Lithium in Psychiatric Therapy
While lithium was used in 19th and early 20th century medicine, its ascent to current prominence began in the late 1940s when John Cade, an Australian psychiatrist, noted its antimanic effect. Subsequently, Mogens Schou and colleagues, in Denmark, established that long-term lithium therapy reduced both frequency and severity of episodes in patients with manicdepressive disorder (bipolar affective disorder). These observations were, in part, responsible for a renewed interest in psychiatric diagnosis since distinguishing manic-depressive disorder from the schizophrenias now had important therapeutic implications.
- Jefferson JW, Greist JH, Ackerman DL (1983): Lithium Encyclopedia for Clinical Practice. Washington: American Psychiatric PressGoogle Scholar
- Johnson FN, ed (1980): Handbook of Lithium Therapy. Lancaster, England: MTP PressGoogle Scholar
- Lazarus JH (1982): Endocrine and metabolic effects of lithium. Adv Drug React Ac Pois Rev 1: 181–200Google Scholar
- Knapp S (1983): Lithium. In: Psychopharmacology J, Part 1: Preclinical Psychopharmacology, Grahme-Smith DG, Cowen PJ, eds. Amsterdam: Excerpta MedicaGoogle Scholar