• Robert C. Petersen
Part of the Readings from the Encyclopedia of Neuroscience book series (REN)


Phencyclidine, or PCP, chemically one of the arylcyclohexylamines, was originally developed as a dissociative anesthetic in the late 1950s. It was abandoned (for humans, but not other primates) in the mid 1960s because patients so often showed marked confusion and irrational behavior mimicking schizophrenia during postoperative recovery. Although PCP is the best known of about 30 psychoactive analogs, others, including PCE, TCP, PHP, PCC, and the shorter acting anesthetic, ketamine, are chemically related and have similar psychophysiological effects.

Further reading

  1. Chasnoff IJ, Burns WJ, Hatcher RP, Burns KA (1983): Phencyclidine: Effects on the fetus and neonate. Dev Pharmacol Ther 6(6): 404–408Google Scholar
  2. Clouet DH (1986): Phencyclidine: An Update, NIDA Reasearch Monograph, DHHS Publ No (ADM) 86–1443, Washington, D.C.: US Government Printing OfficeGoogle Scholar
  3. Khansari N, Whitten HD, Fudenberg HH (1984): Phencylidineinduced immunodepression. Science 225(4657): 76–78CrossRefGoogle Scholar
  4. Petersen RC, Stillman RC, eds (1978): Phencyclidine (PCP) Abuse; An Appraisal, NIDA Research Monograph, DHEW Publ No (ADM) 78–728. Washington DC: US Government Printing OfficeGoogle Scholar
  5. Walberg CB, McCarron MM, Schulze BN (1983): Quantitation of phencyclidine in serum by enzyme immunoassay: Results in 405 patients. J Anal Tox 7(2): 106–110CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1989

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  • Robert C. Petersen

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