro J, Rose K, Mathew J, Gohil A, et al. Performance of medical residents in sterile techniques during central vein catheterization: randomized trial of efficacy of simulation-based training. Chest. 2011;139(1):80–7.PubMedCrossRefGoogle Scholar
  283. 283.
    Sherertz RJ, Ely EW, Westbrook DM, Gledhill KS, Streed SA, Kiger B, et al. Education of physicians-in-training can decrease the risk for vascular catheter infection. Ann Intern Med. 2000;132(8):641–8.PubMedCrossRefPubMedCentralGoogle Scholar
  284. 284.
    Larson EL, Quiros D, Lin SX. Dissemination of the CDC’s Hand Hygiene Guideline and impact on infection rates. Am J Infect Control. 2007;35(10):666–75.PubMedPubMedCentralCrossRefGoogle Scholar
  285. 285.
    Hall G, Hedström SA, Heimdahl A, Nord CE. Prophylactic administration of penicillins for endocarditis does not reduce the incidence of postextraction bacteremia. Clin Infect Dis. 1993;17(2):188–94.PubMedCrossRefGoogle Scholar
  286. 286.
    Lockhart PB, Brennan MT, Sasser HC, Fox PC, Paster BJ, Bahrani-Mougeot FK. Bacteremia associated with toothbrushing and dental extraction. Circulation. 2008;117(24):3118–25.PubMedPubMedCentralCrossRefGoogle Scholar
  287. 287.
    Lacassin F, Hoen B, Leport C, Selton-Suty C, Delahaye F, Goulet V, et al. Procedures associated with infective endocarditis in adults. A case control study. Eur Heart J. 1995;16(12):1968–74.PubMedCrossRefGoogle Scholar
  288. 288.
    Strom BL, Abrutyn E, Berlin JA, Kinman JL, Feldman RS, Stolley PD, et al. Risk factors for infective endocarditis: oral hygiene and nondental exposures. Circulation. 2000;102(23):2842–8.PubMedCrossRefGoogle Scholar
  289. 289.
    Pallasch TJ. Antibiotic prophylaxis: problems in paradise. Dent Clin N Am. 2003;47(4):665–79.PubMedCrossRefGoogle Scholar
  290. 290.
    Wilson W, Taubert KA, Gewitz M, Lockhart PB, Baddour LM, Levison M, American Heart Association Rheumatic Fever, Endocarditis, and Kawasaki Disease Committee, American Heart Association Council on Cardiovascular Disease in the Young, American Heart Association Council on Clinical Cardiology, American Heart Association Council on Cardiovascular Surgery and Anesthesia, Quality of Care and Outcomes Research Interdisciplinary Working Group, et al. Prevention of infective endocarditis: guidelines from the American Heart Association: a guideline from the American Heart Association Rheumatic Fever, Endocarditis, and Kawasaki Disease Committee, Council on Cardiovascular Disease in the Young, and the Council on Clinical Cardiology, Council on Cardiovascular Surgery and Anesthesia, and the Quality of Care and Outcomes Research Interdisciplinary Working Group. Circulation. 2007;116(15):1736–54.PubMedCrossRefGoogle Scholar
  291. 291.
    Prophylaxis against infective endocarditis: antimicrobial prophylaxis against infective endocarditis in adults and children undergoing interventional procedures [Internet]. 2008.Google Scholar
  292. 292.
    da Silva DB, Souza IP, Cunha MC. Knowledge, attitudes and status of oral health in children at risk for infective endocarditis. Int J Paediatr Dent. 2002;12(2):124–31.PubMedCrossRefGoogle Scholar
  293. 293.
    Duva X, Leport C. Prophylaxis of infective endocarditis: current tendencies, continuing controversies. Lancet Infect Dis. 2008;8(4):225–32.CrossRefGoogle Scholar
  294. 294.
    Forner L, Larsen T, Kilian M, Holmstrup P. Incidence of bacteremia after chewing, tooth brushing and scaling in individuals with periodontal inflammation. J Clin Periodontol. 2006;33(6):401–7.PubMedCrossRefGoogle Scholar
  295. 295.
    Roberts GJ. Dentists are innocent! “Everyday” bacteremia is the real culprit: a review and assessment of the evidence that dental surgical procedures are a principal cause of bacterial endocarditis in children. Pediatr Cardiol. 1999;20(5):317–25.PubMedCrossRefGoogle Scholar

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© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Infection Control Programme and WHO Collaborating Centre on Patient Safety, University of Geneva Hospitals and Faculty of MedicineGenevaSwitzerland

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