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Coronavirus Receptors

  • Kathryn V. Holmes
  • Susan R. Compton
Chapter
Part of the The Viruses book series (VIRS)

Abstract

Coronaviruses are highly species-specific in that they generally cause disease in only one host species (Möstl, 1990; Wege et al., 1982). However, experimental inoculation of other species with several coronaviruses, either by artificial routes such as intracerebral inoculation or in the highly susceptible neonatal period, can result in mild or asymptomatic infection as shown in Table I. In general, coronaviruses only infect cells from their normal host species or from species that are susceptible to infection with an antigenically related coronavirus (Table II). Host-dependent differences in susceptibility to coronavirus infection can be demonstrated within a species. For example, different strains of inbred mice vary greatly in their susceptibility to infection with various murine hepatitis virus (MHV) strains (Bang and Warwick, I960; Stohlman et al., 1980; Wege et al., 1982).

Keywords

Tissue Tropism Mouse Hepatitis Virus Intestinal Brush Border Membrane Transmissible Gastroenteritis Virus Spike Glycoprotein 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1995

Authors and Affiliations

  • Kathryn V. Holmes
    • 1
  • Susan R. Compton
    • 2
  1. 1.Department of PathologyUniformed Services University of the Health SciencesBethesdaUSA
  2. 2.Section of Comparative MedicineYale UniversityNew HavenConnecticutUSA

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