Malignant Fibrous, Fibrohistiocytic, and Myofibroblastic Tumors

  • Aaron M. Udager
  • Reena Singh
  • Steven D. Billings
  • Rajiv M. PatelEmail author


This chapter covers fibrous, fibrohistiocytic, and myofibroblastic tumors that have metastatic potential. Congenital/infantile fibrosarcoma is the exception to that rule, as it behaves less aggressively than its adult counterpart. Adult-type fibrosarcoma is a diagnosis in decline due to the recognition of distinct variants: low-grade fibromyxoid sarcoma, sclerosing epithelioid fibrosarcoma, myxofibrosarcoma, low-grade myofibroblastic sarcoma (myofibrosarcoma), and myxoinflammatory fibroblastic sarcoma. Undifferentiated pleomorphic sarcoma may also present as a superficial tumor and will be briefly discussed. The chapter closes with a discussion of undifferentiated pleomorphic sarcomas of the skin, specifically atypical fibroxanthoma and pleomorphic dermal sarcoma.


Congenital/infantile fibrosarcoma Adult-type fibrosarcoma Low-grade fibromyxoid sarcoma Sclerosing epithelioid fibrosarcoma Myxofibrosarcoma Low-grade myofibroblastic sarcoma (myofibrosarcoma) Myxoinflammatory fibroblastic sarcoma Undifferentiated pleomorphic sarcoma Atypical fibroxanthoma Pleomorphic dermal sarcoma 

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • Aaron M. Udager
    • 1
  • Reena Singh
    • 2
  • Steven D. Billings
    • 3
  • Rajiv M. Patel
    • 1
    Email author
  1. 1.Department of PathologyUniversity of Michigan Medical SchoolAnn ArborUSA
  2. 2.Department of PathologyOregon Health and Science University School of MedicinePortlandUSA
  3. 3.Department of PathologyCleveland ClinicClevelandUSA

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