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Squash: A Procedure for Phase Refinement and Extension of Protein Structures

  • Kevin Cowtan
Chapter
Part of the NATO ASI Series book series (NSSB, volume 274)

Abstract

Direct methods are now well established as an automatic method for the solution of small molecule structures. Features expected of the electron density are used to constrain the values of the unknown phases. The result is a map at atomic resolution from which atomic co-ordinates can be extracted by peak search routines.

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References

  1. Main, P., 1990, The Use of Sayre’s Equation with Constraints for Direct Determination of Phases, Acta Cryst. (to be published)Google Scholar
  2. Sayre, D., 1952, Acta Cryst, 5:60CrossRefGoogle Scholar
  3. Wang, B.C., 1985, Methods in Enzymology 115:90Google Scholar
  4. Zhang, K.Y.J., 1989, “On the Phase Refinement and Extension of Macromolecular Structures using both Real and Reciprocal Space Approaches.” (Thesis), University of YorkGoogle Scholar
  5. Zhang, K.Y.J., Main, P., 1990, Histogram Matching as a New Density Modification Technique for Phase Refinement and Extension of Protein Molecules, Acta Cryst. A46:41CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1991

Authors and Affiliations

  • Kevin Cowtan
    • 1
  1. 1.Department of PhysicsUniversity of YorkHeslington, YorkEngland

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