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Computerized Tomography-Guided Surgical Decision-Making in Primary Squamous Cell Carcinoma of the Oral Cavity

  • Jan-Dirk Raguse
  • Bodo Hoffmeister
  • Rainer SchmelzeisenEmail author
  • Katja Nelson
  • Beat Hamm
  • Nadine Thieme
Chapter
  • 549 Downloads

Abstract

Head and neck cancer is the sixth most common cancer worldwide [1]. One third of it comprises the oral cavity, while squamous cell carcinoma (SCC) represents approximately 95% of the dominating histopathology [2, 3]. In contrast to oropharyngeal squamous cell carcinoma, in which HPV-induced etiology is currently discussed to be associated with a better prognosis, OSCC still remains to be based on tobacco and alcohol as major risk factors [4–6]. Even though great emphasis is placed on early detection and optimized surgical and radio-oncologic techniques, the prognosis remains poor with overall 5-year survival beneath 50%, mainly due to a high rate of locoregional recurrences [1, 2, 7]. Furthermore organ-sparing concepts in terms of induction chemotherapy, currently under investigation in laryngeal malignancies, are not in focus in OSCC [8, 9]. Therefore two main therapeutic strategies remain: [1] upfront surgery followed by adjuvant radiotherapy (RT) or radiochemotherapy (RCT) if necessary, according to histopathologic risk factors, and [2] primary RCT followed by salvage surgery in case of residual disease. The aim of this chapter is to discuss the influence of findings by computed tomography, the worldwide most common imaging modality in head and neck cancer, on therapeutic strategies.

Keywords

Computed tomography Radiographic observation Therapy Surgery Radiotherapy Radiochemotherapy Squamous cell carcinoma Oral cavity tumor Oral cancer HNSSC OSSC SSC CT 

