Phencyclidine, or PCP, chemically one of the arylcyclohexylamines, was originally developed as a dissociative anesthetic in the late 1950s. It was abandoned (for humans, but not other primates) in the mid 1960s because patients so often showed marked confusion and irrational behavior mimicking schizophrenia during postoperative recovery. Although PCP is the best known of about 30 psychoactive analogs, others, including PCE, TCP, PHP, PCC, and the shorter acting anesthetic, ketamine, are chemically related and have similar psychophysiological effects.
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