Lithium in Psychiatric Therapy

  • James W. Jefferson
  • John H. Greist
Part of the Readings from the Encyclopedia of Neuroscience book series (REN)


While lithium was used in 19th and early 20th century medicine, its ascent to current prominence began in the late 1940s when John Cade, an Australian psychiatrist, noted its antimanic effect. Subsequently, Mogens Schou and colleagues, in Denmark, established that long-term lithium therapy reduced both frequency and severity of episodes in patients with manicdepressive disorder (bipolar affective disorder). These observations were, in part, responsible for a renewed interest in psychiatric diagnosis since distinguishing manic-depressive disorder from the schizophrenias now had important therapeutic implications.

Further reading

  1. Jefferson JW, Greist JH, Ackerman DL (1983): Lithium Encyclopedia for Clinical Practice. Washington: American Psychiatric PressGoogle Scholar
  2. Johnson FN, ed (1980): Handbook of Lithium Therapy. Lancaster, England: MTP PressGoogle Scholar
  3. Lazarus JH (1982): Endocrine and metabolic effects of lithium. Adv Drug React Ac Pois Rev 1: 181–200Google Scholar
  4. Knapp S (1983): Lithium. In: Psychopharmacology J, Part 1: Preclinical Psychopharmacology, Grahme-Smith DG, Cowen PJ, eds. Amsterdam: Excerpta MedicaGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1989

Authors and Affiliations

  • James W. Jefferson
  • John H. Greist

There are no affiliations available

Personalised recommendations