References

  1. 1.
    Simard EP, Torre LA, Jemal A. International trends in head and neck cancer incidence rates: differences by country, sex and anatomic site. Oral Oncol. 2014;50(5):387–403.CrossRefGoogle Scholar
  2. 2.
    Braakhuis BJ, Leemans CR, Visser O. Incidence and survival trends of head and neck squamous cell carcinoma in the Netherlands between 1989 and 2011. Oral Oncol. 2014;50(7):670–5.CrossRefGoogle Scholar
  3. 3.
    Parkin DM, Bray F, Ferlay J, et al. Global cancer statistics, 2002. CA Cancer J Clin. 2005;55(2):74–108.CrossRefGoogle Scholar
  4. 4.
    Sathish N, Wang X, Yuan Y, et al. Human papillomavirus (HPV)-associated oral cancers and treatment strategies. J Dent Res. 2014;24(7 Suppl):29–36.CrossRefGoogle Scholar
  5. 5.
    Fakhry C, D’Souza G. Discussing the diagnosis of HPV-OSCC: common questions and answers. Oral Oncol. 2013;49(9):863–71.CrossRefPubMedPubMedCentralGoogle Scholar
  6. 6.
    Preuss SF, Klussmann JP, Semrau R, et al. Update on HPV-induced oropharyngeal cancer. HNO. 2011;59(10):1031–7.CrossRefGoogle Scholar
  7. 7.
    Omura K. Current status of oral cancer treatment strategies: surgical treatments for oral squamous cell carcinoma. Int J Clin Oncol. 2014;19(3):423–30.CrossRefGoogle Scholar
  8. 8.
    Jenckel F, Knecht R. State of the art in the treatment of laryngeal cancer. Anticancer Res. 2013;33(11):4701–10.PubMedGoogle Scholar
  9. 9.
    Ma J, Liu Y, Huang XL, et al. Induction chemotherapy decreases the rate of distant metastasis in patients with head and neck squamous cell carcinoma but does not improve survival or locoregional control: a meta-analysis. Oral Oncol. 2012;48(11):1076–84.CrossRefGoogle Scholar
  10. 10.
    Dammann F, Horger M, Mueller-Berg M, et al. Rational diagnosis of squamous cell carcinoma of the head and neck region: comparative evaluation of CT, MRI, and 18FDG PET. AJR Am J Roentgenol. 2005;184(4):1326–31.CrossRefGoogle Scholar
  11. 11.
    Ng S-H, Yen T-C, Liao C-T, et al. 18F-FDG PET and CT/MRI in oral cavity squamous cell carcinoma: a prospective study of 124 patients with histologic correlation. J Nucl Med. 2005;46(7):1136–43.PubMedGoogle Scholar
  12. 12.
    Sumi M, Kimura Y, Sumi T, et al. Diagnostic performance of MRI relative to CT for metastatic nodes of head and neck squamous cell carcinomas. J Magn Reson Imaging. 2007;26(6):1626–33.CrossRefGoogle Scholar
  13. 13.
    Wiener E, Pautke C, Link TM, et al. Comparison of 16-slice MSCT and MRI in the assessment of squamous cell carcinoma of the oral cavity. Eur J Radiol. 2006;58(1):113–8.CrossRefGoogle Scholar
  14. 14.
    Andrle J, Schartinger VH, Schwentner I, et al. Initial staging examinations for head and neck squamous cell carcinoma: are they appropriate? J Laryngol Otol. 2009;123(8):885–8.CrossRefGoogle Scholar
  15. 15.
    Ghosh SK, Roland NJ, Kumar A, et al. Detection of synchronous lung tumors in patients presenting with squamous cell carcinoma of the head and neck. Head Neck. 2009;31(12):1563–70.CrossRefGoogle Scholar
  16. 16.
    Loh KS, Brown DH, Baker JT, et al. A rational approach to pulmonary screening in newly diagnosed head and neck cancer. Head Neck. 2005;27(11):990–4.CrossRefGoogle Scholar
  17. 17.
    Genden EM, Ferlito A, Silver CE, et al. Contemporary management of cancer of the oral cavity. Eur Arch Otorhinolaryngol. 2010;267(7):1001–17.CrossRefPubMedPubMedCentralGoogle Scholar
  18. 18.
    Machiels JP, Lambrecht M, Hanin FX, et al. Advances in the management of squamous cell carcinoma of the head and neck. F1000Prime Rep. 2014;6:44.Google Scholar
  19. 19.
    Grégoire V, Ang K, Budach W, et al. Delineation of the neck node levels for head and neck tumors: a 2013 update. DAHANCA, EORTC, HKNPCSG, NCIC CTG, NCRI, RTOG, TROG consensus guidelines. Radiother Oncol. 2014;110(1):172–81.CrossRefGoogle Scholar
  20. 20.
