Creutzfeldt-Jakob Disease

  • Clarence J. GibbsJr.
  • David M. Asher
Part of the Readings from the Encyclopedia of Neuroscience book series (REN)


Creutzfeldt-Jakob disease (CJD), together with its clinical variants, is the more common of the two subacute human spongiform encephalopathies, the other being kuru. The spongiform encephalopathies are slow infections caused by filterable self-replicating agents, the nature of which is not yet fully elucidated. The human diseases resemble three conditions of animals: scrapie of sheep and goats, transmissible mink encephalopathy, and wasting disease of mule deer and elk.


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Further reading

  1. Gajdusek DC (1977): Unconventional viruses and the origin and disappearance of kuru. Science 197: 943–960CrossRefGoogle Scholar
  2. Gajdusek DC (1985): Unconventional viruses causing subacute spongiform encephalopathies. pp 1519–1557. In: “Virology” BN Fields, ed. New York: Raven PressGoogle Scholar
  3. Merz PA, et al (1984): Infection-specific particle from the unconventional virus diseases. Science 225: 437–440CrossRefGoogle Scholar
  4. Oesch B, et al (1985): A cellular gene encodes scrapie PrP27–30 protein. Cell 40: 735–746CrossRefGoogle Scholar
  5. Prusiner SB (1982): Novel proteinaceous particles cause scrapie. Science 216: 136–144CrossRefGoogle Scholar
  6. Rohwer RG (1984): Scrapie infectious agent is virus-like in size and susceptibility to inactivation. Nature (London) 308: 658–662CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1989

Authors and Affiliations

  • Clarence J. GibbsJr.
  • David M. Asher

There are no affiliations available

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