The Coronaviridae

An Introduction
  • Stuart G. Siddell
Part of the The Viruses book series (VIRS)


The Coronaviridae are a group of enveloped, positive-strand RNA viruses with nonsegmented genomes of about 30,000 nucleotides. The family comprises two genera, coronavirus and torovirus, which share similarities in the organization and expression of their genomes and the structure of the viral gene products. Viruses in the two genera have, however, only limited sequence similarity and display; for example, distinctly different nucleocapsid morphologies.


Infectious Bronchitis Virus Nucleocapsid Protein Feline Infectious Peritonitis Transmissible Gastroenteritis Virus Feline Infectious Peritonitis Virus 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


  1. Beards, G. M., Hall, C., Green, J., Flewett, T. H., Lamouliatte, F., and Du Pasquier, P., 1984, An enveloped virus in stools of children and adults with gastroenteritis that resembles the Breda virus of calves, Lancet 2:1050.CrossRefGoogle Scholar
  2. Beards, G. M., Brown, D. W. G., Green, J., and Flewett, T. H., 1986, Preliminary characterisation of torovirus-like particles of humans: Comparison with Berne virus of horses and Breda viruses of calves, J. Med. Virol 20:67.PubMedCrossRefGoogle Scholar
  3. Cavanagh, D., Brian, D. A., Enjuanes, L., Holmes, K. V., Lai, M. M. C., Laude, H., Siddell, S. G., Spaan, W. J. M., Taguchi, F., and Talbot, P. J., 1990, Recommendations of the coronavirus study group for the nomenclature of the structural proteins, mRNAs and genes of coronaviruses, Virology 176:306.PubMedCrossRefGoogle Scholar
  4. Cavanagh, D., Brian, D. A., Brinton, M. A., Enjuanes, L., Holmes, K. V., Horzinek, M. C., Lai, M. M. C., Laude, H., Plagemann, P. W., Siddell, S. G., Spaan, W. J. M., Taguchi, F., and Talbot, P. J., 1995, Coronaviridae, in: Virus Taxonomy, The Classification and Nomenclature of Viruses. Sixth Report of the ICTV (D. H. L. Bishop et al., eds.), Springer-Verlag, Wien, New York.Google Scholar
  5. Dea, S., Verbeek, A. J., and Tijssen, P., 1990, Antigenic and genomic relationships among turkey and bovine enteric coronaviruses, J. Virol. 64:3112.PubMedGoogle Scholar
  6. Higgins, D. G., and Sharp, P. M., 1989, Fast and sensitive multiple sequence alignments on a microcomputer, CABIOS 5:151.PubMedGoogle Scholar
  7. Saitou, N., and Nei, M., 1987, A new method for reconstructing phylogenetic trees, Mol. Biol. Evol. 4:406.PubMedGoogle Scholar
  8. Sanchez, C. M., Jiminez, G., Laviada, M. D., Correa, I., Sune, C., Bullido, M. J., Gebauer, F., Smerdou, C., Callebaut, P., Escribano, J. M., and Enjuanes, L., 1990, Antigenic homology among coronaviruses related to transmissible gastroenteritis virus, Virology 174:410.PubMedCrossRefGoogle Scholar
  9. Snijder, E., and Horzinek, M. C., 1993, Toroviruses: Replication, evolution and comparison with other members of the coronavirus-like superfamily, J. Gen. Virol. 74:2305.PubMedCrossRefGoogle Scholar
  10. Spaan, W., Cavanagh, D., and Horzinek, M. C., 1988, Coronaviruses: Structure and genome expression, J. Gen. Virol. 69:2939.PubMedCrossRefGoogle Scholar
  11. Spaan, W. J. M., Cavanagh, D., and Horzinek, M. C., 1990, Coronaviruses, in: Immunochemistry of Viruses, Vol. 2, The Basis for Serodiagnosis and Vaccines (M. H. V. Regenmortel and A. R. Neurath, eds.), pp. 359–379, Elsevier, Amsterdam.Google Scholar
  12. Weiss, M., and Horzinek, M. C., 1987, The proposed family Toroviridae: Agents of enteric infections, Arch. Virol. 92:1.PubMedCrossRefGoogle Scholar
  13. Yokomori, K., Banner, L. R., and Lai, M. M. C., 1991, Heterogeneity of gene expression of the haemagglutinin-esterase (HE) protein of murine coronaviruses, Virology 183:647.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1995

Authors and Affiliations

  • Stuart G. Siddell
    • 1
  1. 1.Institute of Virology and ImmunobiologyUniversity of WürzburgWürzburgGermany

Personalised recommendations