Nuclear Magnetic Resonance and Optical Studies of Polypeptide Chain Conformation
If our main interest is in polypeptides of a single repeating residue, then only a relatively limited number of molecular parameters may be adequate for a good description.
X-ray studies are limited for the most part to crystalline solids and, except in certain special circumstances, cannot inform us what bio-polymers are doing in solution. (One such exception is the x-ray study of polypeptides in solution by Brady, Salovey and Reddy1 in our laboratories; this requires labelling with heavy atoms such as bromine.)
Optical and n.m.r. methods have an intrinsic interest in their own right. This may be the most important reason for using them.
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- 7.D. I. Marlborough, K. G. Orrell, and H. N. Rydon. Chem. Comm. 518 (1965).Google Scholar