    Cooper JS, Zhang Q, Pajak TF, et al. Long-term follow-up of the RTOG 9501/intergroup phase III trial: postoperative concurrent radiation therapy and chemotherapy in high-risk squamous cell carcinoma of the head and neck. J Radiat Oncol Biol Phys. 2012;84(5):1198–205.CrossRefGoogle Scholar
  21. 21.
    Bernier J, Cooper JS, Pajak TF, et al. Defining risk levels in locally advanced head and neck cancers: a comparative analysis of concurrent postoperative radiation plus chemotherapy trials of the EORTC (#22931) and RTOG (# 9501). Head Neck. 2005;27(10):843–50.CrossRefGoogle Scholar
  22. 22.
    Edge SB, Compton CC. The American Joint Committee on Cancer: the 7th edition of the AJCC Cancer Staging Manual and the Future of TNM. Ann Surg Oncol. 2010;17(6):1471–4.Google Scholar
  23. 23.
    Marx RE. A new concept in the treatment of osteoradionecrosis. J Oral Maxillofac Surg. 1983;41(6):351–7.CrossRefGoogle Scholar
  24. 24.
    Studer G, Studer SP, Zwahlen RA, et al. Osteoradionecrosis of the mandible: minimized risk profile following intensity-modulated radiation therapy (IMRT). Strahlenther Onkol. 2006;182:283–8.CrossRefGoogle Scholar
  25. 25.
    Thorn JJ, Hansen HS, Specht L, et al. Osteoradionecrosis of the jaws: clinical characteristics and relation to the field of irradiation. J Oral Maxillofac Surg. 2000;58(10):1088–93.CrossRefGoogle Scholar
  26. 26.
    Arya S, Rane P, Deshmukh A. Oral cavity squamous cell carcinoma: role of pretreatment imaging and its influence on management. Clin Radiol. 2014;69(9):916–30.Google Scholar
  27. 27.
    Omura K. Current status of oral cancer treatment strategies: surgical treatments for oral squamous cell carcinoma. Int J Clin Oncol. 2014;19(3):423–30.Google Scholar
  28. 28.
    Troeltzsch M, Knösel T, Eichinger C, et al. Clinicopathologic features of oral squamous cell carcinoma: do they vary in different age groups? J Oral Maxillofac Surg. 2014;72(7):1291–300.Google Scholar
  29. 29.
    Million RR, Cassisi NJ, Mancuso AA. Oral cavity. In: Million RR, Cassisi NJ, editors. Management of Head and Neck Cancer: a Multidisciplinary Approach. 2nd ed. Philadelphia: Lippincott; 1994. p. 321–400.Google Scholar
  30. 30.
    Siriwardena BS, Tilakaratne A, Amaratunga EA, et al. Demographic, aetiological and survival differences of oral squamous cell carcinoma in the young and the old in Sri Lanka. Oral Oncol. 2006;42(8):831–6.CrossRefGoogle Scholar
  31. 31.
    Bolzoni A, Cappiello J, Piazza C, et al. Diagnostic accuracy of magnetic resonance imaging in the assessment of mandibular involvement inoral-oropharyngeal squamous cell carcinoma: a prospective study. Arch Otolaryngol Head Neck Surg. 2004;130(7):837–43.CrossRefGoogle Scholar
  32. 32.
    Imaizumi A, Yoshino N, Yamada I, et al. A potential pitfall of MR imaging for assessing mandibular invasion of squamous cell carcinoma in the oral cavity. AJNR Am J Neuroradiol. 2006;27(1):114–22.PubMedGoogle Scholar
  33. 33.
    Dreiseidler T, Alarabi N, Ritter L, et al. A comparison of multislice computerized tomography, cone-beam computerized tomography, and single photon emission computerized tomography for the assessment of bone invasion by oral malignancies. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2011;112(3):367–74.CrossRefGoogle Scholar
  34. 34.
    Kontio R. Update on mandibular reconstruction: computer-aided design, imaging, stem cells and future applications. Curr Opin Otolaryngol Head Neck Surg. 2014;22(4):307–15.CrossRefGoogle Scholar
  35. 35.
    van Vlijmen OJ, Bergé SJ, Swennen GR, et al. Comparison of cephalometric radiographs obtained from cone-beam computed tomography scans and conventional radiographs. J Oral Maxillofac Surg. 2009;67(1):92–7.CrossRefGoogle Scholar
  36. 36.
    Hendrikx AW, Maal T, Dieleman F, et al. Cone-beam CT in the assessment of mandibular invasion by oral squamous cell carcinoma: results of the preliminary study. Int J Oral Maxillofac Surg. 2010;39(5):436–9.CrossRefGoogle Scholar
  37. 37.
    Kato H, Kanematsu M, Makita H, et al. CT and MR imaging findings of palatal tumors. Eur J Radiol. 2014;83(3):e137–46.CrossRefGoogle Scholar
