Advertisement

Adipocytic Tumors

  • Steven D. BillingsEmail author
  • Rajiv M. Patel
Chapter

Abstract

Adipocytic tumors are commonly encountered in dermatopathology. Most are variants of lipomas, but rare cutaneous liposarcomas do occur. This chapter will cover the range of adipocytic tumors encountered in dermatopathology and discuss challenging variants and their differential diagnoses.

Keywords

Lipoma Angiolipoma Spindle cell lipoma Pleomorphic lipoma Chondroid lipoma Lipoblastoma Hibernoma Pleomorphic liposarcoma Atypical lipomatous tumor Dedifferentiated liposarcoma Myxoid liposarcoma 

Selected References

  1. 1.
    Billings SD, Folpe AL. Diagnostically challenging spindle cell lipomas: a report of 34 “low-fat” and “fat-free” variants. Am J Dermatopathol. 2007;29(5):437–42.CrossRefGoogle Scholar
  2. 2.
    Buehler D, Marburger TB, Billings SD. Primary subcutaneous myxoid liposarcoma: a clinicopathologic review of three cases with molecular confirmation and discussion of the differential diagnosis. J Cutan Pathol. 2014;41(12):907–15.CrossRefGoogle Scholar
  3. 3.
    Byun JY, Choi YW, Choi HY, Myung KB. A case of dedifferentiated Liposarcoma that developed in the dermis. Ann Dermatol. 2008;20(4):204–8.CrossRefGoogle Scholar
  4. 4.
    Carvalho GS, Cavalcanti SM, Herênio AS, Teixeira MA, Alencar ER, Gonçalves SP. Nevus lipomatosus cutaneous superficialis. An Bras Dermatol. 2016;91(5 suppl 1):114–5.CrossRefGoogle Scholar
  5. 5.
    Chen BJ, Mariño-Enríquez A, Fletcher CD, Hornick JL. Loss of retinoblastoma protein expression in spindle cell/pleomorphic lipomas and cytogenetically related tumors: an immunohistochemical study with diagnostic implications. Am J Surg Pathol. 2012;36(8):1119–28.CrossRefGoogle Scholar
  6. 6.
    Coffin CM. Lipoblastoma: an embryonal tumor of soft tissue related to organogenesis. Semin Diagn Pathol. 1994;11(2):98–103.PubMedGoogle Scholar
  7. 7.
    Collins MH, Chatten J. Lipoblastoma/lipoblastomatosis: a clinicopathologic study of 25 tumors. Am J Surg Pathol. 1997;21(10):1131–7.CrossRefGoogle Scholar
  8. 8.
    Dadone B, Refae S, Lemarié-Delaunay C, Bianchini L, Pedeutour F. Molecular cytogenetics of pediatric adipocytic tumors. Cancer Genet. 2015;208(10):469–81.CrossRefGoogle Scholar
  9. 9.
    Dei Tos AP, Mentzel T, Fletcher CD. Primary liposarcoma of the skin: a rare neoplasm with unusual high grade features. Am J Dermatopathol. 1998;20(4):332–8.CrossRefGoogle Scholar
  10. 10.
    Enzinger FM, Harvey DA. Spindle cell lipoma. Cancer. 1975;36(5):1852–9.CrossRefGoogle Scholar
  11. 11.
    Evans HL. Atypical lipomatous tumor, its variants, and its combined forms: a study of 61 cases, with a minimum follow-up of 10 years. Am J Surg Pathol. 2007;31(1):1–14.CrossRefGoogle Scholar
  12. 12.
    Furlong MA, Fanburg-Smith JC, Miettinen M. The morphologic spectrum of hibernoma: a clinicopathologic study of 170 cases. Am J Surg Pathol. 2001;25(6):809–14.CrossRefGoogle Scholar
  13. 13.
    Gardner JM, Dandekar M, Thomas D, Goldblum JR, Weiss SW, Billings SD, Lucas DR, McHugh JB, Patel RM. Cutaneous and subcutaneous pleomorphic liposarcoma: a clinicopathologic study of 29 cases with evaluation of MDM2 gene amplification in 26. Am J Surg Pathol. 2012;36(7):1047–51.CrossRefGoogle Scholar
  14. 14.
    Hofvander J, Arbajian E, Stenkula KG, Lindkvist-Petersson K, Larsson M, Nilsson J, Magnusson L, von Steyern FV, Rissler P, Hornick JL, Mertens F. Frequent low-level mutations of protein kinase D2 in angiolipoma. J Pathol. 2017;241(5):578–82.CrossRefGoogle Scholar
  15. 15.
    Ko JS, Daniels B, Emanuel PO, Elson P, Khachaturov V, McKenney JK, Goldblum JR, Billings SD. Spindle cell lipomas in women: a report of 53 cases. Am J Surg Pathol. 2017;41(9):1267–74.CrossRefGoogle Scholar
  16. 16.
    Mehregan AH, Tavafoghi V, Ghandchi A. Nevus lipomatosus cutaneous superficialis (Hoffmann-Zurhelle). J Cutan Pathol. 1975;2(6):307–13.CrossRefGoogle Scholar
  17. 17.
    Meis JM, Enzinger FM. Chondroid lipoma. A unique tumor simulating liposarcoma and myxoid chondrosarcoma. Am J Surg Pathol. 1993;17(11):1103–12.CrossRefGoogle Scholar
  18. 18.
    Paredes BE, Mentzel T. Atypical lipomatous tumor/“well-differentiated liposarcoma” of the skin clinically presenting as a skin tag: clinicopathologic, immunohistochemical, and molecular analysis of 2 cases. Am J Dermatopathol. 2011;33(6):603–7.CrossRefGoogle Scholar
  19. 19.
    Roh HS, Lee HE, Park MH, Ko JY, Ro YS. Subcutaneous myxoid and round cell liposarcoma. Ann Dermatol. 2011;23(3):338–41.CrossRefGoogle Scholar
  20. 20.
    Sheng W, Lu L, Wang J. Cellular angiolipoma: a clinicopathological and immunohistochemical study of 12 cases. Am J Dermatopathol. 2013;35(2):220–5.CrossRefGoogle Scholar
  21. 21.
    Shmookler BM, Enzinger FM. Pleomorphic lipoma: a benign tumor simulating liposarcoma. A clinicopathologic analysis of 48 cases. Cancer. 1981;47(1):126–33.CrossRefGoogle Scholar
  22. 22.
    Thomson TA, Horsman D, Bainbridge TC. Cytogenetic and cytologic features of chondroid lipoma of soft tissue. Mod Pathol. 1999;12(1):88–91.PubMedGoogle Scholar
  23. 23.
    Thway K, Flora RS, Fisher C. Chondroid lipoma: an update and review. Ann Diagn Pathol. 2012;16(3):230–4.CrossRefGoogle Scholar
  24. 24.
    Weiss SW. Lipomatous tumors. Monogr Pathol. 1996;38:207–39.PubMedGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Department of PathologyCleveland ClinicClevelandUSA
  2. 2.Department of PathologyUniversity of Michigan Medical SchoolAnn ArborUSA

Personalised recommendations