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Pathogenesis and Diseases of the Central Nervous System Caused by Murine Coronaviruses

  • Samuel Dales
  • Robert Anderson
Chapter
Part of the The Viruses book series (VIRS)

Abstract

This chapter is an account of studies of central nervous system (CNS) diseases connected with neurotropic variants of MCV such as J. Howard Müller Virus (JHM) and A59 and deals with animal models that may have relevance to an understanding of human diseases of putative viral etiology such as multiple sclerosis (MS). From the time of (JHMV) isolation from paralyzed mice by Cheever et al. (1949) and Bailey et al. (1949), this agent and related strains have provided copious data about encephalitic and demyelinating diseases in rodents. To date, however, any possible connection between murine Coronavirus (MCV) and MS is tenuous. The reported isolation of Coronavirus (CV) particles from MS patients’ brain (Burks et ah, 1980) or electron microscopic visualization of CV-like particles in brain tissue of one MS patient (Tanaka et al., 1976), require confirmation. An older report of JHMV-induced panencephalitis in monkeys (Kersting and Pette, 1956), however, has been confirmed by Murray et al. (1992a) in their description of demyelinative disease in several monkey species. This finding, coupled with the identification of viral RNA and protein within demyelinative plaques in human brain tissue from MS patients (Murray et al., 1992b; Stewart et al., 1992), are highly provocative data concerning an involvement of CV in the etiology of MS. However, a cautious evaluation of these results may be in order, in view of the recent demonstration of genomic and antigenic relatedness between the N protein of JHMV and the microtubule-associated protein tau (Pasick et al., 1994).

Keywords

Measle Virus Demyelinating Disease Canine Distemper Virus Mouse Hepatitis Virus Human Coronavirus 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1995

Authors and Affiliations

  • Samuel Dales
    • 1
  • Robert Anderson
    • 2
  1. 1.Cytobiology Group, Department of Microbiology and ImmunologyThe University of Western OntarioLondonCanada
  2. 2.Department of Microbiology and ImmunologyDalhousie UniversityHalifaxCanada

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