Mimics of Cutaneous Mesenchymal Tumors

  • Darya BuehlerEmail author
  • Rajiv M. Patel
  • Steven D. Billings


This chapter briefly describes reactive or neoplastic mimics of primary cutaneous mesenchymal neoplasms that are commonly encountered by dermatopathologists and can lead to misinterpretation as a primary soft tissue tumor, especially sarcoma. A comprehensive review of these lesions is beyond the scope of this chapter; rather, we focus our discussion on helpful histologic clues, diagnostic pitfalls, and useful ancillary tests. The entities reviewed in this chapter and their clinically important mesenchymal tumor mimics are listed in Table 3.1.


Granuloma annulare Rheumatoid nodule Mycobacterial spindle cell pseudotumor Erythema elevatum diutinum Acroangiodermatitis Crystal-storing histiocytosis Silicone granuloma Spindle cell melanoma Desmoplastic melanoma Cellular blue nevus Massive localized lymphedema (MLL) Bizarre parosteal osteochondromatous proliferation (BPOP) Sarcomatoid carcinoma Spindle cell squamous cell carcinoma 

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • Darya Buehler
    • 1
    Email author
  • Rajiv M. Patel
    • 2
  • Steven D. Billings
    • 3
  1. 1.Pathology and Laboratory MedicineUniversity of Wisconsin School of Medicine and Public HealthMadisonUSA
  2. 2.Department of PathologyUniversity of Michigan Medical SchoolAnn ArborUSA
  3. 3.Department of PathologyCleveland ClinicClevelandUSA

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