Direct Methods for Macromolecular Crystallography

  • Suzanne Fortier
Part of the NATO ASI Series book series (NSSB, volume 274)


The term “direct methods”, as it is used in a small molecule context, refers to crystal structure determination methods that take advantage of relationships among the structure factors to extract missing phase information from the observed intensities. An initial model of the structure can thus be calculated with little or no a priori chemical information. While in general the chemical content of the unit cell is known, even this information is not essential for the successful application of direct methods. Indeed there are numerous examples of crystal structures solved with unknown or presumably known, but erroneous, chemical formulae.


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Copyright information

© Springer Science+Business Media New York 1991

Authors and Affiliations

  • Suzanne Fortier
    • 1
  1. 1.Department of ChemistryQueen’s UniversityKingstonCanada

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