  38. 38.
    Trotta BM, Pease CS, Rasamny JJ, et al. Oral cavity and oropharyngeal squamous cell cancer: key imaging findings for staging and treatment planning. Radiographics. 2011;31(2):339–54.CrossRefGoogle Scholar
  39. 39.
    Gandhi D, Gujar S, Mukherji SK. Magnetic resonance imaging of perineural spread of head and neck malignancies. Top Magn Reson Imaging. 2004;15(2):79–85.CrossRefGoogle Scholar
  40. 40.
    Cohan DM, Popat S, Kaplan SE, et al. Oropharyngeal cancer: current understanding and management. Curr Opin Otolaryngol Head Neck Surg. 2009;17(2):88–94.CrossRefGoogle Scholar
  41. 41.
    Liao CT, Ng SH, Chang JT, et al. T4b oral cavity cancer below the mandibular notch is resectable with a favorable outcome. Oral Oncol. 2007;43(6):570–9.CrossRefGoogle Scholar
  42. 42.
    Liao CT, Chang JT, Wang HM, et al. Surgical outcome of T4a and resected T4b oral cavity cancer. Cancer. 2006;107(2):337–44.CrossRefGoogle Scholar
  43. 43.
    de Juan J, García J, López M, et al. Inclusion of extracapsular spread in the pTNM classification system: a proposal for patients with head and neck carcinoma. JAMA Otolaryngol Head Neck Surg. 2013;139(5):483–8.CrossRefGoogle Scholar
  44. 44.
    Cojocariu OM, Huguet F, Lefevre M, et al. Prognosis and predictive factors in head-and-neck cancers. Bull Cancer. 2009;96(4):369–78.CrossRefGoogle Scholar
  45. 45.
    Matos LL, Manfro G, Santos RV, et al. Tumor thickness as a predictive factor of lymph node metastasis and disease recurrence in T1N0 and T2N0 squamous cell carcinoma of the oral tongue. Oral Surg Oral Med Oral Pathol Oral Radiol. 2014;118(2):209–17.Google Scholar
  46. 46.
    Dias FL, Lima RA, Kligerman J, et al. Relevance of skip metastases for squamous cell carcinoma of the oral tongue and the floor of the mouth. Otolaryngol Head Neck Surg. 2006;134(3):460–5.CrossRefGoogle Scholar
  47. 47.
    Chai RL, Rath TJ, Johnson JT, et al. Accuracy of computed tomography in the prediction of extracapsular spread of lymph node metastases in squamous cell carcinoma of the head and neck. JAMA Otolaryngol Head Neck Surg. 2013;139(11):1187–94.CrossRefGoogle Scholar
  48. 48.
    Yoo GH, Hocwald E, Korkmaz H, et al. Assessment of carotid artery invasion in patients with head and neck cancer. Laryngoscope. 2000;110(3Pt 1):386–90.CrossRefGoogle Scholar
  49. 49.
    Rohde M, Dyrvig AK, Johansen J, et al. 18F-fluoro-deoxy-glucose-positron emission tomography/computed tomography in diagnosis of head and neck squamous cell carcinoma: a systematic review and meta-analysis. Eur J Cancer. 2014;50(13):2271–9.CrossRefGoogle Scholar
  50. 50.
    Heusch P, Sproll C, Buchbender C, et al. Diagnostic accuracy of ultrasound, 18F-FDG-PET/CT, and fused 18F-FDG-PET-MR images with DWI for the detection of cervical lymph node metastases of HNSCC. Clin Oral Investig. 2014;18(3):969–78.CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • Jan-Dirk Raguse
    • 1
  • Bodo Hoffmeister
    • 2
  • Rainer Schmelzeisen
    • 3
    Email author
  • Katja Nelson
    • 4
  • Beat Hamm
    • 5
  • Nadine Thieme
    • 5
  1. 1.Clinic for Oral- and Maxillofacial Surgery, Navigation and Robotics, Charité Campus Virchow, Charité Universitätsmedizin BerlinBerlinGermany
  2. 2.Oral and Maxillofacial Surgery, Private PracticeZürichSwitzerland
  3. 3.Department of Oral and Maxillofacial Surgery/Regional Plastic SurgeryCenter for Dental Medicine, Medical Center - University of Freiburg, Faculty of Medicine, University of FreiburgFreiburgGermany
  4. 4.Department of Oral and Maxillofacial Surgery/Translational ImplantologyCenter for Dental Medicine, Medical Center - University of Freiburg, Faculty of Medicine, University of FreiburgFreiburgGermany
  5. 5.Institute for Radiology Charité Campus Virchow/Charité Campus Mitte, Charité Universitätsmedizin BerlinBerlinGermany

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